phenotypic – Page 10 – Communicable Diseases Research

Permethrin resistance in Aedes aegypti : Genomic variants that confer knockdown resistance, recovery, and death

Aedes Aegypti의 퍼메 트린 저항 : 녹다운 저항, 회복 및 사망을 부여하는 게놈 변이체

Research Article

Published on 2021-06-172022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Alterations in T and B cell function persist in convalescent COVID-19 patients

회복 중인 COVID-19 환자에서 T 및 B 세포 기능의 변화가 지속됨

Clinical and Translational Report

Published on 2021-06-112022-09-14
Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단,

[키워드] Abstract Activation acute COVID-19 Affect alteration B cell B cell subset B cells breathlessness caused CD8 change changes in Characteristics Clinical outcome clinical outcomes conducted Context contribute convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus disease COVID-19 COVID-19 patient cytokine defined disease Effect elevated Evidence examined fatigue finding Frequency functional funding Giving groups Health hospital discharge Hospitalization hospitalized COVID-19 patient identify IL-10 IL-17 IL-6 immune response Infection Long COVID longer-term immunity Lung disease Lung pathology lymphocyte Medicine Novel coronavirus outcome pandemic parameter Patient persistence phenotype Phenotypes phenotypic Population pro-inflammatory receptor restored skewed subgroup subgroups subsequent Symptom Symptoms T cell T cells Trust viral infection Wellcome Trust with COVID-19
[DOI] 10.1016/j.medj.2021.03.013 PMC 바로가기 [Article Type] Clinical and Translational Report

Deliberate paradigm shift in research in rare neurodevelopmental disorders

Letter to the Editor

Published on 2021-06-092022-10-29
Journal: Orphanet Journal of Rare Diseases [Category] Coronavirus, MERS, SARS,

[키워드] activities activity affected age children Community complex Coverage COVID-19 pandemic creating Critical disorder disorders ecological effective effort IMPROVE individual International management phenotypic platform Research Standardization Support Treatment Variation
[DOI] 10.1186/s13023-021-01885-3 PMC 바로가기 [Article Type] Letter to the Editor

Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus

Aspergillus fumigatus의 COVID-19 관련 폐 아스페르길루스증 분리물의 게놈 및 표현형 분석

Research Article

Published on 2021-06-092022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 유전자 메커니즘,

[키워드] A. fumigatus acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed aspergillosis Aspergillus Aspergillus fumigatus caused Cell cell wall Characteristics characterized Coinfection conducted copy number copy number variant Copy number variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient deleted described drugs etiological agent example expand Factors fungal disease fungal pathogen fungal pathogens genetic determinant Genome Genome sequencing genomes genomic genus Germany global pandemic growth had more information isolate isolates loss-of-function mutation metabolite microbial modulate mutational spectrum North nucleotide osmotic outcome oxidative pathogenicity Pathogens patients treated Phenotypes phenotypic Polymorphisms profile pulmonary pulmonary aspergillosis reference strain reference strains reported respiratory responsible SARS-CoV-2 Secondary infection secondary infections Secondary Metabolite severe acute respiratory syndrome Coronavirus significant difference significant differences significantly more single nucleotide polymorphisms strain Strains stressors subset superinfection virulence virulence factors virulent Wuhan Wuhan, China
[DOI] 10.1128/Spectrum.00010-21 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 variants lacking ORF8 occurred in farmed mink and pangolin

ORF8이 결여된 SARS-CoV-2 변종은 양식 밍크와 천산갑에서 발생했습니다

Article

Published on 2021-06-052022-09-11
Journal: Gene [Category] SARS, 변종,

Application of a High-Content Screening Assay Utilizing Primary Human Lung Fibroblasts to Identify Antifibrotic Drugs for Rapid Repurposing in COVID-19 Patients

Article

Published on 2021-06-022022-10-04
Journal: SLAS discovery : advancing life sciences R & D [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] 384-well format acute respiratory syndrome Analysis antifibrotic antifibrotic therapy Apoptosis application applied approved drug automated Autopsy Candidates Cell cell differentiation Confirmed COVID-19 COVID-19 pandemic COVID-19 patient current Data analysis Diseases drug ECM effective elevated Extracellular matrix fibroblast fibrosis growth hallmark Health high-content screening Human human lung lung Lung fibrosis medical need Middle East Migration mitigate Mortality network analysis pathway phenotypic phenotypic drug discovery previous study Prognosis proliferation Rapid representing repurposing respiratory disorder scarring screened Screening small molecule syndrome therapeutic Treatment ventilator with COVID-19
[DOI] 10.1177/24725552211019405 PMC 바로가기 [Article Type] Article

In vitro activity of itraconazole against SARS‐CoV‐2

Research Article

Published on 2021-05-252022-10-04
Journal: Journal of medical virology [Category] SARS, 신약개발, 치료제,

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibility

인간 질병과 분자 표현형의 공유 유전 구조를 연결하는 아틀라스는 COVID-19 감수성에 대한 통찰력을 제공합니다

Software

Published on 2021-05-172022-09-10
Journal: Genome Medicine [Category] SARS, 유전자 메커니즘,

[키워드] ABO Analysis application association Bacterial infection Biomarker calculate capture CD209 cellular clinical utility Colocalization common diseases complex COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 susceptibility Cross-phenotype association database DC-SIGN demonstrated Diseases DPP9 driven by enrichment examined explain exploration facilitate fibrosis genetic architecture Genetic variation genome-wide association glycosylation Gout GWAS GWAS summary statistics healthy control healthy controls Hi-HOST human disease human diseases hypothese hypotheses identify Idiopathic pulmonary fibrosis information LD-score lead Linkage disequilibrium locus Macular telangiectasia mechanism molecular molecular phenotype overlap pathophysiology Peripheral blood Phenotypes phenotypic PheWAS plasma protein Pleiotropy portal provide pulmonary fibrosis receptor regulate reported Result rs12610495 rs2869462 rs505922 SARS-CoV-2 severe COVID-19 SIGN SNP supplementary material therapeutic approaches traits transcriptomics translation while
[DOI] 10.1186/s13073-021-00904-z PMC 바로가기 [Article Type] Software

Current Strategies of Antiviral Drug Discovery for COVID-19

Molecular Biosciences

Published on 2021-05-132022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] 3CL pro accessory proteins acute respiratory syndrome anti-coronavirus activity antibody anticipated antiviral agent antiviral drug antiviral drugs antiviral strategy approved artificial intelligence asymptomatic infection betacoronaviruses can be used catalytic site cause cellular receptor China circulating Clinical effect common cold conserved Coronaviridae coronavirus COVID-19 COVID-19 disease COVID-19 epidemic current deaths develop direct-acting antiviral disease drug Drug discovery drugs drugs targeting effort ENCODE engage enzyme etiological agent fatality Genome genomic sequence HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 Helicase High Throughput Screening highlight host-targeting antiviral identify immuno-regulator in viral in vitro in vivo include infections Infectious disease involved Jin membrane MERS MERS-CoV Mild monoclonal antibodies morbidity and mortality Neurological disease neutralizing antibody new treatment strategy non-structural protein outbreak pandemic pandemic disease Papain-like protease peptides phenotypic Prevent previous study protease public health RdRP recognize Region Remdesivir Replication reported respiratory syndrome coronavirus RNA virus RNA-dependent RNA polymerase SARS CoV SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 severe pneumonia severity shown similarity spike glycoprotein strain Strategy structural protein structural proteins Structure target the disease the epidemic the SARS-CoV-2 Transcription treating COVID-19 upper respiratory tract urgency US FDA viral entry viral infections viral infectious disease WHO World Health Organization
[DOI] 10.3389/fmolb.2021.671263 PMC 바로가기 [Article Type] Molecular Biosciences

Germline risk of clonal haematopoiesis

Reviews

Published on 2021-05-132022-10-05
Journal: Nature reviews. Genetics [Category] 바이오마커,