Safety and Pharmacokinetics of Glecaprevir/Pibrentasvir in Adults With Chronic Genotype 1–6 Hepatitis C Virus Infections and Compensated Liver Disease만성 유전자형 1-6형 C형 간염 바이러스 감염 및 대상성 간 질환이 있는 성인에서 Glecaprevir/Pibrentasvir의 안전성 및 약동학Major Articles and Commentaries Published on 2019-11-152022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] adverse event Analysis Antiviral Child-Pugh A chronic chronic hepatitis Chronic kidney disease cirrhosis CKD class clinical clinical trials clinically Combination compensated compensated cirrhosis demonstrated direct-acting Drug-induced liver injury Efficacy Efficacy and safety evaluate fatigue Frequency Genotype glecaprevir glecaprevir/pibrentasvir HCV headache hepatitis C hepatitis C virus increase in Infection Kidney disease lead liver Liver Biopsy Liver damage Liver disease Liver injury Patient patients pharmacokinetics phase pibrentasvir PK analysis regimen Registration Result ribavirin SAE SAEs Safe Safety serious AE serum biomarkers Stage sustained Treatment was determined [DOI] 10.1093/cid/ciz022 PMC 바로가기 [Article Type] Major Articles and Commentaries
Chronic hepatitis B: The interplay between intrahepatic lymphocyte population and viral antigens in relation to liver damageArticle Published on 2019-06-012023-06-19 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Chronic Hepatitis B inflammatory infiltrate Liver damage Viral antigen [DOI] 10.1111/jvh.13078
Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector FunctionImmunology Published on 2019-04-102022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] ameliorated caused CD11b Cell cytokine cytotoxicity deficiency degranulation development domain effector evidenced exhibited expressed expression fulminant hepatitis function granzyme B Hepatitis hepatitis B homologous identify IFN-γ Immune-mediated in vitro Infection investigated Kctd9 knockout mice Lineage liver Liver damage manifested maturation mechanism mice murine hepatitis virus natural natural killer NK cell NK cell function NK cells Patient phenotype potassium channel progression proliferative proportion reduction in Regulation selective supported survival transcription factors tumor cell wild-type [DOI] 10.3389/fimmu.2019.00744 PMC 바로가기 [Article Type] Immunology
Depletion of RIPK1 in hepatocytes exacerbates liver damage in fulminant viral hepatitisArticle Published on 2019-01-082022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, [키워드] administration Affect anti-viral response Apoptosis death demonstrated Depletion described double-stranded RNA early stage exacerbate fulminant viral hepatitis Genotype HBV HBV infection Hepatitis Hepatitis B virus hepatocyte homozygous infected patients labeling Liver damage liver parenchymal cell liver tissue Macrophage mice mimicking murine murine hepatitis virus Mutation pathogen-associated molecular polymorphism Prevent primary culture PROTECT Protein RIPK1 risk secreted severe symptom signaling pathway stimulated syndrome TNF-α to define transaminase triggered wild-type worsening [DOI] 10.1038/s41419-018-1277-3 PMC 바로가기 [Article Type] Article
Clara Cell 10 kDa Protein Alleviates Murine Hepatitis Virus Strain 3-Induced Fulminant Hepatitis by Inhibiting Fibrinogen-Like Protein 2 ExpressionImmunology Published on 2018-12-132022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] abrogated accompanied administration allergic rhinitis ALT anti-inflammatory property Apoptosis AST Asthma CC10 Cell cells co-immunoprecipitation control group determine disease downregulated Effect examined expression Fgl2 fulminant fulminant hepatitis HBP1 Hepatitis histology Human IL-1β Immune cell in vitro Infection inhibit inhibitory effect injection innate immune responses Interaction investigated involved kDa Kupffer cells liver Liver damage Liver function Macrophage macrophages mechanism MHV-3 mice murine hepatitis virus Necrosis pathogenic peritoneal macrophage PROTECT Protein Real-time PCR Regulation Regulatory represse serum shown significantly strain suggested survival rate THP-1 TNF-α transcription factor Treatment Vein viral infection was reduced western blot [DOI] 10.3389/fimmu.2018.02935 PMC 바로가기 [Article Type] Immunology
Effects of Virologic Response to Treatment on Short- and Long-term Outcomes of Patients With Chronic Hepatitis B Virus Infection and Decompensated CirrhosisObservational Study Published on 2018-12-012023-06-18 Journal: Clinical gastroenterology and hepatology : the off [Category] B형 간염, [키워드] drug Liver damage Prognostic factor Viral Hepatitis Outcome. [DOI] 10.1016/j.cgh.2018.04.063 [Article Type] Observational Study
Adefovir dipivoxil loaded proliposomal powders with improved hepatoprotective activity: formulation, optimization, pharmacokinetic, and biodistribution studiesArticle Published on 2018-12-012023-06-18 Journal: Journal of liposome research [Category] B형 간염, [키워드] adefovir dipivoxil biodistribution studies Liver damage proliposomes thioacetamide. [DOI] 10.1080/08982104.2017.1363228
Discrepant Clinical Significance of CD28+CD8- and CD4+CD25high Regulatory T Cells During the Progression of Hepatitis B Virus InfectionArticle Published on 2018-10-012023-06-18 Journal: Viral immunology [Category] B형 간염, [키워드] CD28+CD8− regulatory T cells CD4+CD25high regulatory T cells Hepatitis B virus infection Liver damage [DOI] 10.1089/vim.2018.0035
Therapeutic implications of granulocyte colony stimulating factor in patients with acute-on-chronic liver failure: increased survival and containment of liver damageRandomized Controlled Trial Published on 2017-11-012023-06-18 Journal: Hepatology international [Category] B형 간염, [키워드] Acute-on-chronic liver failure Granulocyte colony stimulating factor (G-CSF) Liver damage [DOI] 10.1007/s12072-017-9814-1 [Article Type] Randomized Controlled Trial
Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) InfectionResearch Article Published on 2011-07-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activate anti-IFN-γ anti-TNF-α Author blockade cascades CD4 CD8 cells characteristic co-expressed Coagulation Combination Control damaged demonstrated described determined exhibited expression Fgl2 FH fibrinogen Fluorescence fulminant viral hepatitis functional hepatocellular IFN-γ immunopathological immunopathological damage Immunotherapy in vivo Infection inhibitory receptor initiate injection investigated led to limit liver Liver damage Lymph node lymph nodes mAb Macrophage maintain mechanism mice Mortality mortality rate mRNA multiple organs murine hepatitis virus Necrosis NK cell occurred organ Pathogenesis peripheral tolerance produced promote Protein Quantitative reduced related RT-PCR sensitive Signaling significantly higher spleen T cells tissue tissue damage tissue lesion tissue lesions TNF-α Transcription was determined wild type wild-type [DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article