potential therapeutic target
[용어속성] Term
Viral pandemic preparedness: A pluripotent stem cell-based machine-learning platform for simulating SARS-CoV-2 infection to enable drug discovery and repurposing
바이러스 대유행 대비: SARS-CoV-2 감염을 시뮬레이션하여 약물 발견 및 용도 변경을 지원하는 만능 줄기 세포 기반 기계 학습 플랫폼
Article
[키워드] alveolar
Antiviral
approved drug
Cell
clinical study
clinical testing
clinical trial
Combination
computer simulations
creating
DeepNEU
distribution
drug
drug combination
drug combinations
Drug discovery
drug discovery and repurposing
Drug repurposing
effective
evaluate
global pandemic
identify
imperative
IMPROVE
infected with SARS-CoV-2
lab
lab data
lung cell
machine-learning
Outbreaks
pandemic
pandemic preparedness
performed
platform
potential therapeutic target
potential therapeutic targets
repurposing
Research
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 virus
the SARS-CoV-2 virus
therapeutic option
therapeutic target
unsupervised learning
unsupervised learning.
Vaccine
Vaccine development
Viral
viral genome
[DOI] 10.1002/sctm.20-0181 PMC 바로가기 [Article Type] Article
[DOI] 10.1002/sctm.20-0181 PMC 바로가기 [Article Type] Article
Pathogenesis of Multiple Organ Injury in COVID-19 and Potential Therapeutic Strategies
Physiology
[키워드] 2019-nCoV
ACE2
Activation
acute respiratory disease
Ang II
binding
biological activity
bowel
Brain
cell type
claimed
confirmed cases
coronavirus
coronavirus disease
COVID-19
COVID-19 pathogenesis
described
downregulation
downstream
Effect
effective therapy
enzyme
Express
expressed
Fatality rate
feature
global effort
highlight
host cell
human cell
identify
infect
infected individual
Injury
kidney
life-threatening
liver
lung
Multiple
multiple organ dysfunction
Novel coronavirus
other organs
pandemic
pathophysiology
Potential
potential therapeutic target
Protective
Protein
RAAS
reduced
Respiratory disease
resulting
Safe
SARS-CoV-2
SARS-CoV-2 biology
SARS-COV-2 infection
Strategy
Structure
susceptible
syndrome
systemic inflammation
the disease
therapy
tissues
viral infection
[DOI] 10.3389/fphys.2021.593223 PMC 바로가기 [Article Type] Physiology
[DOI] 10.3389/fphys.2021.593223 PMC 바로가기 [Article Type] Physiology
Can GPR4 Be a Potential Therapeutic Target for COVID-19?
Medicine
[키워드] acute respiratory syndrome
asymptomatic infection
Can
cause
caused
Cell
clinical manifestation
coronavirus
coronavirus disease 19
COVID-19
death
Diffuse alveolar damage
edema
Endothelial cell
expressed
G protein-coupled receptor
global pandemic
GPR4
hyper-inflammatory response
Inflammation
inflammatory cell infiltration
inflammatory conditions
Injury
Interaction
leukocyte infiltration
lung
mild respiratory
mitigate
other organ
other organs
pathological findings
pathophysiology
Potential
potential therapeutic target
pro-inflammatory
Pulmonary edema
regulate
Respiratory failure
SARS-CoV-2
SARS-COV-2 infection
severe pneumonia
target
Thromboembolism
tissue
tissue injury
Treatment
Vascular
vascular endothelial cell
vascular permeability
vessel
with COVID-19
[DOI] 10.3389/fmed.2020.626796 PMC 바로가기 [Article Type] Medicine
[DOI] 10.3389/fmed.2020.626796 PMC 바로가기 [Article Type] Medicine
17β‐estradiol reduces SARS‐CoV‐2 infection in vitro
17β-estradiol은 시험관 내 SARS-CoV-2 감염을 감소시킵니다
Original Research
[키워드] 17β‐estradiol
ACE2
affected
affecting
approach
Cell
cell line
coronavirus
COVID‐19
COVID‐19
cycle
demonstrated
Economy
Effect
ERα
ERβ
Estrogen
estrogen receptors
evaluate
explain
expressed
female
Gender
Gene Expression
GPER1
host cells
human cell line
human cell lines
in vitro
in vitro model
Infection
involved
men
modulation
opens
organism
potential therapeutic target
Protein
public health
receptor
reduce
reducing
reduction in
SARS‐CoV‐2
SARS‐CoV‐2 infection
SARS‐CoV‐2
sex hormone
Sex hormones
Society
specific treatment
steroid
steroid hormone
These data
TMPRSS2
treated
Treatment
Vaccine
Vero E6
VERO E6 cells
Viral
Viral load
virus infection
women
Wuhan
Wuhan, China
[DOI] 10.14814/phy2.14707 PMC 바로가기 [Article Type] Original Research
[DOI] 10.14814/phy2.14707 PMC 바로가기 [Article Type] Original Research
Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse Lung
Immunology
[키워드] ACE2
ACE2 sequence
acute lung injury
Analysis
analyzed
approaches
Bayesian
Body weight loss
BXD family
caused
chromosome
core
Coronaviruses
defined
disease
disease risk
disease severity
Dissection
enzyme
epithelial cells
expression
expression level
function
gene co-expression network
gene product
H1N1
Hierarchical
Host
host response
identify
include
Infection
Influenza
influenza A virus
lung
Lung infection
Lung injury
MAPK
membrane-bound
MERS-CoV
mice
modulate
molecular
morbidity and mortality
mouse
mRNA level
network analysis
outcome
parental
participated
potential therapeutic target
primary human airway
Protein
pulmonary
quantified
respiratory diseases
RNA-Seq
SARS-CoV
SARS-CoV-2
Sepsis
severity
signaling pathways
significantly
strain
TNF
transcript
Transcriptome
variant
viral infection
viral infections
Viral load
viremia network
weight loss
WGCNA
[DOI] 10.3389/fimmu.2020.607314 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.607314 PMC 바로가기 [Article Type] Immunology
Higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients might be correlated with inhibition of Type I IFN signaling
경증 COVID-19 환자에서 단핵구 주화성 단백질 1의 더 높은 발현은 I형 IFN 신호의 억제와 상관관계가 있을 수 있습니다
Research
[키워드] acute respiratory syndrome
characterized
chemokine
Chemokine receptor
chemokine receptors
chemokines
chemotactic
China
city
coronavirus
coronavirus disease
Coronavirus disease 2019
correlated
correlation
COVID-19
COVID-19 case
COVID-19 cases
COVID-19 patient
COVID-19 patients
demonstrated
detect
elevated
enzyme
enzyme-linked immunosorbent
enzyme-linked immunosorbent assay
epidemiological
evaluate
expressed
expression
expression level
expression levels
finding
Host immune response
IFN
IFN signaling
immunopathological
Infection
interferon
IRF3
MCP-1
mechanism
Mild
mild case
mild cases
mild COVID-19 patient
mild COVID-19 patients
monocyte
Patient
polymerase chain
polymerase chain reaction
potential therapeutic target
potential therapeutic targets
Protein
provide
real-time polymerase chain reaction
receptor
Regulatory
respiratory
Result
Serum level
serum levels
severe acute respiratory syndrome Coronavirus
severe coronavirus disease
shown
signaling molecule
signaling molecules
significant negative correlation
Type
was measured
[DOI] 10.1186/s12985-020-01478-9 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/s12985-020-01478-9 PMC 바로가기 [Article Type] Research
Molecular Mechanisms of Vascular Damage During Lung Injury
폐 손상 중 혈관 손상의 분자 메커니즘
Review
[키워드] acute lung injury
acute respiratory distress
acute respiratory distress syndrome
ADRS
alveolar epithelium
ARDS
association
behavioral risk factors
change
contribute
COVID-19
Cytokines
damage
disease
disease risk
Disruption
DNA
DNA methylation
endothelial activation
Enzyme inhibitor
Enzyme inhibitors
Epigenetic
epigenetics
epithelial
Epithelial barrier
evaluate
experimental model
experimental models
explained
Factor
focus
Genetic
genetic factors
Genetic polymorphism
genetic polymorphisms
Genetic predisposition
high mortality rate
histone
Histone acetylation, DNA methylation
Hospitalization
humans
increased vascular permeability
Inflammation
Inflammatory response
Injury
intensive care
lung endothelial
Lung injury
mechanism
Modification
molecular mechanism
molecular mechanisms
Mortality
occur
offer
Pathogenesis
phenotypic
potential therapeutic target
Prevent
pro-inflammatory cytokines
promote
Research
respiratory distress
Respiratory distress syndrome
Risk factors
susceptibility
syndrome
systemic and local
treat
variety
Vascular damage
Vascular endothelium
vascular permeability
[DOI] 10.1007/978-3-030-68748-9_6 PMC 바로가기 [Article Type] Review
[DOI] 10.1007/978-3-030-68748-9_6 PMC 바로가기 [Article Type] Review
Understanding the andromeda strain – The role of cytokine release, coagulopathy and antithrombin III in SARS-CoV2 critical illness
안드로메다 균주 이해 - SARS-CoV2 중병에서 사이토카인 방출, 응고병증 및 안티트롬빈 III의 역할
Review
[키워드] Antithrombin
antithrombin III
autopsy analysis
benefit
China
circulating
Coagulation
Coagulopathy
coronavirus
COVID-19
COVID-19 infections
Critical
Critical illness
cytokine release
Europe
globe
hematology
heparin
Heparin resistance
mediator
Microthrombosis
Mortality
Multiple
observational studies
observational study
organizations
pandemic
Part
pathology
pathophysiology
Patient
performed
physician
potential therapeutic target
Prognostic marker
Prophylactic
prothrombotic
reduction
reductions
reported
SARS-CoV
SARS-CoV critical illness
SARS-CoV2
severe COVID-19 infections
Society
temper
thrombosis
thrombotic
thrombotic complication
Thrombotic complications
understanding
[DOI] 10.1016/j.blre.2020.100731 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.blre.2020.100731 PMC 바로가기 [Article Type] Review