Clinical significance of cellular immunity function and inflammatory factors assays in alveolar lavage fluid for severe COVID‐19 pneumoniaResearch Article Published on 2021-02-092022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 바이오마커, [키워드] affecting alveolar alveolar lavage fluid assessment assigned C‐reactive protein CD3 CD4 CD8 Cell cell count cells cellular immunity change chronic clinical impact Clinical significance collected correlated COVID‐19 COVID‐19 death group disease severity failure flow cytometry hypersensitive ICU admission IL‐6 immunoturbidimetry independent risk factor Inflammatory factor inflammatory factors intensive care Lymphocyte subset Patient PCT Peripheral blood Physiology Pneumonia procalcitonin Prognosis serum severe patients severity significantly higher SOFA SOFA score statistically survival group [DOI] 10.1002/jmv.26827 PMC 바로가기 [Article Type] Research Article
Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathyCOVID-19 관련 전신 미세혈관병증 환자에서 이중 에너지 컴퓨터 단층 촬영으로 진단된 폐 및 신장 관류 장애Article Published on 2021-02-012022-09-11 Journal: European Radiology [Category] 치료기술, [키워드] abnormality Admission albumin Anticoagulant Anticoagulants aspartate Aspartate aminotransferase AUROC C-reactive protein Characteristics Computed tomography Computed tomography angiography consolidation coronavirus coronavirus disease COVID-19 COVID-19 patients cutoff value D-dimer D-dimer level D-dimer levels diagnosed disease severity eight evaluated Evidence fibrinogen ground-glass opacity help heterogeneous Hospital stay Hypoxemia implication indication intensive care investigated Iodine kidney kidneys Laboratory laboratory findings lung management Mild-to-moderate occur overlapping Oxygenation Patient patients patients with COVID-19 Perfusion Physiology plasma predicted proportion pulmonary Pulmonary embolism Pulmonary thromboembolism sensitivity Serum ferritin severe disease SIGN significantly higher sodium sodium level specificity systemic microangiopathy Thromboembolism Thromboprophylaxis thrombosis thrombotic thrombotic event Thrombotic events tomography troponin troponin level troponin levels [DOI] 10.1007/s00330-020-07155-3 PMC 바로가기 [Article Type] Article
Sex differences in immune responses to SARS-CoV-2 in patients with COVID-19COVID-19 환자에서 SARS-CoV-2에 대한 면역 반응의 성별 차이Immunology & Inflammation Published on 2021-01-292022-09-12 Journal: Bioscience Reports [Category] 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine alanine aminotransferase ALT analyzed APACHE II aspartate Aspartate aminotransferase AST Biomarkers C-reactive protein C-reactive protein (CRP CD3 CD4 CD8 chronic circulating clinical feature Clinical features clinical manifestation clinical manifestations Cohort community-acquired pneumonia coronavirus correlation COVID-19 COVID-19 patient COVID-19 patients CRP Decreased diagnosed Estrogen explain female females healthy controls immune response immune responses independent independent of Infectious disease Laboratory lymphocyte male monocyte patients patients with COVID-19 Peripheral blood Physiology Prevalence proportion proportions respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 patient severity of COVID-19 Sex sex-specific specificity subset T cell Viral [DOI] 10.1042/BSR20202074 PMC 바로가기 [Article Type] Immunology & Inflammation
COVID 19-Induced Smell and Taste Impairments: Putative Impact on PhysiologyPhysiology Published on 2021-01-262022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Anosmia asymptomatic phase Central nervous system consequence country COVID COVID 19 COVID 19 patient Feeding behavior Impact impairment involved main mechanism management nasal Pathways physiological functions Physiology physiopathology receptor reported Smell Symptom Taste the patient virus [DOI] 10.3389/fphys.2020.625110 PMC 바로가기 [Article Type] Physiology
Crystal Structure and Pathophysiological Role of the Pneumococcal Nucleoside-binding Protein PnrA폐렴구균 뉴클레오사이드 결합 단백질 PnrA의 결정 구조 및 병리생리학적 역할Article Published on 2021-01-222024-08-24 Journal: J Mater Chem B [Category] 폐렴구균 감염증, [키워드] crystal structure nucleoside Physiology pneumococci transporter virulence
Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19COVID-19 통제를 위한 영양소에서 Nrf2, TRPA1 및 TRPV1 간의 잠재적 상호작용Review Published on 2021-01-012022-09-11 Journal: International archives of allergy and immunology [Category] 바이오마커, [키워드] activated Activation Broccoli clinical evidence Compound Control cough Cough challenge COVID-19 COVID-19 symptoms desensitization diarrhea discharge induce Inflammation ingredient Loss of Smell loss of smell and taste morbidity nasal nasal obstruction Nrf2 nuclear nutrient organs oxygen Pain Physiology Potential Pungent foods reactive oxygen species reactive oxygen specy receptor receptor potential reduce Regulation responsible severity suggested symptom severity symptoms of COVID-19 Taste Therapeutic strategies TRAP TRAP-1. TRAP1 TRPA1 TRPV1 up-regulated vomiting [DOI] 10.1159/000514204 PMC 바로가기 [Article Type] Review
Prone Positioning in Moderate to Severe Acute Respiratory Distress Syndrome Due to COVID-19: A Cohort Study and Analysis of PhysiologyOriginal Research Published on 2020-12-312022-10-29 Journal: Journal of Intensive Care Medicine [Category] COVID-19, MERS, [키워드] 95% CI acute respiratory distress acute respiratory distress syndrome addition ARDS baseline benefit changes in cohort study competing conditions Control control group Coronavirus disease 2019 COVID-19 criteria determine Effect evaluate fractional inspired oxygen hospital IMPROVE In-hospital death Intervention Intubated linear mechanically ventilated mechanically ventilated patient moderate Mortality New York City outcome outcomes oxygen pandemic parameters participant patients treated patients with ARDS patients with moderate physiological Physiology positioning Primary outcome Probability prone Prone position prone positioning reduced respiratory Respiratory failure risk secondary severe acute respiratory syndrome coronavirus 2 severe ARDS significantly syndrome The United States therapeutic option Treatment Weighting were excluded were used [DOI] 10.1177/0885066620980399 PMC 바로가기 [Article Type] Original Research
Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19Physiology Published on 2020-12-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] angiotensin autoimmune condition autophagy cascade cause cellular clinical complication coagulative coronary syndrome COVID-19 cytokine dependent on Disseminated intravascular coagulation distress dysregulation Effect effector cells elicited facilitate fibrinolytic growth factor highlight Hyperactivation hypoxia immune immune responses include increases in induce Inflammatory literature mechanism mechanisms mediators of inflammation Midkine myocarditis NETs, autophagy neutrophil infiltration Neutrophils New coronavirus Occurrence organs pathogen clearance pathological condition pathophysiological physiological Physiology Potential pro-inflammatory cytokines pulmonary fibrosis receptor Renin replicate response role SARS-CoV2 SARS-CoV2 infection severe cases severe pneumonia similarity System target tissues Thromboembolism tissue tissue damage virus entry [DOI] 10.3389/fphys.2020.616552 PMC 바로가기 [Article Type] Physiology
COVID-19: A Challenge to Physiology of AgingPhysiology Published on 2020-12-032022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] age aging anti-aging drugs appear approach calory caused CFR challenge condition conditions country COVID-19 COVID-19 case COVID-19 pandemic death decrease Diseases doubling drug Endothelium Epidemic epidemiologists Fatality rate form growth increase Intervention involved manifestation measure molecular mechanism molecular target Mortality neurological pandemic pathophysiological Patient physical physical activity physiological balances physiological response Physiology prevalent promote public health reduced resource robust signaling pathway signaling pathways significantly stages theories total mortality Treatment [DOI] 10.3389/fphys.2020.584248 PMC 바로가기 [Article Type] Physiology
Computational simulation to assess patient safety of uncompensated COVID-19 two-patient ventilator sharing using the Pulse Physiology EngineResearch Article Published on 2020-11-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] adaptor addition approach arterial oxygen tension breathing circuit Characteristics clinical condition clinically Clinicians complicate correlated COVID-19 COVID-19 pandemic creating end-tidal Engine equipment estimate expected Factor finding Health less limb lung Lung compliance lung mechanics medical resource Metrics outcome oxygen saturation oxygenation index oxyhemoglobin saturation parameter parameters Patient patient safety patient selection patients physiological Physiology provide raise Region risk splitting Support to define Treatment Ventilated Ventilation ventilator was used while [DOI] 10.1371/journal.pone.0242532 PMC 바로가기 [Article Type] Research Article