Time trend prediction and spatial-temporal analysis of multidrug-resistant tuberculosis in Guizhou Province, China, during 2014-20202014-2020년 중국 구이저우성 다제내성결핵의 시간동향 예측 및 공간-시간적 분석Article Published on 2022-06-072022-09-11 Journal: BMC Infectious Diseases [Category] 치료제, [키워드] access to treatment Admission Affect affected Analysis analyzed autocorrelation average calculated case finding Case series case sery caused China Cluster COVID-19 COVID-19 pandemic disease distribution effort Epidemic exhibited heterogeneity information lifted MDR-TB moving average multidrug-resistant tuberculosis past prediction ranged resource rising SARIMA model seasonality Spatial−temporal analysis. System time Treatment trough Tuberculosis [DOI] 10.1186/s12879-022-07499-9 PMC 바로가기 [Article Type] Article
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies Research Published on 2022-06-072022-10-05 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] approach association competing Computational drug conformation ENhance epigenomic epigenomics eQTL expression expressions extension gene expression level genomic help increase independent Informed loci median Model outperform predict prediction Quantitative Region target gene traits transcriptome-wide variants [DOI] 10.1038/s41467-022-30956-7 [Article Type] Research
Estimating COVID-19 Hospitalizations in the United States With Surveillance Data Using a Bayesian Hierarchical Model: Modeling StudyArticle Published on 2022-06-022023-07-08 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), [키워드] Bayesian COVID-19 COVID-NET data estimation extrapolation framework Hierarchical hospital Hospitalization Model modeling monitoring novel prediction Rate SARS-CoV-2 Surveillance United States [DOI] 10.2196/34296 PMC 바로가기
Integration of omics data to generate and analyse COVID-19 specific genome-scale metabolic modelsomics 데이터를 통합하여 COVID-19 특정 게놈 규모 대사 모델 생성 및 분석Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] 바이오마커, 유전자 메커니즘, 치료제, [키워드] addressed analyses Analysis Antiviral applied approach cholesterol cholesterol metabolism code Combination complex Context-specific models COVID-19 COVID-19 patients dataset datasets disease down-regulated downregulated downregulation enrichment FIVE generate genome-scale metabolic models host response include indicated Infection integration MEM metabolic Metabolic enrichment analysis metabolic pathway metabolic pathways metabolism Model Model extraction methods. observation observations predicted prediction preserved Previous studies previous study produced provided retinol separated targets transcriptomic Variability Vitamin D3 [DOI] 10.1016/j.compbiomed.2022.105428 PMC 바로가기 [Article Type] Article
Risk Prediction for Acute Kidney Injury in Patients Hospitalized With COVID-19Research article Published on 2022-06-012022-10-05 Journal: Kidney Medicine [Category] 바이오마커, [키워드] 95% CI Acute kidney injury acute respiratory syndrome added age AKI baseline changes in coding Cohort cohort study cohorts comorbid condition conditions coronavirus coronavirus disease COVID-19 creatinine criteria D-dimer levels defined delta variant develop exposure ferritin Final High-sensitivity C-reactive protein hospital hospitalized patient Improving inflammatory biomarkers KDIGO Kidney injury laboratory data limitation longitudinal measure median Model model validation objective participant Patient patients patients hospitalized polymerase chain positive Potential predict prediction Predictive Predictive model rationale Result setting Vaccine validation cohort virus variants with COVID-19 [DOI] 10.1016/j.xkme.2022.100463 [Article Type] Research article
HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infectionCOVID-19 및 SARS-CoV-2 감염에서 HLA 변이 및 항원 제시Review Published on 2022-06-012022-09-11 Journal: Current opinion in immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Affect affinity Antigen Antigen presentation association COVID-19 Critical Genotype HLA HLA molecules HLA variation human leukocyte antigen immune evasion immune response immune responses Immunity immunogenic leukocyte mechanism mutant Mutation natural immunity outcome peptide peptides prediction Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins shown Spike protein strain T cells T-cell Response T-cell responses the Spike understanding Vaccine development variant Variation viral strains [DOI] 10.1016/j.coi.2022.102178 PMC 바로가기 [Article Type] Review
A New Approach to Drug Repurposing with Two-Stage Prediction, Machine Learning, and Unsupervised Clustering of Gene Expression2 단계 예측, 기계 학습 및 유전자 발현의 감독되지 않은 클러스터링으로 약물 용도에 대한 새로운 접근 방식Article Published on 2022-06-012022-08-31 Journal: Omics : a journal of integrative biology [Category] MERS, 신약개발, 유전자 메커니즘, [키워드] Acetate affected alvocidib analyzed approach approximation big data bioinformatics BMS-387032 candidate Candidates characteristic clinical trial clinical trials Cluster Clusters Compound conditions Consistency Control COVID-19 pandemic Critical dermatomyositis develop dimension disease Diseases drug Drug development Drug discovery Drug efficacy Drug repurposing drug research and OMICS effective enrichment enrichment analysis examined expected expression pattern expression patterns followed by for inclusion function functions Gene Expression gene set enrichment analysis Health human diseases identify Inclusion Inclusion body inclusion body myositis Infectious disease Infectious diseases Innovation Intervention machine learning Manifold mitoxantrone myositis New offer pathway phorbol phorbol-12-myristate-13-acetate polymyositis prediction premise Probability projection repurposing Research reversed Reversibility targets Uniform variety vorinostat [DOI] 10.1089/omi.2022.0026 PMC 바로가기 [Article Type] Article
Vulture-Based AdaBoost-Feedforward Neural Frame Work for COVID-19 Prediction and Severity Analysis SystemVulture-Based AdaBoost-Feedforward Neural Frame Work for COVID-19 예측 및 심각도 분석 시스템Article Published on 2022-06-012022-09-11 Journal: Interdisciplinary sciences, computational life sci [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy affected Affected part tracking Analysis chest X-ray Chest X-ray image Chest X-ray images complexity COVID COVID-19 COVID-19 disease COVID-19 severity death deep learning develop disease early stage error rate Feature extraction human body humans identify initial involved machine learning mechanism Neural offer prediction reduce required Research researcher risk Segmentation severity Severity analysis. spread of COVID-19 System virus Vulture work X-ray [DOI] 10.1007/s12539-022-00505-3 PMC 바로가기 [Article Type] Article
Neurological manifestations in COVID-19 patients and their application in predicting fatal disease: A retrospective cohort studyArticle Published on 2022-06-012023-07-06 Journal: Journal of microbiology, immunology, and infection [Category] COVID19(2023년), [키워드] Central nervous system Fatal outcome prediction SARS-CoV-2 [DOI] 10.1016/j.jmii.2021.07.010 PMC 바로가기
Understanding Dynamics of Pandemic Models to Support Predictions of COVID-19 Transmission: Parameter Sensitivity Analysis of SIR-Type ModelsCOVID-19 전파 예측을 지원하기 위한 팬데믹 모델의 역학 이해: SIR 유형 모델의 매개변수 민감도 분석Article Published on 2022-06-012022-09-11 Journal: Ieee Journal of Biomedical and Health Informatics [Category] COVID19(2023년), SARS, 변종, [키워드] applied approach average basic reproduction number Community conjunction COVID-19 COVID-19 transmission Dynamics effort Epidemic failure Global Sensitivity Analysis greater infected case infected cases influence information initial Interaction Isolation Local measure Measures Model pandemic parameter populations predict predictability prediction Predictive Prevent Prevention and control reached SEIR sensitivities sensitivity summation Transmission understanding variable variant [DOI] 10.1109/JBHI.2022.3168825 PMC 바로가기 [Article Type] Article