In Silico Study of Coumarins and Quinolines Derivatives as Potent Inhibitors of SARS-CoV-2 Main ProteaseChemistry Published on 2021-02-082022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] absence acute respiratory syndrome addition binding binding affinity Candidates caused China complex Compound coronavirus coumarin Coumarins deaths derivative effective therapy Efficiency enzyme evaluate expected high affinity highest affinity inhibitor inhibitors inhibitory less Ligand M pro maturation molecular molecular docking molecular dynamics pandemic Pfizer potent protease provide quinolines SARS-CoV-2 the disease the SARS-CoV-2 these compound Toxicity Treatment Wuhan [DOI] 10.3389/fchem.2020.595097 PMC 바로가기 [Article Type] Chemistry
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19구아노신 뉴클레오티드 유사체의 이중 전구약물인 AT-527은 시험관 내 SARS-CoV-2의 강력한 억제제이자 COVID-19 치료를 위한 유망한 경구 항바이러스제입니다Antiviral Agents Published on 2021-02-082022-08-31 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Administered Antiviral approved AT-511 AT-527 AT-9010 causative agent cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective epithelial cells FDA Guanosine half-life HCoV HCoV-OC43 hepatitis C hepatitis C virus Huh-7 cells human airway epithelial human coronavirus human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide OC43 oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir Replication replication of SARS-CoV-2 required respiratory Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19Antiviral Agents Published on 2021-02-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] acute respiratory syndrome Administered Antiviral approved AT-511 AT-527 AT-9010 cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective FDA Guanosine HCoV-OC43 hepatitis C virus Huh-7 cells human airway epithelial human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir replication of SARS-CoV-2 required Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19Antiviral Agents Published on 2021-02-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, SARS, [키워드] acute respiratory syndrome Administered Antiviral approved AT-511 AT-527 AT-9010 cells Concentration coronavirus Coronavirus-2 Coronaviruses COVID-19 cytotoxicity distribution dose effective FDA Guanosine HCoV-OC43 hepatitis C virus Huh-7 cells human airway epithelial human lung in vitro activity incubated inhibit lung metabolite nasal epithelial cell nucleotide oral pharmacokinetic pharmacokinetic data potent predict prodrug Remdesivir replication of SARS-CoV-2 required Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown subject subjects tissue treat Treatment triphosphate [DOI] 10.1128/AAC.02479-20 PMC 바로가기 [Article Type] Antiviral Agents
Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral ActivityArticle Published on 2021-02-012022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] accelerated acetylated activity anti-infection antioxidant antiviral activity calculated Cell correlation COVID-19 COVID-19 infection CPE Cytopathic effect cytotoxicity Effect explain Final Glycation HDL HDL-C high-density high-density lipoproteins (HDL) higher risk Human hypertension impair in vitro inhibition activity LDL lipoprotein Low-density lipoprotein low-density lipoproteins Mortality Native paraoxonase patients with diabete phagocytosis potent pro-inflammatory progression Protein reported SARS-CoV-2 selective serum Vero E6 viability while [DOI] 10.3390/antiox10020209 PMC 바로가기 [Article Type] Article
Potent mouse monoclonal antibodies that block SARS-CoV-2 infectionSARS-CoV-2 감염을 차단하는 강력한 마우스 단일 클론 항체Accelerated Communication Published on 2021-01-302022-09-10 Journal: The Journal of Biological Chemistry [Category] 유전자 메커니즘, 진단, [키워드] ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed anti-SARS-CoV-2 antibodies caused cells chimeric clinical setting convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19, Coronavirus disease 2019 Critical disease disease control ELISA ELISA, enzyme-linked immunosorbent assay ERGIC, endoplasmic reticulum–Golgi intermediate compartment global pandemic Hope IF, immunofluorescence immunoassay immunoassays immunofluorescence immunoprecipitation IP, immunoprecipitatio Molecular biology Molecular pathology monoclonal antibodies monoclonal antibody mouse monoclonal antibody neutralize Neutralizing activity neutralizing antibody outbreak potent produced Prophylaxis RBD, receptor-binding domain Region Research respiratory robust RSV, respiratory syncytial virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SDS, sodium dodecyl sulfate severe acute respiratory syndrome Coronavirus spike the antibody therapy variable regions WB, western blotting western blotting Winter [DOI] 10.1016/j.jbc.2021.100346 PMC 바로가기 [Article Type] Accelerated Communication
Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing ResponsesArticle Published on 2021-01-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antigenicity appear approach boost COVID-19 pandemic COVID-19 vaccine disease displaying dose ectodomain effective elicited ELISA geometric highlight immunization immunized mimicking morphology negative-stain electron microscopy neutralization neutralization titer Neutralizing activity neutralizing antibody newcastle disease virus Particle potent prefusion conformation prefusion-stabilized spike prime immunization response S-2P stabilization SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-neutralizing antibody significantly higher spike Vaccine virus Virus-like particle virus-like particles VLP Week [DOI] 10.3390/vaccines9020073 PMC 바로가기 [Article Type] Article
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies상징적인 SARS-CoV-1 항체의 성숙을 통한 강력한 SARS-CoV-2 결합 및 중화Article Published on 2021-01-012022-09-11 Journal: mAbs [Category] 변종, 진단, [키워드] 2003 SARS 80R antibody antibody engineering antibody maturation binding clone coronavirus coronavirus spike protein CR3014 CR3022 Cryo-electron microscopy Crystallography disease domain effort emerging viruses Epitopes Infection m396 mAb mAbs maturation monoclonal antibodies monoclonal antibody neutralization neutralize open outbreak parental phage display potent PROTECT SARS-CoV-1 SARS-CoV-2 specificity Spike protein structural studies. the SARS-CoV-2 variant variants viruses X-ray crystallography [DOI] 10.1080/19420862.2021.1922134 PMC 바로가기 [Article Type] Article
The SARS-Cov-2 Proliferation Blocked by a Novel and Potent Main Protease Inhibitor via Computer-aided Drug DesignOriginal Article Published on 2021-01-012022-10-30 Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19, [키워드] ADME ADMET Analysis approval Area binding affinity binding energy complex Compound computation coronavirus disease COVID-19 DCCM drug drug design effort In-vitro inhibit Ligand MD simulation MM-PBSA molecular docking Molecular dynamic novel outcome pandemic PCA positive control potent Prevalence protease protease inhibitors residue selected stability surface treat Virtual screening was used were used [DOI] 10.22037/ijpr.2021.114846.15061 PMC 바로가기 [Article Type] Original Article
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2Report Published on 2020-12-182022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affinity Anti-spike antibody Bacteria cells complex Concentration coronavirus COVID-19 pandemic group half-maximal inhibitory concentration identify immunization inactive indicated inhibit intravenously mammalian cell mechanisms microbe multivalent nanobodies nanobody neutralization neutralization potency neutralize Neutralizing nonoverlapping epitope potent Prevent produced proteomics RBD Receptor binding domain SARS-CoV-2 Science screened selected Spike protein stability synthetic nanobody the RBD the spike protein therapeutic viral infection yeast [DOI] 10.1126/science.abe4747 PMC 바로가기 [Article Type] Report