Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: Triggering a Lethal Fight to Keep Control of the Ten-Eleven Translocase (TET)-Associated DNA Demethylation?Review Published on 2020-11-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accounted activities activity acute respiratory syndrome adjacent sequences affected bimodal binding site cellular children clinical symptom complex Control coronavirus coronavirus 2 correlation COVID-19 deregulation DNA DNA methylation enzyme Factor function Gene Expression high mortality higher risk homeostasis Host hypoxia in vitro In vitro studies inactivation include intestinal Keep lethal liver mortality rate neuronal Patient patients promoters proteasomal Protein regulated Regulation Regulatory respiratory responsible SARS-CoV-2 selective Symptom Symptoms TET TET enzymes TET2 translocase viral invasion virus inactivation women X chromosome Xist [DOI] 10.3390/pathogens9121006 PMC 바로가기 [Article Type] Review
A brief review of the neurological manifestations of the coronavirus diseaseReview Published on 2020-11-232022-10-31 Journal: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery [Category] COVID-19, [키워드] abnormality Antiviral agents Autopsy Blood Cell Central nervous system cerebral cerebrospinal fluid Cerebrovascular disease Clinical studies Coagulation system Combination coronavirus coronavirus disease Coronavirus infection COVID-19 demonstrated Dexamethasone edema Encephalitis Encephalomyelitis Encephalopathy Evidence Google Scholar high mortality Immunoglobulin immunopathology infected patients Infection manifestation Miller fisher syndrome nervous system Neurological disease neurological manifestation neuronal occur olfactory Patient polymerase chain Remdesivir risk severity shown strain stroke Treatment viral damage viral encephalitis virus was done [DOI] 10.1186/s41983-020-00244-6 PMC 바로가기 [Article Type] Review
Neuronal and Cerebrovascular Complications in Coronavirus Disease 2019Pharmacology Published on 2020-11-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome affected aggravate angiotensin-converting enzyme 2 axonal transport Brain cellular component cerebrovascular Complication complications of COVID-19 consequence Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 patients Critical disease Dizziness Effect Evidence headache help highlight host cell indicate Infection knowledge loss of taste mechanism neurodegeneration Neurological complication neuronal neurons observation Occurrence Other other organs Pain pandemic disease pathobiology of COVID-19 pharmacological strategy pharmacological target problem problems respiratory tract resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein severe acute respiratory syndrome coronavirus-2 stroke suggested target the disease [DOI] 10.3389/fphar.2020.570031 PMC 바로가기 [Article Type] Pharmacology
Update on Neurological Manifestations of SARS-CoV-2Endemic Infections Published on 2020-11-062022-10-28 Journal: Western Journal of Emergency Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome alveolar cell association cause caused cell entry Central nervous system cerebrovascular accident Clinical finding clinical manifestation CNS complications coronavirus COVID-19 Cytokine storm described Effect Encephalopathy enzyme epilepsy Hypogeusia Hyposmia large vessel lung manifestation nervous system neurological Neurological symptoms neuronal neurons olfactory organ penetration Peripheral nervous system receptor reported resulting SARS-CoV-2 spread to syndrome thought thrombosis tissue venous Viral transmission virus [DOI] 10.5811/westjem.2020.8.48839 PMC 바로가기 [Article Type] Endemic Infections
Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse modelsResearch article Published on 2020-11-012022-10-05 Journal: Antiviral Research [Category] 비임상, [키워드] Abnormalities addition Anti-viral association Brain Brazil castanospermine combating CST disorders immunosuppressive property Infection Inflammation inhibiting microcephaly mouse model neurological neurological abnormalities neuronal Occurrence outbreak Outbreaks paralysis reduce reduced reported resulting Seizure Spread tissues Viral load Zika virus ZIKV [DOI] 10.1016/j.antiviral.2020.104935 [Article Type] Research article
Can Neuron Specific Enolase Be a Diagnostic Biomarker for Neuronal Injury in COVID-19?Neurology Published on 2020-10-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] accompanied acute respiratory syndrome Biomarker Brain Can cerebrospinal fluid China Clinical outcome coronavirus coronavirus disease COVID-19 COVID-19 patient CSF disease disorder elevated Encephalitis Encephalopathy hemorrhages include Infection Injury Intracerebral hemorrhage loss of taste mechanical ventilation Metastasis Mild Neuroinflammation Neurological symptom Neuron neuron specific enolase neuronal nse observation Patient patients Protein Respiratory system SARS-CoV-2 SARS-CoV2 serum stroke Symptom syndrome upper respiratory symptom while White blood cell with COVID-19 [DOI] 10.7759/cureus.11033 PMC 바로가기 [Article Type] Neurology
Encephalopathy in COVID-19 Presenting With Acute Aphasia Mimicking StrokeNeurology Published on 2020-10-192022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] Abnormalities abnormality absence acute respiratory syndrome Admission agitated Aphasia appear Brain brain MRI CAR-T cerebrospinal fluid Characteristics Chest CT clinical Complication coronavirus COVID-19 CSF Cytokine release syndrome delirium diagnosed electroencephalogram Encephalitis Encephalopathy examination expressive functional heterogeneous Hypoxemia ICANS ICU impairment intravenous low-dose manifestation mechanical ventilation Mild mimicking MRI Nasopharyngeal swab Neuroinflammation neurological Neurological deficit Neurological status Neurological symptom NEUROLOGY neuronal occur Pathogenesis Patient patients positive presenting progressed resolved reverse transcription PCR RT-PCR SARS-CoV-2 Steroids stroke subset Supportive treatment Virus Disease worsened [DOI] 10.3389/fneur.2020.587226 PMC 바로가기 [Article Type] Neurology
Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2Regular Article Published on 2020-10-082022-10-29 Journal: Toxicology Reports [Category] COVID-19, [키워드] absence Abstract ACE2 Amino acid Angiotensin-converting enzyme angiotensin-converting enzyme 2 bind binding binding affinity clinical trial Comparative complex conserved Contact COVID19 docked docking study dosage Infection inhibitory Interaction Lower neuronal Neuronal nicotinic acetylcholine receptor Nicotine patients Protein protein complex RBD domain receptor recorded reduced reducing required sACE2 sACE2 protein sACE2-INS1 complex SARS-CoV-2 SARS-CoV-2 protein sequence identity Smokers soluble ACE2 the binding affinity the healthy the SARS-CoV-2 therapeutic efficacy turn virulence [DOI] 10.1016/j.toxrep.2020.10.002 PMC 바로가기 [Article Type] Regular Article
A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunctionResearch article Published on 2020-10-012022-10-05 Journal: Brain, behavior, and immunity [Category] SARS, 임상, [키워드] acute respiratory distress airway alveolar ARDS BALF bronchial cause caused CCL2 CCR5 Cell changes in characterized clinical trial cough COVID-19 COVID-19 patient curated database dataset disease disease severity driver drug EGFR expressed Factor high risk highlight Human immune Immune cell infect Inflammation inhibitors Interaction interactions Intervention lung Mild Mortality Neuron neuronal Onset pathology patients pharmacological plasma Pneumonia promote Protein pulmonary disease pulmonary dysfunction receptor reduce reveal rheumatoid arthritis RNA sequencing SARS-COV-2 infection SARS-CoV-2 viral infection SARS-CoV-2 virus sensory neuron Severe case severe COVID-19 Shortness of breath Single Cell syndrome the disease treat [DOI] 10.1016/j.bbi.2020.05.078 [Article Type] Research article
Exercise for Older Adults Improves the Quality of Life in Parkinson’s Disease and Potentially Enhances the Immune Response to COVID-19Review Published on 2020-09-062022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] acting addition advanced age anti-inflammatory response Antiviral autonomic Cell COVID-19 COVID-19 pandemic disorder dysfunction Evidence exercise Health immune immune response immune system IMPROVE increased risk individuals Infection infection risk life literature review Medical conditions neurodegenerative disorder neuronal novel SARS-CoV-2 virus offer Older Older adults outcome outcomes Parkinson’s disease Parkinson’s disease patients performed pro-immune response Probability problem PROTECT Protective pulmonary dysfunction Quality recent response responsible SARS-CoV-2 shown substantia [DOI] 10.3390/brainsci10090612 PMC 바로가기 [Article Type] Review