Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction감산 단백질체학 보조 치료 표적 마이닝 및 면역 반응 유도를 위한 Candida auris에 대한 앙상블 백신 설계Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] antigenic approach B cell Candida Candida auris candidate caused characterization Co-infection COVID-19 COVID-19 patient CTL demonstrated effective effective therapy Efficacy feature global pandemic HTL IgG IgM IL-6 immune immune response Immune simulation immunogenic peptide in-silico Infection infections interferon Interferon-α molecular docking Multi-epitope vaccine non-allergenic peptides producing proteome proteomics provide SARS-CoV-2 Seven Subtractive proteomics target targets the vaccine therapeutic target therapeutic targets threshold Vaccine vaccine candidate vaccine candidates Vaccines validation variant variants was performed [DOI] 10.1016/j.compbiomed.2022.105462 PMC 바로가기 [Article Type] Article
CAVES: A Novel Tool for Comparative Analysis of Variant Epitope SequencesCAVES: 변이 에피토프 서열의 비교 분석을 위한 새로운 도구Article Published on 2022-05-262022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy Analysis antigenic antigenic variation approach bioinformatics categories category coding Comparative Comparative analysis Comparative genomics comparison Computational biology database epitope Epitope prediction Epitopes Evolution fraction Github graphical user interface IEDB immune IMPROVE novel open-source software pathogen Pathogens peptide peptides reducing required SARS-CoV-2 variant SARS-CoV-2 variants sequence Sequence analysis source code speed subject test dataset therapeutic user interface Vaccine variant window [DOI] 10.3390/v14061152 PMC 바로가기 [Article Type] Article
Circularized fluorescent nanodiscs for probing protein-lipid interactions단백질-지질 상호작용을 조사하기 위한 원형 형광 나노디스크Article Published on 2022-05-262022-09-11 Journal: Communications Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] binding biochemical events fluorescent fusion peptide GFP HIV-1 intensity Interaction involved membrane neurotransmission peptides Protein Reactions Research respond robust SARS-CoV-2 Signal transduction signaling pathways synaptotagmin synuclein translational transmembrane [DOI] 10.1038/s42003-022-03443-4 PMC 바로가기 [Article Type] Article
SM-COLSARSPROT: Highly Immunogenic Supramutational Synthetic Peptides Covering the World’s PopulationSM-COLSARSPROT: 전 세계 인구를 대상으로 하는 고 면역원성 초돌연변이 합성 펩타이드Article Published on 2022-05-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Amino acid Antibody titre Antigen presentation approach backbone complementary concerning Coverage Covering disrupting DNA E protein genetic variability Genetic variant genotyped histocompatibility complex human leukocyte antigen immune response induce Interaction leukocyte major histocompatibility complex methodology MHCII modified synthetic peptides molecular multiepitope mutant mutational variants Neutralising Antibodies neutralising antibody pandemic parental peptide peptides physicochemical polymorphism Population predicted replacing residues SARS-CoV-2 SARS-CoV-2 S selected Specific Structure supramutational synthesised synthetic synthetic peptides Trial Vaccine development vaccine for COVID-19 virus worldwide coverage. π-π interaction [DOI] 10.3389/fimmu.2022.859905 PMC 바로가기 [Article Type] Article
Bomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped VirusesBomidin: 외피 바이러스에 대한 광범위한 항바이러스 활성을 가진 최적화된 항균 펩티드Article Published on 2022-05-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Against AMP AMPs antibiotic antimicrobial antimicrobial peptide antimicrobial peptide. antimicrobial peptides AVP Bacteria Bacterial bovine Chikungunya Chikungunya virus CHIKV Coronavirus-2 Defense Dengue dengue virus DENV-2 disrupt Escherichia coli Evolution expressed expression extraction front line fungi global public health herpes simplex herpes simplex virus heterologous expression HSV-2 life-threatening lipids mechanism membrane membranes methionine molecular offer organism overcome pathogen Pathogens peptide peptides produced purification Research SARS-CoV-2 sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus therapeutic variety virus viruses [DOI] 10.3389/fimmu.2022.851642 PMC 바로가기 [Article Type] Article
A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants멀티토프 SARS-CoV-2 백신은 Delta 및 Omicron 변이체에 대해 오래 지속되는 B 세포 및 T 세포 면역을 제공합니다Clinical Trial Published on 2022-05-162022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] adverse event Antibody titers Asia B cell booster Breakthrough infection breakthrough infections center conducted conserved Control COVID-19 cross-reactive cytotoxic T lymphocyte Delta disease control dose elicited epitope Epitopes evaluated fatigue healthy helper T cell Heterologous human convalescent sera Immunity immunization immunogenicity Inc. injection site pain long-lasting lymphocyte membrane memory immunity Mild Ministry of Health Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers Neutralizing titer nucleocapsid omicron Omicron variants peptide peptides Phase I placebo-controlled Protein provide Randomized representing responsible safety profile sarbecovirus SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants second dose Serious Adverse Event Serious Adverse Events subunit Subunit vaccine T cell Taiwan Trial trials Vaccine variant variants of SARS-CoV-2 virus-neutralizing antibody VOCs waning immunity Welfare were recorded [DOI] 10.1172/JCI157707 PMC 바로가기 [Article Type] Clinical Trial
Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigensCD8+ T 세포 병원성 에피토프 및 암 신생항원 예측에서 기존 컴퓨터 모델의 성능 평가Article Published on 2022-05-132022-09-12 Journal: Briefings in Bioinformatics [Category] MERS, 진단, [키워드] acute respiratory syndrome binding affinity Cancer cancer neoantigen cancers CD8 T-cell CD8 T-cell target CD8+ T cell coronavirus disease distribution epitope evaluated Evaluating Evidence facilitate Factor feature highlight histocompatibility complex HLA ligand immunogenic immunogenic peptide immunotherapies Immunotherapy Intensive long-term immune responses malignant cell modulate offer parameter pathogen pathogenic pathology peptide peptide immunogenicity peptide presentation peptides predictors question random Research robust stability suggested T cell T cell receptor T-cell T-cell Response target threshold training data Vaccine Variation virus [DOI] 10.1093/bib/bbac141 PMC 바로가기 [Article Type] Article
Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the “Green Pass” Policy다양한 COVID-19 백신에 대한 체액 면역 반응 다양성: "그린 패스" 정책에 대한 시사점Article Published on 2022-05-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE2 binding activities Ad26 Ad26.COV2.S age Analysis anti-RBD anti-RBD antibody titer antibody Antibody Response Antibody titer appear assumption average binding BNT162b2 booster vaccination ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine ChAdOx1 nCoV-19 vaccines concentrations country COV2.S COVID-19 COVID-19 infection COVID-19 pandemic detect Diversity elicit elicited eligibility epitope evaluated Features green Green Pass Policy heterogeneous humoral humoral immune response immune Immunity implication individual maintain mRNA mRNA-1273 Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody observé Pass peptides Policy Protein Randomly Rapid test rationale RBD RBD-ACE2 reactivity reactogenicity Receptor-binding domain reduce reopening response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike selected sera serum serum sample significantly spike Spike protein synthetic peptide the receptor-binding domain titer vaccinated individual vaccination Vaccine virus spread [DOI] 10.3389/fimmu.2022.833085 PMC 바로가기 [Article Type] Article
Deficiency of SARS-CoV-2 T-cell responses after vaccination in long-term allo-HSCT survivors translates into abated humoral immunity장기 allo-HSCT 생존자에서 백신 접종 후 SARS-CoV-2 T-세포 반응의 결핍은 체액성 면역 감소로 해석됩니다Article Published on 2022-05-102022-09-11 Journal: Blood advances [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allo-HSCT Allogeneic allogeneic hematopoietic stem cell transplantation Amino acid analyzed anti-RBD BNT162b2 Control coronavirus COVID-19 COVID-19 vaccines death deficiency detectable determine disease Ex vivo Fisher Fisher's exact test healthy control hematological Hematopoietic stem cell HSCT Humoral immunity humoral responses IgG immunogenicity Immunoglobulin Immunoglobulin G interferon interferon-γ lack median mRNA mRNA-1273 Odds ratio of BNT162b2 overlap Patient peptide peptides rate of seroconversion RBD reactivity Receptor binding domain recipient recipients reflected respiratory risk S1 IgG SARS-CoV-2 second vaccination Seroconversion seronegative serum severe acute respiratory syndrome Coronavirus severe disease significantly lower stem cell Stem cell transplantation stimulated substandard survivor T-cell T-cell immunity T-cell Response T-cell responses translate transplantation vaccination Vaccinations vaccine dose Whole blood [DOI] 10.1182/bloodadvances.2021006937 PMC 바로가기 [Article Type] Article
Immunogenic epitope panel for accurate detection of non-cross-reactive T cell response to SARS-CoV-2SARS-CoV-2에 대한 비교차 반응성 T 세포 반응의 정확한 검출을 위한 면역원성 에피토프 패널Article Published on 2022-05-092022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 치료기술, [키워드] absence Accuracy Antigen antigens association Asymptomatic clinical clinical trial clinical trials Cohort collected Combination Complete contributing to convalescent COVID-19 COVID-19 pandemic cross-reactive described diagnostic Diagnostic accuracy diagnostic specificity donors effective epitope Epitopes exclusion full-length healthy HLA HLA allele Immune cell immune cells immunodominant immunogenic immunogenicity in vitro independent individual individuals offered peptides PROTECT reactivity robust SARS-CoV-2 SARS-CoV-2 immunity sensitivity seronegative specificity T cell T cell response T cells [DOI] 10.1172/jci.insight.157699 PMC 바로가기 [Article Type] Article