Case-Control Study of Individuals with Discrepant Nucleocapsid and Spike Protein SARS-CoV-2 IgG Results뉴클레오캡시드 및 스파이크 단백질 SARS-CoV-2 IgG 결과가 일치하지 않는 개인에 대한 사례 대조 연구Article Published on 2021-07-062022-09-11 Journal: Clinical Chemistry [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] 1080 Abbott advent Analysis anti-Nucleocapsid IgG Anti-S1 anti-Spike IgG Antibody detection assays CDC chart clinical information Cohort Concordance conducted COVID-19 described determine discrepant results Euroimmun implication individual Infection Interpretation less over Patient plasma sample plasma samples positive probable COVID-19 receiver operating characteristics Result retrospective SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG sensitivity serologic assay serology specificity spike submitted subset Surveillance tested threshold vaccination were used [DOI] 10.1093/clinchem/hvab045 PMC 바로가기 [Article Type] Article
Development and validation of a quantitative, non-invasive, highly sensitive and specific, electrochemical assay for anti-SARS-CoV-2 IgG antibodies in saliva타액에서 항 -SARS-COV-2 IgG 항체에 대한 정량적, 비 침습적, 매우 민감하고 구체적인 전기 화학 분석의 개발 및 검증Research Article Published on 2021-07-012022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] analyzed anti-SARS-CoV-2 IgG antibody Antibody test antibody tests Antigen blinded CLIA complex COVID-19 development ELISA kit enzyme False positive False positives followed by gel IgG antibodies IgG antibody individual individuals Laboratory limit of detection linearity Non-invasive Patient peroxidase plasma plasma sample plasma samples platform Polymer positive Quantitative Saliva SARS-CoV-2 SARS-CoV-2 antibody test specificity Standard deviation Symptom the mean the patient vaccination was obtained was performed [DOI] 10.1371/journal.pone.0251342 PMC 바로가기 [Article Type] Research Article
Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors나노플라즈몬 바이오센서를 활용한 SARS-CoV-2 감염의 RNA/스파이크 단백질/IgG/IgM 바이오마커의 다중 및 고처리량 무표지 검출Article Published on 2021-06-292022-09-11 Journal: Analytical Chemistry [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody applied approach Biomarker biosensor calculated caused Characteristics clinician coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic detect detection diagnostic diagnostic test diagnostic tests diagnostics disease effective Genes healthy individual healthy individuals IgG and IgM IgM antibodies Infection limit of detection Mann-Whitney nonparametric MOST multiplex Negative predictive value nonparametric test P -value Patient plasma sample plasma samples platform Positive predictive value positive rate Predictive value Prevalence progression proof proof of concept provide receiving respiratory responses SARS-CoV-2 screening test sensitivity severe acute respiratory syndrome Coronavirus severity specificity Spike protein Stage subunits Treatment true negative true positive rate unmet need Viral viral nucleic acid virus [DOI] 10.1021/acs.analchem.0c05300 PMC 바로가기 [Article Type] Article
Evaluation of the IgG antibody response to SARS CoV-2 infection and performance of a lateral flow immunoassay: cross-sectional and longitudinal analysis over 11 monthsSARS CoV-2 감염에 대한 IgG 항체 반응 평가 및 측방 유동 면역 분석의 성능: 11개월에 걸친 횡단면 및 종단 분석Article Published on 2021-06-292022-09-11 Journal: BMJ Open [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] Abbott Abbott SARS-CoV-2 IgG anti-SARS-CoV-2 antibody antibody levels Blood Blood donations Cohort collected comprehensive analysis convalescent plasma COVID-19 cross-sectional detectable diagnostic Diagnostic microbiology diagnostics Donor Elecsy Elecsys ELISA Euroimmun evaluate healthcare worker humoral immune response IgG IgG antibodies IgG antibody immunoassay immunoassays individual individuals Infection Ireland Laboratory lateral flow lateral flow immunoassay LFIA Longevity longitudinal analysis minimum molecular molecular diagnostics outcome pandemic Performance metrics persistence plasma sample plasma samples positive Post-infection post-symptom onset Rapid Rapid test Research Roche SARS CoV-2 SARS-CoV-2 antibody SARS-CoV-2 ELISA SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 spike protein sensitivity Sensitivity and specificity serological specificity Spike protein Test [DOI] 10.1136/bmjopen-2020-048142 PMC 바로가기 [Article Type] Article
Seroprevalence of Anti-SARS-CoV-2 Antibodies in Blood Donors from Nuevo Leon State, Mexico, during 2020: A Retrospective Cross-Sectional Evaluation2020 년 멕시코 누에 보 레온 스테이트 (Nuevo Leon State)의 헌혈자에서 항 -SARS-COV-2 항체의 혈청 유병률 : 후 향적 단면 평가Brief Report Published on 2021-06-242022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott Abbott SARS-CoV-2 IgG analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Architect Asymptomatic case asymptomatic infection Blood blood donor Blood donors changes in Chemiluminescent assay collected COVID-19 distribution donors epidemiological epidemiological surveillance female identify investigated majority males Mexico pandemic plasma sample plasma samples Prevalence progression protocols reactive recorded resulting SARS-CoV-2 SARS-CoV-2 pandemic serological survey seropositive Seroprevalence Spread state Surveillance the SARS-CoV-2 Weekly [DOI] 10.3390/v13071225 PMC 바로가기 [Article Type] Brief Report
Immune age and biological age as determinants of vaccine responsiveness among elderly populations: the Human Immunomics Initiative research program노인 인구의 백신 반응성을 결정하는 면역 연령 및 생물학적 연령: 인간 면역학 이니셔티브 연구 프로그램New Study Published on 2021-06-122022-09-10 Journal: European Journal of Epidemiology [Category] MERS, 바이오마커, [키워드] absence age Aging-related diseases approach biochemical biological age Biomarker Biomarkers Cohort cohorts COVID-19 determinant determine Effectiveness Efficacy ENhance exploration genetics geographical location Health status Human Human Vaccines humoral humoral immune response hypothese hypotheses idea immune Immune aging immune responses Immunity immunomics Infectious disease Infectious diseases Influenza influenza- initiative joint methodological Non-communicable disease non-communicable diseases offered Older participant pathway pertussis vaccine pertussis vaccines phenotype phenotypic data plasma sample plasma samples pneumococcal population-based cohort populations predictability predictor Program prospective cohort Public public health representing Research SAME AS School selected subsequent Vaccine vaccine response vaccine responses Vaccine responsiveness [DOI] 10.1007/s10654-021-00767-z PMC 바로가기 [Article Type] New Study
Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patientCases with a Message Published on 2021-06-102022-10-29 Journal: Rheumatology International [Category] COVID-19, MERS, SARS, [키워드] abdomen abdominal pain Analysis analyzed caused characterized Course COVID-19 COVID-19 infection CT scan Cytokine analysis Cytokines described disease Disease progression Effect elevated female Heterotopic ossification Hospital admission Infection manifested Mild Myositis ossificans Pain Patient performed plasma sample pro-inflammatory cytokine radiological progression recovering from COVID-19 significantly Soft tissue syndrome the patient tissue area tomography warmth [DOI] 10.1007/s00296-021-04911-6 PMC 바로가기 [Article Type] Cases with a Message
Low level SARS-CoV-2 RNA detected in plasma samples from a cohort of Nigerians: Implications for blood transfusion나이지리아 인 코호트로부터 혈장 샘플에서 검출 된 저수준 SARS-COV-2 RNA : 혈액 수혈에 대한 시사점Research Article Published on 2021-06-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection average age BGI Blood blood plasma blood sample Blood samples Blood Transfusion Chain Reaction Cohort Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Ct value detection diagnose diagnostic EDTA Effects False negative false negatives False positive fluorescent global pandemic implication in viral individual male median medium MINI nasal swab nasopharyngeal Oropharyngeal PCR plasma plasma sample polymerase chain polymerase chain reaction positive Qiagen real time Real-time PCR recorded respiratory RNA RT-PCR RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 test SARS-CoV-2 viral RNA Sensitivity and specificity severe acute respiratory syndrome Coronavirus specificity sputum study participant Study participants Swab swab sample tested Transport transport medium triggered venepuncture Viral Viral RNA viral RNA Mini Kit VTM was done was obtained [DOI] 10.1371/journal.pone.0252611 PMC 바로가기 [Article Type] Research Article
Plasma Markers of Disrupted Gut Permeability in Severe COVID-19 Patients중증 COVID-19 환자의 장 투과성 장애를 나타내는 혈장 표지자Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] applied approach Bacterial Blood cause clinical implications contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Crosstalk disease severity Diseases disrupt Disrupted Disruption exacerbate functions fungal glycome glycomics Gut gut barrier integrity highlight immune activation implicated Inflammation Injury intestinal investigated Lipidomics lung Lung injury marker metabolome metabolomics microbe microbes microbial microbial translocation mortality rate negative controls permeability Plasma marker plasma markers plasma metabolome plasma sample plasma samples positive positive feedback resulting SARS-CoV-2 severe coronavirus disease severe COVID-19 severity systemic inflammation Systems biology tight junction translocation zonulin [DOI] 10.3389/fimmu.2021.686240 PMC 바로가기 [Article Type] Immunology
Antibody Responses and the Effects of Clinical Drugs in COVID-19 PatientsCOVID-19 환자에서 항체 반응과 임상 약물의 효과Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] Affiliated Hospital Anti-RBD IgG anti-viral drug Anti-viral drugs antibody Antibody titer Arbidol Bilirubin Chloroquine clinical Clinical treatment collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CRP demonstrated diagnosed direct bilirubin disease drug Effect ELISA Epidemic epidemic disease glucocorticoid Host humoral Humoral response humoral responses hydroxybutyrate dehydrogenase IgG and IgM IgM antibodies Infection Inflammatory responses laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Lopinavir Lopinavir/ritonavir lymphocyte Patient peripheral lymphocyte plasma plasma sample plasma samples Protein Protein subunit RBD Receptor binding domain reduced response Ritonavir SARS-CoV-2 SARS-CoV-2 nucleic acid serum severe symptom severe symptoms significantly Specific specific antibodies specific antibody Spike protein subunit suggested Sun Yat-sen therapy total bilirubin university while α-Hydroxybutyrate dehydrogenase [DOI] 10.3389/fimmu.2021.580989 PMC 바로가기 [Article Type] Immunology