Network-based transcriptomic analysis identifies the genetic effect of COVID-19 to chronic kidney disease patients: A bioinformatics approachResearch article Published on 2021-10-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, [키워드] Actin Analysis analyzed approach ARHGEF12 Aspirin BCL2L1 bioinformatics CAV1 chronic Chronic kidney disease CKD Comorbidity COVID-19 COVID-19 patient DEGs detect differentially expressed gene drug E2F1 EPHB2 gene signature Genetic Health high risk HSP90B1 hub protein identify infected with SARS-CoV-2 Infection Interaction investigated ITGA2B Kidney disease microRNA molecular pathways mononuclear cell Ontology pathway Patient patients PBMC Peripheral blood PPI PRKAR2B protein-protein interaction Rapamycin regulate SARS-CoV-2 Systems biology the SARS-CoV-2 therapeutic target Threats transcription factor Transcriptional signature transcriptomic transcriptomic analysis transcriptomic data TUBB1 [DOI] 10.1016/j.sjbs.2021.06.015 [Article Type] Research article
The host immune response of a discharged COVID-19 patient with twice reemergence of SARS-CoV-2: a case reportSARS-COV-2의 두 번 재발을 갖는 퇴원 된 COVID-19 환자의 숙주 면역 반응 : 사례 보고서Case Reports Published on 2021-09-232022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Case report caused Cell cell count coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Diagnosis discharged during treatment global pandemic help hospital Host immune response host immune system IgG Immunoglobulin Immunoglobulin G Infection initial mechanism mononuclear cell Patient PBMC Peripheral blood positive proportion Protective Re-infection Reemergence reported respiratory RNA test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serum severe acute respiratory syndrome Coronavirus suggested T cell T cells tested the cell the patient Treatment treatment of COVID-19 virus [DOI] 10.1186/s12879-021-06679-3 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril)Immunology Published on 2021-09-202022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE ACE2 activated Activation Analysis analyzed angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Apoptosis binding Blood Cell cells changed circulation component conditioned media coronavirus CoV cytokine expression Effect Effects Endothelial cell entry of SARS-CoV-2 expression glycoprotein HUVEC cells increase in Inflammation Inflammatory marker inhibitor intracellular calcium intracellular cytokine involved Local Macrophage macrophage polarization macrophages MCP-1 MHC-II modulation monocyte/macrophages mononuclear cell oxidative stress pathway PBMC PBMCs Perindopril Peripheral blood phenotype Potential proinflammatory Proteins Proteomic analysis purified receptors reduced regulated response role ROS S protein SARS-CoV-2 sensitivity significantly increased spike Spike protein stimulated Stimulation systemically the S protein THP-1 TNFα treating Treatment upregulation Vascular viability was used [DOI] 10.3389/fimmu.2021.728896 PMC 바로가기 [Article Type] Immunology
Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)Articles Published on 2021-09-112022-10-30 Journal: Lancet (London, England) [Category] COVID-19, [키워드] 95% CI Academy analyses antibodies antibody Antibody titre antibody titres AstraZeneca AZD1222 baseline boost booster ChAdOx1 nCoV-19 Chinese Clinical research Coalition Cohort Controlled trial Council country COVID-19 vaccine dose Efficacy ELISA Engineering enrolled extended interval finding first dose funding geometric mean titre IgG Immunity immunogenicity data induce Innovation IQR ISRCTN median Medical Science mononuclear cell network NIHR Oxford participant PBMC Peripheral blood persistence phase 2/3 prime-boost interval randomised controlled trial reactogenicity Registered remained Science second dose SFU significantly higher single dose South supply shortage T-cell Response T-cell responses T-cells responses the vaccine titre vaccination Vaccine Valley viral particle Volunteer [DOI] 10.1016/S0140-6736(21)01699-8 PMC 바로가기 [Article Type] Articles
Enrichment of SARS-CoV-2 Entry Factors and Interacting Intracellular Genes in Tissue and Circulating Immune CellsSARS-COV-2 진입 인자의 농축 및 조직에서 세포 내 유전자 상호 작용 및 순환 면역 세포Article Published on 2021-09-022022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Cell circulating circulation COPI COPII COVID-19 patient datasets dendritic cells enrichment Express Factor Factors fraction gene enrichment Genes GTPases healthy Host Immune cell immune cells infect Integrins Interaction Intracellular lifecycle Lungs machine learning algorithm Machine learning algorithms macrophages mechanism of action Monocytes mRNA translation nasal not express Patient PBMC Proteins required Research RHOA SARS-CoV-2 shown significantly T cells the cell the SARS-CoV-2 tissue tissues TMPRSS2 Transport Viral [DOI] 10.3390/v13091757 PMC 바로가기 [Article Type] Article
Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응Research Article Published on 2021-09-022022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 유전자 메커니즘, [키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses [DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article
Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)어린이의 다기관 염증 증후군(MIS-C)에 대한 유전적 감수성의 기본 메커니즘Article Published on 2021-09-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Apoptosis Beta cardiovascular dysfunction characterized children cohort of patient condition coronavirus COVID-19 CYBB cytokine cytokine signaling Deleterious develop Diagnosis differentially expressed gene Differentially expressed genes downstream enrichment enrolled Exome General population Genetic genetic mechanism genetic risk factor genetic susceptibility had no haploinsufficiency healthy children identify IL-18 Immune cell Including Infection Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibitor interferons interquartile range median age Mild MIS-C Multiorgan multisystem inflammatory syndrome in children Next-generation sequencing nuclear obesity occur pathway Pathways Patient PBMC PBMCs pediatric prospective cohort study reported respiratory SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus single-center SOCS1 subunit Support suppressor susceptibility syndrome Transcriptome type I variant was performed was tested whole exome sequencing X-linked XIAP [DOI] 10.1016/j.jaci.2021.06.024 PMC 바로가기 [Article Type] Article
Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes기존 제2형 당뇨병과 SARS-CoV-2 감염에 대한 시너지적 복잡성의 분자적 통찰력 확인Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] activities Analysis analyzed approaches association bioinformatics BIRC3 caused Cell Comorbidities Comorbidity conditions contributing to COVID-19 COVID-19 outbreak CREB3L1 cytokine cytokine receptor DEGs detect determine diabete diabetes differentially expressed gene Differentially expressed genes Disease progression drug drug candidate drug candidates Drug molecules enrichment enrichment analyses evaluated expressed Factor followed by FOSL1 Functional enrichment analysis Genetic genetic determinant genetic factors global public health Health identify identifying IL-17 IL1B Interaction IRF1 islet cell KLF11 let-7b-5p lung epithelium cell lung epithelium cells microRNA MicroRNAs miR-1 miRNA miRNAs MME molecular overlapped pancreatic pancreatic islet Pathways Patient PBMC PBMCs PPI prevalent protein-protein interaction protein–protein interactions receptor Research SARS-CoV-2 SARS-COV-2 infection severity severity of COVID-19 significant pathway significant pathways synergistic T2D TFS the disease therapeutic intervention TNF transcription factor transcription factors transcriptomic data Type type 2 diabete type 2 diabetes [DOI] 10.1016/j.compbiomed.2021.104668 PMC 바로가기 [Article Type] Article
Host Genetics and Antiviral Immune Responses in Adult Patients With Multisystem Inflammatory Syndrome다기관 염증 증후군이 있는 성인 환자의 숙주 유전학 및 항바이러스 면역 반응Immunology Published on 2021-08-312022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] affected affecting analyzed antibody autoantibody autophagy characteristic children classical contributing to Coronavirus disease 2019 Course COVID-19 CXCL10 cytokine Cytokines description disease disease-causing DNA ELISA Exome expression Features FIVE Genetic hallmark hallmarks healthy controls IFNα IL-1β IL-6 immune responses immunological in vitro In vitro infection Inflammatory interferon interferon response interferons Kawasaki disease less MIS mononuclear cell mononuclear cells Multiorgan dysfunction Multisystem inflammatory syndrome organ Pathogenesis Patient patients PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells Presence Proinflammatory cytokine proinflammatory cytokines reduced response restriction factor SARS-CoV-2 SARS-COV-2 infection Sequencing Sequencing analysis syndrome systemic inflammation TNFα type I type I and III interferons variant WES whole exome sequencing [DOI] 10.3389/fimmu.2021.718744 PMC 바로가기 [Article Type] Immunology
Effects of long-term cryopreservation of PBMC on recovery of B cell subpopulationsarticle Published on 2021-08-312024-09-01 Journal: Nursing Reports [Category] 파상풍, [키워드] B cells cryopreservation Human memory B cells PBMC [Article Type] article