Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detectionArticle Published on 2020-09-302022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] amplification amplified Assay systems cleavage clinically complexes condition CRISPR-Cas9 genome editing detect Detection limit detection system develop DNA ENhance enhancement extension isothermal amplification lateral flow limit of detection modifications modify Molecular engineering Nucleic acid detection nucleic acid target platform reporters RT-LAMP SARS-CoV-2 RNA sensitivity Sensitivity and specificity specificity ssDNA ssRNA wild-type [DOI] 10.1038/s41467-020-18615-1 PMC 바로가기 [Article Type] Article
Modeling and forecasting the spread tendency of the COVID-19 in ChinaResearch Published on 2020-09-142022-10-28 Journal: Advances in Difference Equations [Category] COVID-19, [키워드] affected average China collected data Control strategy correlation country COVID-19 cured death effective strategy error rate Forecasting high accuracy increase key factor mathematical mathematical modeling modeling modifications modulation National Health Commission NHCC parameter Parameter estimation parameters per day Prevent SEIR significantly Spread susceptible the disease the epidemic was used [DOI] 10.1186/s13662-020-02940-2 PMC 바로가기 [Article Type] Research
SNPs or RNA modifications? Concerns on mutation-based evolutionary studies of SARS-CoV-2Research Article Published on 2020-08-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis automatically biological significance caused concern Deamination DNA Enzymes Evidence modifications Mutation mutations organism RNA RNA modification RNA virus RNA viruses RNA-seq data SARS-CoV-2 SNP virus genome [DOI] 10.1371/journal.pone.0238490 PMC 바로가기 [Article Type] Research Article
Health-Related Quality of Life and Experiences of Sarcoma Patients during the COVID-19 PandemicArticle Published on 2020-08-142022-10-31 Journal: Cancers [Category] COVID-19, [키워드] 350 patient affected benefit Cancer Care Complete COVID-19 COVID-19 infection COVID-19 pandemic emotional experience HRQoL Insomnia investigated life lockdown median age Modification modifications MOST not affected outcomes pandemic Patient Patient experience psychological support Quality Quality of life Sarcoma sarcomas significantly significantly higher Treatment with COVID-19 Worry [DOI] 10.3390/cancers12082288 PMC 바로가기 [Article Type] Article
Medical research during the COVID-19 pandemicCOVID-19 전염병 동안 의료 연구Review Published on 2020-08-062022-09-11 Journal: World J Clin Cases [Category] 비임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 affected approach best breath Care caused clinical clinical experience clinical trial Clinical trial design clinical trials collaboration Complete conduction Contact contact with contagiousness coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 pandemic Critical deaths experimental animal models flexible Follow-up Health Health care hospitals identify implementation in vitro include infections initiated involved Laboratory long term Medical research medical staff medication mental health Modification modifications MOST Novel coronavirus number of deaths pandemic participant Patient physical positive patients professional reason reported Research respiratory retroviral rights running sample sizes SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus specific treatment spread to suggested survivor therapy today Treatment Trial vaccination virus viruses with COVID-19 Wuhan Wuhan, China [DOI] 10.12998/wjcc.v8.i15.3156 PMC 바로가기 [Article Type] Review
COVID-19 Lockdown and Changes of the Dietary Pattern and Physical Activity Habits in a Cohort of Patients with Type 2 Diabetes MellitusArticle Published on 2020-08-042022-10-30 Journal: Nutrients [Category] COVID-19, MERS, [키워드] activity affected association caused change changes in Complete Consequences COVID-19 COVID-19 pandemic craving develop diet dietary dietary habit Effect exacerbated food food cravings habit Health healthy increase in involved lockdown modifications Patient patients pattern physical activity Physical inactivity promote Psychological public health Research Type Type 2 diabetes mellitus variable were used [DOI] 10.3390/nu12082327 PMC 바로가기 [Article Type] Article
COVID-19: Taiwan’s epidemiological characteristics and public and hospital responsesGlobal Health Published on 2020-06-092022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Asian Characteristics clinics close contact combating confirmed case contribute coronavirus disease 19 COVID-19 COVID-19 case COVID-19 testing death diagnostic disease epidemiological examined Face mask Health hospital Hospital wards implementation Implications infected case infected patient Mask modifications Novel coronavirus pandemic Patient Public response quarantine rate of infection reduce reported response Result SARS-CoV-2 Spread spread of COVID-19 Taiwan were infected [DOI] 10.7717/peerj.9360 PMC 바로가기 [Article Type] Global Health
COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated DemyelinationOpinion Published on 2020-06-042022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] administration alteration Antiphospholipid syndrome Autoimmune disease CNS consequence coronavirus disease COVID-19 COVID-19 disease Demyelination disease disease-modifying treatment Diseases Evidence Extended Frame health system immune pathway immune system increased alertness induce interval management modifications modify Multiple multiple sclerosis nervous Neurological diseases neurological manifestation neurologist Other pandemic Prognostic value reducing risk SARS-CoV-2 SARS-COV-2 infection sclerosis syndrome System systemic systemic lupus erythematosus the SARS-CoV-2 [DOI] 10.3390/brainsci10060345 PMC 바로가기 [Article Type] Opinion
Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistanceAspergillus fumigatus 칼슘 반응성 전사 인자는 스트레스 내성, 독성 및 카스포펀진 내성을 촉진하는 세포벽 구조를 조절합니다Research Article Published on 2019-12-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activated macrophage activated macrophages Activation aspergillosis Aspergillus fumigatus calcineurin calcium calcium metabolism Calcium signaling cause caused Cell cell wall complexity Complicating disease contribute disease disease control drug drug-resistant drugs echinocandin expression functions fungal fungal cell wall fungal cell walls fungal disease gene networks Host host infection humans identify immune response immune responses increasingly Infection influence inhibit inhibitors invasive involved killing life-threatening Localization Lungs Macrophage macrophages mechanism metabolism mice modifications modulating morphology mutant Neutrophils nine osmotic Pathogenesis Pathogens pathway phosphatase polysaccharide pro-inflammatory pro-inflammatory cytokine pro-inflammatory response pro-inflammatory responses promoted reduction in regulate regulated Regulation response responses Screen signaling pathway strain Strains Stress stress response stress response mechanisms stress responses susceptible Tolerance transcription factor transcription factors transcriptomics Treatment turn unique virulence wild-type [DOI] 10.1371/journal.pgen.1008551 PMC 바로가기 [Article Type] Research Article
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article