Description of a One-Year Succession of Variants of Interest and Concern of SARS-CoV-2 in Venezuela베네수엘라에서 SARS-CoV-2에 대한 관심 및 우려의 변종에 대한 1년 연속 설명Article Published on 2022-06-242022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha VOC antibody Antibody-mediated neutralization circulating Complete concern correlation country COVID-19 Delta Delta VOC description dissemination Frequency Gamma Genome sequencing genomic interest Lambda less Lineage lineages low frequency MONITOR Mutation mutations neutralization New coronavirus omicron predominant Rapid screening responsible SARS-CoV-2 sequenced Transmissibility variant variants variants of concern Venezuela VoC VOCs VOI VOIs WHO [DOI] 10.3390/v14071378 PMC 바로가기 [Article Type] Article
Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants렘데시비르와 GS-441524는 델타, 오미크론 및 기타 신종 SARS-CoV-2 변이체에 대해 항바이러스 활성을 유지한다Article Published on 2022-06-212022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 50% effective concentration activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents Antiviral treatment change circulating Combination conserved coronavirus COVID-19 Delta disease severity Effectiveness ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of exhibited fold Genetic variation GS-441524 highlight isolate Neutralizing antibodies Nsp12 nucleoside omicron Omicron variants Other P323L pandemic parent nucleoside potency predominant prevalent RdRP RDV reduction remained Remdesivir retained RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sequences severe acute respiratory syndrome Coronavirus Spread Substitution Support susceptible sustained tested the SARS-CoV-2 Treatment Vaccine variant variants Variation Veklury Viral transmission virus viruses WA1 [DOI] 10.1128/aac.00222-22 PMC 바로가기 [Article Type] Article
TNF-α + CD4 + T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodiesTNF-α + CD4 + T 세포는 COVID-19 외래 환자에서 SARS-CoV-2 특이적 T 세포 반응을 지배하고 내구성 항체와 관련이 있습니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody boost CD4 Cell Cohort coronavirus Coronavirus 2019 COVID-19 COVID-19 outpatient Cytokines enrolled feature IFNγ IL-21 Immunity Infection interferon gamma longitudinal maintenance mRNA mRNA vaccination NCT04331899 Necrosis Neutralizing antibodies neutralizing antibody percentage Post-infection predominant producing respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell response T cells Tfh the SARS-CoV-2 These data TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha [DOI] 10.1016/j.xcrm.2022.100640 PMC 바로가기 [Article Type] Article
Phase 1/2 clinical trial of COVID-19 vaccine in Japanese participants: A report of interim findings일본 참가자를 대상으로 한 코로나19 백신 임상 1/2상: 중간 결과 보고Clinical Trial Published on 2022-06-152022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Adults Antigen CD4+ T-cell cellular immunity clinical clinical trial comparable convalescent serum COVID-19 COVID-19 vaccine evaluate evaluated healthy IFN-γ IgG IL-2 IL-4 immune reaction immunogenicity initiated interim analysis Intramuscular injection Japanese Mild neutralizing antibody Participants patients peptide phase Placebo placebo-controlled predominant Protein Randomized reactogenicity recombinant Recombinant protein regimen regimens response robust Safe Safety Serious Adverse Event Spike protein the vaccine Trial vaccination Vaccine [DOI] 10.1016/j.vaccine.2022.04.054 PMC 바로가기 [Article Type] Clinical Trial
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccineesCOVID-19 mRNA 백신에 있는 Omicron BA.1 및 BA.2 중화 항체의 해부학Article Published on 2022-06-132022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered antibody BNT162b2 BNT162b2 mRNA vaccine class conserved COVID-19 COVID-19 pandemic cross-neutralize cross-neutralizing antibodies cross-neutralizing antibody cross-protection Donor Effect elicited epitope Epitopes Evidence germlines IGHV1-58 IGHV1-69 IGHV2-5 mitigate molecular molecular basis mRNA mRNA vaccine NAb NAbs neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody not neutralize NTD omicron other coronaviruses predominant question RBD Receptor binding domain recognize Region S protein SARS-CoV-1 SARS-CoV-1 virus SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccines seronegative seropositive Spike protein tested the S protein the SARS-CoV-2 vaccination Vaccine design vaccinee Vaccines variants variety virus Wuhan [DOI] 10.1038/s41467-022-31115-8 PMC 바로가기 [Article Type] Article
Sequential Appearance and Isolation of a SARS-CoV-2 Recombinant between Two Major SARS-CoV-2 Variants in a Chronically Infected Immunocompromised Patient만성 감염 면역저하 환자에서 두 가지 주요 SARS-CoV-2 변이체 간의 SARS-CoV-2 재조합체의 순차적인 출현 및 분리Article Published on 2022-06-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Alpha variant Analysis analyzed appearance backbone chronic infection Combination combinations concurrent infection Coronaviruses Follow-up genetic recombination Genome genomes genomic Genomic surveillance humans Immunosuppression infecting Infection initial lymphoma Major mechanism mutant Mutation Next-generation sequencing parental Patient PCR predominant recombinant Recombination reported RNA viruses SARS-CoV-2 SARS-CoV-2 variants Seven spike gene Surveillance the patient variant variants virus viruses was obtained [DOI] 10.3390/v14061266 PMC 바로가기 [Article Type] Article
Protection and Waning of Natural and Hybrid Immunity to SARS-CoV-2SARS-CoV-2에 대한 자연 및 하이브리드 면역의 보호 및 약화Article Published on 2022-06-092022-09-11 Journal: The New England Journal of Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted B.1.617.2 BNT162b2 BNT162b2 vaccine confounding factor confounding factors coronavirus Coronavirus 2019 Course database dose elapsed hybrid Immunity infected with SARS-CoV-2 Infection less Ministry of Health natural natural immunity Poisson regression predominant protection provide provided rates of infection receipt recent Reinfection risk SARS-CoV-2 SARS-COV-2 infection second dose second dose of vaccine severe acute respiratory syndrome Coronavirus shown single dose uninfected vaccination Vaccine variant [DOI] 10.1056/NEJMoa2118946 PMC 바로가기 [Article Type] Article
Assessment of antiphospholipid antibodies profiles based on severity of COVID-19 pneumoniaArticle Published on 2022-06-092022-11-15 Journal: The Pan African Medical Journal [Category] 진단, [키워드] antibodies antibody Anticoagulant anticoagulation Antiphospholipid APL assessment association clinical impact conducted coronavirus disease COVID-19 COVID-19 group COVID-19 patient COVID-19 patients Critical Critically ill ELISA enzyme-linked immunosorbent event Factor Frequency highest hospitalized patient ICU IgA IgM intensive care involved lupus anticoagulant mechanism no significant difference non-ICU Patient patients Pneumonia positive predominant profile profiles Prophylactic Retrospective study severe complication severity of COVID-19 tested thrombosis thrombotic Thrombotic events thrombotic risk was tested [DOI] 10.11604/pamj.2022.42.110.33020 PMC 바로가기
SARS-CoV-2 Delta variant isolates from vaccinated individualsSARS-CoV-2 Delta 변이체는 예방접종을 받은 개인에서 분리됩니다.Article Published on 2022-06-042022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 변종, [키워드] addition Affect circulating Cluster collected conformational change COVID-19 cytosolic Delta Delta B.1.617.2 delta variant Disruption genetic diversity Genome sequencing Genomic analysis hydrophobic immune evasion induce isolate isolates Lineage Mutation mutations Non-synonymous mutation Nsp15 Nsps ORF1 ORF1b ORF7a ORF8 Oxford Nanopore MinION polar position positive sample predominant premature stop codon Protein SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 virus SARS-CoV-2 viruses side chain Spike protein the spike protein transmembrane protein Transmissibility Transport vaccinated individual vaccinated individuals Vaccine variant variant of concern virus was performed Whole genome sequencing [DOI] 10.1186/s12864-022-08652-z PMC 바로가기 [Article Type] Article
Vaccine efficacy against severe COVID-19 in relation to delta variant (B.1.617.2) and time since second dose in patients in Scotland (REACT-SCOT): a case-control study델타 변이체(B.1.617.2) 및 스코틀랜드 환자의 2차 접종 이후 경과 시간(REACT-SCOT)과 관련된 중증 COVID-19에 대한 백신 효능: 사례-대조군 연구Article Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 95% CI age Alpha Analysis ascertainment bias B.1.1.7 B.1.617.2 booster doses Case-control case-control study ChAdOx1 ChAdOx1 vaccine classification coded community health Control controls COVID-19 Critical care database death declined decrease defined delta variant diagnosed dose Efficacy expected first positive Follow-up hospitalisation include index measure Moderna mRNA mRNA vaccine mRNA vaccines not limited outcome Patient Pfizer predominant presenting primary care primary outcome measure Protective replaced replacement report reported reversed risk SARS-CoV-2 variant Scottish second dose selected Severe case severe cases severe COVID-19 severe disease severity Sex study period suggested Support transmission rate transmission rates vaccination Vaccine vaccine efficacy Vaccines variant [DOI] 10.1016/S2213-2600(22)00045-5 PMC 바로가기 [Article Type] Article