Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure DeterminationSARS-CoV-2 주요 프로테아제 억제제로서의 소분자 티오에스테르: 효소 억제, 구조-활성 관계, 항바이러스 활성 및 X선 구조 결정Article Published on 2022-07-142022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro activity antiviral activity beta-coronaviruses Calu Calu-3 catalytic cells Compound Coronaviral coronavirus covalent binding crystallization Cys145 Determination exhibited host cell in viral infections inhibited inhibition inhibitor inhibitors M pro MERS-CoV protease Replication residue SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 Mpro Structure synthesis thioester Toxicity Transcription treat viral replication X-ray [DOI] 10.1021/acs.jmedchem.2c00636 PMC 바로가기 [Article Type] Article
Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants신규 설계된 SARS-CoV-2 HR1 삼량체, SARS-CoV-2 및 그 변이체에 대해 향상된 효능 및 광범위한 활성을 나타냄Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activities activity adopted affinity antibodies binding affinity C terminus caused cell-cell fusion develop domain effective Effectiveness foldon foundation fusing fusion fusion inhibitor global public health HR1 HR1 domain Improved increased the risk information inhibit inhibit SARS-CoV-2 inhibitor inhibitors inhibitory inhibitory activity limit MERS MERS-CoV MERS-CoV pseudoviruses motif much higher Multiple NAbs Neutralizing antibodies neutralizing antibody novel pandemic of COVID-19 peptide Peptide inhibitor Peptide Inhibitors peptides potency provide pseudoviruses reported S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Spread the S protein the SARS-CoV-2 theory treating SARS-CoV-2 infection trimer trimeric Vaccine variants viral infection viral S protein viral variant Viral variants VOCs [DOI] 10.1128/jvi.00681-22 PMC 바로가기 [Article Type] Article
Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle VaccinesS1 나노입자 백신에 의한 SARS-CoV-2 변이체에 대한 광범위한 교차 반응성 항체 반응의 유도Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody titers betacoronaviruses Characteristics comparable coronavirus COVID-19 cross-protective immunity cross-reactive cross-reactivity effective elicit elicited exhibited homogeneity humoral immune evasion Immunity induction Infection MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus monomer nanoparticle nanoparticle vaccine Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers novel vaccines omicron pathogenic respiratory respiratory syndrome coronavirus response S1 SARS-CoV SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Spike protein spike protein S1 stability Vaccine vaccine candidate vaccine candidates Vaccines variant variants variants of concern variants of interest wild-type wild-type SARS-CoV-2 [DOI] 10.1128/jvi.00383-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent originSARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis approaches assays Autoimmune disease Autoimmune diseases Betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology [DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article
Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19COVID-19에 대한 작용 기전으로서 SARS-CoV-2 N 단백질의 비천연 단백질-단백질 상호작용의 소분자 안정화Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료법, [키워드] absence addition Affect analyzed applicability catechin caused Compound coronavirus COVID-19 docking drug design Drug discovery effective exploration identify inhibit mechanism mechanism of action MERS MERS-CoV molecular molecular dynamics NTD nucleocapsid protein outbreak protein-protein interaction protocol reported Research residue responsible SARS-CoV-2 SARS-CoV-2 N protein small molecule the disease Treatment viral replication Virtual screening [DOI] 10.1080/07391102.2020.1860828 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used [DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article
The COVID-19 pandemic – How many times were we warned before?Review article Published on 2022-07-012022-10-05 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome caused consequence coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 pandemic disease Diseases emerging disease Epidemics evaluate indicated MERS MERS-CoV Middle East outbreak Outbreaks pandemic of COVID-19 Pandemics pathogen predicted researcher respiratory syndrome coronavirus SARS SARS-CoV SARS-CoV-2 Taking the WHO while WHO World Health Organization [DOI] 10.1016/j.ejim.2022.07.009 [Article Type] Review article
CROMATIC: Cro ss-Relationship Ma p of Cavi ti es from C oronavirusesCHROMATIC: 코로나바이러스의 Cavi 시간 교차 관계 지도Article Published on 2022-06-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alterations Analysis conserved coronavirus COVID-19 disease database drug candidates effective etiologic agent help high resolution highlighting identify Interaction MERS MERS-CoV molecular interaction Mutation performed Protein protocols Repository SARS-CoV SARS-CoV-2 SARS-CoV-2 spike variants Scientific community sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity starting point Structure structures therapy Virtual screening X-ray [DOI] 10.1021/acs.jcim.2c00169 PMC 바로가기 [Article Type] Article
Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease중증 급성 호흡기 증후군 코로나바이러스-2 3C 유사 프로테아제의 강력한 스피로사이클릭 억제제의 구조 유도 설계Article Published on 2022-06-092022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro binding COVID-19 pandemic determinant direct-acting antiviral Direct-acting antivirals element High-resolution Host imperative in viral inhibitor inhibitors inhibitors of SARS-CoV-2 mechanism mechanism of action MERS-CoV potency potent protease public health Replication respiratory SARS-CoV-2 structures targets viral replication [DOI] 10.1021/acs.jmedchem.2c00224 PMC 바로가기 [Article Type] Article
The enzymes in COVID-19: A reviewReview article Published on 2022-06-012022-10-05 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] ACE-2 alteration biochemical cell entry receptor clinical clinical complications consequence coronavirus COVID-19 disease dysregulation Effect enzyme Enzymes Evidence in viral Initially mechanism MERS-CoV organ damage other organ outbreak pathophysiology Prognosis provided reaction Respiratory system S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutation the SARS-CoV-2 virus viral mutation Wuhan, China [DOI] 10.1016/j.biochi.2022.01.015 [Article Type] Review article