Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic SuggestionsReview Published on 2021-02-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] “cytokine storm” activate Activation acute lung injury acute lung injury (ALI) acute respiratory distress acute respiratory distress syndrome (ARDS) Bacterial Bacterial coinfection characteristic characterized Combination coronavirus COVID-19 Cytokine release syndrome Cytokine storm effective eight Evidence exhibiting fungal fungal coinfection Fungal infection fungal infections healthy control hyperinflammation implication Infection Innate Innate immunity Interaction Involving Making mechanism melatonin microbes Mild mild cases mild COVID-19 patient Model NLR NLRP3 novel nucleotide-oligomer-recognition-domain-like receptors (NLR) oligomerization outlined pattern prediction receptor respiratory resulting review SARS-CoV-2 Sepsis severe COVID-19 severe COVID-19 patients suggestion Symptoms syndrome synergistic synergy therapeutic TLR TLR antagonists TLR2 TLR3 TLR4 TLR7 TLR9 Toll-like receptor toll-like receptors (TLR) treating COVID-19 [DOI] 10.3390/ijms22042108 PMC 바로가기 [Article Type] Review
Improving the quality of care in health systems: towards better strategiesCommentary Published on 2021-02-192022-10-30 Journal: Israel Journal of Health Policy Research [Category] Coronavirus, MERS, [키워드] Care complex country Course COVID 19 Critical develop element evaluate evaluated Health health system help Improving knowledge measure National outlined pandemic reactive [DOI] 10.1186/s13584-021-00448-y PMC 바로가기 [Article Type] Commentary
Hematological Abnormalities in COVID-19: A Narrative ReviewCOVID-19의 혈액학적 이상: 내러티브 검토Review Published on 2021-02-192022-09-11 Journal: The American Journal of Tropical Medicine and Hygi [Category] 바이오마커, [키워드] Abnormalities abnormality alteration alterations Biomarker blood cell Care caused changes in Coagulation common COVID-19 COVID-19 disease COVID-19 in patient D-dimer levels Effects elevated hematological hematological drug hemoglobin Hospitalization intensive care lymphopenia management manifestation mitigate narrative outlined Patient Platelet Prevent reported review SARS-CoV-2 severe COVID-19 disease significantly more Symptoms therapy thrombocytopenia toxicities Toxicity White blood cell [DOI] 10.4269/ajtmh.20-1536 PMC 바로가기 [Article Type] Review
Beyond Individual Triage: Regional Allocation of Life-Saving Resources such as Ventilators in Public Health EmergenciesOriginal Article Published on 2021-02-062022-10-31 Journal: Health Care Analysis [Category] Coronavirus, MERS, SARS, [키워드] allocation approach coronavirus country COVID-19 pandemic Emergency First wave healthcare healthcare worker individual limitation outlined pandemic Patient Public public health public health emergency question raised receive Region Regional resource Resource allocation translate Treatment ventilator ventilators [DOI] 10.1007/s10728-020-00427-5 PMC 바로가기 [Article Type] Original Article
Anticipated health effects and proposed countermeasures following the immediate introduction of telework in response to the spread of COVID‐19: The findings of a rapid health impact assessment in JapanField Study Published on 2021-02-022022-10-29 Journal: Journal of Occupational Health [Category] Coronavirus, [키워드] added applicability applied Care Community conducted COVID‐19 COVID‐19 determine disease Effect Effects ENhance evaluate FIVE group groups Health Health Impact Assessment implementation introduced Japan likelihood management mitigate Nurses objective outlined pandemic physician positive Result screened Spread telework Validity website Working from home [DOI] 10.1002/1348-9585.12198 PMC 바로가기 [Article Type] Field Study
Variability in instructions for performance of nasopharyngeal swabs across Canada in the era of COVID-19 – what type of swab is actually being performed?COVID-19 시대에 캐나다 전역에서 비인두 면봉 수행 지침의 변동성 – 실제로 어떤 유형의 면봉이 수행되고 있습니까?Original Research Article Published on 2021-01-282022-09-12 Journal: Journal of Otolaryngology - Head & Neck Surgery [Category] 진단, [키워드] Abstract Canada CDC center collected Control COVID-19 disease control distance ear canal Edward effective England estimation external ear Guidance health authorities Health authority Health Organization heterogeneity identify insertion instruction island journal majority Medicine nasal passage nasal passages Nasopharyngeal swab nasopharyngeal swabs nasopharynx New Northwest Territories nose nostril nostrils Nova Nunavut organization outlined PAHO palate Pan pictogram prevention Prince provided public health Regional Result SARS-CoV-2 Screening supplementary material Surveillance Swab technique Turbinate was performed [DOI] 10.1186/s40463-020-00490-x PMC 바로가기 [Article Type] Original Research Article
Analysis of the Different Approaches Adopted in the Italian Regions to Care for Patients Affected by COVID-19Article Published on 2021-01-202022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] adopted Analysis approach approaches carried contributed Course COVID-19 COVID-19 emergency deaths epidemic outbreak phases Health health system highlighting home-based care hospital hospital care Hospitalization ICU in-depth analysis infection rate Italian Italian region Italian regional health systems later phase Lazio Local lockdown Lombardia majority management National outbreak outlined pandemic Patient professional reduce Region the epidemic Treatment Veneto [DOI] 10.3390/ijerph18030848 PMC 바로가기 [Article Type] Article
Testing the efficacy and safety of BIO101, for the prevention of respiratory deterioration, in patients with COVID-19 pneumonia (COVA study): a structured summary of a study protocol for a randomised controlled trialCOVID-19 폐렴 환자에서 호흡 악화 예방을 위한 BIO101의 효능 및 안전성 테스트(COVA 연구): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-112022-09-10 Journal: Trials [Category] 임상, [키워드] 1:1 20-hydroxyecdysone absence accumulation ACE2 Activation acute respiratory distress acute respiratory distress syndrome adaptive addition administration Airway Pressure all-cause mortality ALT Alter amenorrhea Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme-2 Anti-inflammatory anticipated approved ARDS arterial oxygen saturation AST Asymptomatic balance baseline being Belgium beneficiary Bilirubin BIO101 Biomarker Biomarkers birth control blinded Brazil breath Cardiomyopathy Care Caregivers caused clinical development Clinical finding Clinical findings clinical picture co-morbidities co-morbidity collected Compliance condition condom conducted confirmation Consumption Continuous Continuous Positive Airway Pressure Contraception contraceptive method coronavirus disease COVID-19 COVID-19 infection COVID-19 infection symptom COVID-19 infection symptoms COVID-19 patient COVID-19 patients criteria criterion daily dose Day death defined Department Deterioration develop diabetes diagnosis of COVID-19 dialysis discharge discharged disease dissemination DMC dose double-blind downstream ECMO Effect effective Efficacy Efficacy and safety EGFR element eligible participant Eligible participants endotracheal tube Endpoint enzyme etonogestrel EudraCT European evaluate event Evidence evidence of exclusion criteria expected exploratory extracorporeal membrane oxygenation female female participants Final FiO2 Flow following form France French functional Gault Gender healthcare healthcare facility heart disease High-flow oxygen higher risk hospital hospital care Hospitalization Hospitalized hypersensitivity hypertension IBM ICF Imbalance include Inclusion independent indication Infection Inflammation informed consent form injection Interim analyses interim analysis Intervention intrauterine device Intubated Invasive mechanical ventilation IWRS system lactating limit Liver function liver function tests male participants marker Mas receptor maximum measure mechanical ventilation medical intervention medication medications minute moderate morbidities Moribund Mortality mouth Multiorgan dysfunction muscles myocarditis negative urine pregnancy test Non-COVID-19 number obesity objective observation offer Older oral contraceptive outcome outlined oxygen Part participant partner pathway Pathways patients with COVID-19 patients with SARS-CoV-2 PCR performed Pericarditis Physical examination Placebo placebo-controlled Pneumonia positive airway pressure post-intervention post-menopausal powder pregnancy test pressure primary endpoint proof proportion Proportion of participant protocol public health randomised randomised controlled trial randomization RAS reached receive receiving receptor recruited recruitment Registered renal renal disease renal insufficiency Renin renin angiotensin system renin-angiotensin system reproduction required resource respiratory Respiratory distress syndrome Respiratory failure Respiratory function respiratory symptoms restored risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 spike protein second secondary secondary endpoint security severe pneumonia Shock Social Security specimen Sperm Spike protein SpO2 Statistical power status Sterilization Stratification stratified study medication Study protocol supplementary material survival suspicion Symptom syndrome tachypnea target population tested Testing the primary endpoint therapeutic therapeutic option tissue Tolerability Total total bilirubin Treatment treatment arm treatment period Triage Trial Trial registration ULN Urine USA variety vasectomy Version Viral load water website [DOI] 10.1186/s13063-020-04998-5 PMC 바로가기 [Article Type] Letter
Monitoring the impact of COVID-19 pandemic on mental health: a public health challenge? Reflection on Italian dataCOVID-19 전염병이 정신 건강에 미치는 영향 모니터링: 공중 보건 문제? 이탈리아 데이터에 대한 반성Article Published on 2021-01-012022-09-11 Journal: Social psychiatry and psychiatric epidemiology [Category] SARS, 치료기술, [키워드] activated addition Admission Analysis antidepressant anxiety symptom Care COVID-19 epidemic COVID-19 pandemic depressive Effect followed by General population Google greater help Hospitalization increase in individual Intervention Italian Italian population Italy lockdown lombardy Medicine Medicines Mental mental health Ministry of Health monitoring outlined pandemic Prevalence protection Psychiatric psychological support Psychological well-being public health reduction in Reflection reported request request for Research significant increase telephone number [DOI] 10.1007/s00127-020-01971-0 PMC 바로가기 [Article Type] Article
Investigating the challenges and opportunities for medicines management in an NHS field hospital during the COVID-19 pandemicArticle Published on 2021-01-012022-10-04 Journal: European Journal of Hospital Pharmacy [Category] 신약개발, [키워드] adjusted Admission affecting Analysis anticipated applied approach Care clinical pharmacy competency competency evaluation COVID-19 COVID-19 disease COVID-19 pandemic disease drug formulary management element Factor Health services hospital hospitals identify implementation Infectious diseases internal investigated management mechanism Medicine Mild moderate National Health Service NHS opportunity Organisation of health services outlined pandemic Patient respond resulting Support treat [DOI] 10.1136/ejhpharm-2020-002364 PMC 바로가기 [Article Type] Article