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[키워드] ACE2 acute respiratory syndrome Ad5-hACE2 airway epithelia angiotensin-converting enzyme 2 bind Calu-3 camostat Camostat mesylate caused Cell cell line cleaved coronavirus coronavirus disease COVID-19 disease pathogenesis entry of SARS-CoV-2 epithelia exhibiting greater hACE2 host cell human ACE2 in vivo Infection inhibit inhibitors initiate intranasal K18 K18-hACE2 limit lung tissue membrane fusion MERS-CoV mice Middle East Model morbidity and mortality Mortality mouse Mouse models nafamostat pandemic pathogenic coronavirus preclinical drug studies primary human airway Prophylactic protease Protease inhibitor protease TMPRSS2 Protective pulmonary receptor reduced respiratory syndrome coronavirus respiratory tract SARS-CoV-2 SARS-COV-2 infection serine protease serine protease inhibitors significantly Spike protein tested the spike protein TMPRSS2 transgenic mice Treatment viral burden weight loss
[DOI] 10.1128/mBio.00970-21 PMC 바로가기 [Article Type] Research Article