Proteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis폐 섬유증 환자의 COVID-19 합병증의 단백질 학 및 대사제 분석Article Published on 2021-07-162022-09-10 Journal: Scientific Reports [Category] 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] acquisition Analysis analyzed association Cell Biology Clustering collected Complication differential expression disease enrichment analysis Evidence FcγR feature fibrosis FIVE independent inflammatory pathways lesion lesions lobes lower lobe lower lobes Mechanisms of disease medical record medical records metabolites metabolomics Molecular medicine Pathogenesis pathway Pathways Patient phagocytosis PPAR signaling progression Protein proteomics pulmonary pulmonary fibrosis quantification serum biomarker serum biomarkers signaling pathway signaling pathways targeted therapy urea urea cycle were used [DOI] 10.1038/s41598-021-94256-8 PMC 바로가기 [Article Type] Article
A hybrid computational framework for intelligent inter-continent SARS-CoV-2 sub-strains characterization and prediction지능형 상호 대륙 SARS-COV-2 하위 변형 특성화 및 예측을위한 하이브리드 계산 프레임 워크Article Published on 2021-07-152022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] accelerated Amino acid Analysis analyzed Antarctica approach association Biochemistry Biotechnology Cluster cognitive cognitive approach Complete Computational biology and bioinformatics Contact tracing coronavirus database early stage early stages Gender genetics Genome genome sequence GISAID https://www.gisaid.org/ human SARS-CoV-2 hybrid increase in individual Influenza knowledge Lineage Mathematics and computing Medical research Molecular medicine nucleotide nucleotide mutation nucleotide mutations offer pathogenicity pattern performed processed protocol remained robust SARS-CoV-2 seamless Spread Strains the disease Transmission transmission route Transmission routes Viral virus [DOI] 10.1038/s41598-021-93757-w PMC 바로가기 [Article Type] Article
High-precision and cost-efficient sequencing for real-time COVID-19 surveillance실시간 CovID-19 감시를위한 고정밀 및 비용 효율적인 시퀀싱Article Published on 2021-07-012022-09-01 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amplified clade coronavirus COVID-19 COVID-19 patients COVID-19 test deaths disease disease outbreaks full-length genome coverage genomic genomic RNA Genomic surveillance High-throughput sequencing individual Los Angele Los Angeles Molecular medicine Mutation nine Nsp12 ORF8 Outbreaks platform positive Precision produced public health reduced Sanger sequencing SARS-CoV-2 sequence sequenced Sequencing sequencing data significantly Surveillance swab specimen the SARS-CoV-2 Threats Transmission USA Viral viral infection Viral RNA whole genome whole genome sequence Whole genome sequencing [DOI] 10.1038/s41598-021-93145-4 PMC 바로가기 [Article Type] Article
A novel automated SARS-CoV-2 saliva PCR test protects a global asymptomatic workforce새로운 자동화 된 SARS-COV-2 타액 PCR 테스트는 글로벌 무증상 인력을 보호합니다.Article Published on 2021-06-162022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, [키워드] AstraZeneca Asymptomatic automated COVID-19 pandemic Diagnosis Health Service Health services Infection maintain Medicine Molecular medicine Nasopharyngeal swab nasopharyngeal swabs patients PCR test PCR testing PROTECT Regular Safe Saliva SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 virus supply symptomatic individual symptomatic individuals [DOI] 10.1038/s41598-021-92070-w PMC 바로가기 [Article Type] Article
Identification of SARS-CoV-2-against aptamer with high neutralization activity by blocking the RBD domain of spike protein 1스파이크 단백질 1의 RBD 도메인을 차단하여 중화 활성이 높은 SARS-CoV-2-against aptamer의 동정Letter Published on 2021-06-102022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 치료제, [키워드] domain Drug screening identification Infectious diseases Molecular medicine neutralization activity Nucleic-acid therapeutics Spike protein the RBD Therapeutics [DOI] 10.1038/s41392-021-00649-6 PMC 바로가기 [Article Type] Letter
Covid-19 diagnosis by combining RT-PCR and pseudo-convolutional machines to characterize virus sequencesArticle Published on 2021-06-022022-10-04 Journal: Scientific Reports [Category] SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] approach caused Classifier co-occurrence Diagnosis Diagnostic method died disease DNA DNA sequence DNA sequences greater healthy identify Infection machine learning Molecular diagnosis Molecular medicine Multiple sequence alignment other coronavirus overlap pandemic public health representing resource RT-PCR SARS-CoV-2 sensitivity sequence specificity Symptoms the SARS-CoV-2 virus transmitted virus [DOI] 10.1038/s41598-021-90766-7 PMC 바로가기 [Article Type] Article
Implementing a method for engineering multivalency to substantially enhance binding of clinical trial anti-SARS-CoV-2 antibodies to wildtype spike and variants of concern proteinsArticle Published on 2021-05-182022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody antibodies antibody applied binding Biotechnology cause clinical investigation clinical trial Coronavirus-2 COVID-19 disease domain Drug discovery ENhance etesevimab immunology Implementing IMPROVE Interaction limit magnitude methodological Molecular medicine neutralization p53 Protein pseudovirus infection SARS-CoV-2 SARS-CoV-2 antibody Spike protein Spike proteins the SARS-CoV-2 Therapeutic antibody variant variants of concern viral infection viral spike protein virus wildtype [DOI] 10.1038/s41598-021-89887-w PMC 바로가기 [Article Type] Article
STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responsesArticle Published on 2021-05-142024-09-02 Journal: NPJ Genomic Medicine [Category] 대상포진, [키워드] Disease genetics Gene Expression Molecular medicine Primary immunodeficiency disorders [DOI] 10.1038/s41525-021-00196-7 PMC 바로가기 [Article Type] Article
Surge of severe acute respiratory syndrome coronavirus 2 infections linked to single introduction of a virus strain in Myanmar, 20202020년 미얀마에서 바이러스 균주의 단일 도입과 관련된 중증 급성 호흡기 증후군 코로나바이러스 2 감염 급증Article Published on 2021-05-132022-09-10 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis B.1.1 B.6 Characteristics China clade collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease disease control Diseases early phase Epidemiology Evidence evidence of FIVE genetics Genome genome analysis genomic genomic data Health India Infection information International investigated Lineage Local local spread Malaysia Microbiology Molecular biology Molecular medicine Mutation no evidence of pandemic Phylogenetic analysis Prevention strategy provide reported respiratory SARS-CoV-2 SARS-COV-2 infection second wave severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Singapore specimen Spread the SARS-CoV-2 Transmission Travel variant virus virus strain Whole-genome sequence whole-genome sequences [DOI] 10.1038/s41598-021-89361-7 PMC 바로가기 [Article Type] Article
Development of a Loop-mediated isothermal amplification (LAMP) technique for specific and early detection of Mycobacterium leprae in clinical samples임상 샘플에서 나균(Mycobacterium leprae)의 특정하고 조기 검출을 위한 루프 매개 등온 증폭(LAMP) 기술 개발Article Published on 2021-05-102024-07-29 Journal: Burma Med J [Category] 한센병, [키워드] Biological techniques Biotechnology Diseases Molecular medicine [DOI] 10.1038/s41598-021-89304-2 PMC 바로가기 [Article Type] Article