Animal and translational models of SARS-CoV-2 infection and COVID-19 Reviews Published on 2020-08-202022-10-05 Journal: Mucosal Immunology [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] animal animal model Cell chronic disease Chronic diseases clinical trial Community competing COVID-19 Critical defined described develop disease disease manifestation drugs effective feature global pandemic Head-to-head comparison Human lack patient cohort primary human cell Primary infection SARS-COV-2 infection tissue tissues to define translational [DOI] 10.1038/s41385-020-00340-z [Article Type] Reviews
SARS-CoV-2 infection protects against rechallenge in rhesus macaquesResearch Article Published on 2020-08-142022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome anamnestic Bronchoalveolar lavage cellular immune responses coronavirus coronavirus disease COVID-19 Critical Evidence humans humoral immune response Immunity implication induce Infection infection with SARS-CoV-2 initial log Lower respiratory tract macaque Median viral load nasal mucosa pandemic pathologic Primary infection PROTECT protective immunity public health question reductions in Reinfection rhesus rhesus macaque robust SARS-CoV-2 SARS-COV-2 infection Science sick suggested tested Vaccine viral clearance Viral load Viral pneumonia virus [DOI] 10.1126/science.abc4776 PMC 바로가기 [Article Type] Research Article
Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaquesArticle Published on 2020-07-072022-11-01 Journal: Cell Research [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus candidate vaccine cause characterized demonstrated edema evaluate Genome-wide association studies Infection infiltration interstitial pneumonia lung lung; lymphocyte Mild monocyte mortality rate neutralizing antibody non-human primate model Novel coronavirus observation occurred oropharyngeal swab oropharyngeal swabs outbreak platform Pneumonia post infection Primary infection PROTECT provide public health reflected Replication respiratory tract respiratory tract tissues rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 RNA severe cases susceptible viral infection Viral RNA virus Whole genome amplification World Health Organization [DOI] 10.1038/s41422-020-0364-z PMC 바로가기 [Article Type] Article
Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaquesReport Published on 2020-07-022022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome caused cellular immunity changes characterized clinical manifestation coronavirus Coronavirus disease 2019 COVID-19 detectable dissemination early recovery gastrointestinal tracts global pandemic histopathological humoral immune responses Infection initial interstitial pneumonia neutralizing antibody Patient Primary infection PROTECT Reinfection rhesus rhesus macaque rhesus macaques risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain subsequent viral disease [DOI] 10.1126/science.abc5343 PMC 바로가기 [Article Type] Report
Characterization of antiviral T cell responses during primary and secondary challenge of laboratory cats with feline infectious peritonitis virus (FIPV)Research Article Published on 2019-05-222022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] acute infection adaptive Antiviral Antiviral T cell responses Blood Cell-mediated immunity cellular immunity characterization Clinical outcome demonstrated develop difference disease Disease progression early phase early stage experimental group Feline infectious peritonitis Feline infectious peritonitis virus healthy Host Immunity implicated Infection Interaction Laboratory later phase Lymph node lymphocyte outcome pathogen pathogenic Predictive Primary infection progression proliferation provided Result robust SPF subset suggested survived T cell T cell depletion T cell response T cell subset tested viral antigens virus WBC White blood cell [DOI] 10.1186/s12917-019-1909-6 PMC 바로가기 [Article Type] Research Article
Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibodyResearch Article Published on 2017-08-172022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] absence accompanied acute respiratory disease antibody Asymptomatic case asymptomatic infection Betacoronavirus Clinical signs complement confirmed case Contact tracing deaths develop dose-dependent elicited enhanced Human implication increase in individual Infection Inflammation Inflammatory response inoculated intranasal Lung disease Lung inflammation lung lobe MERS-CoV Middle East Mild naïve Neutralizing activity neutralizing antibody Neutralizing antibody response Neutralizing antibody titer New non-neutralizing antibody occur perivascular inflammation Primary infection PROTECT Protein Proteins Pulmonary infection pulmonary inflammation recruitment Reinfection reported respiratory syndrome coronavirus risk serum subsequent transfer Viral antigen viral challenge Viral protein Viral RNA waned while zoonotic [DOI] 10.1371/journal.ppat.1006565 PMC 바로가기 [Article Type] Research Article
Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014Expedited Published on 2016-01-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] acute respiratory illness age Case–control study Control Diabetes Mellitus Direct disease dromedary camels environmental exposure Factor healthcare heart disease Human illness illness onset medical condition MERS-CoV Middle East Middle East respiratory syndrome Coronavirus multivariable analysis Primary infection reported respiratory respiratory syndrome coronavirus Risk factors Saudi Arabia Sex smoking Transmission viruses zoonosis [DOI] 10.3201/eid2201.151340 PMC 바로가기 [Article Type] Expedited
Characterization of the immune response in ganglia after primary simian varicella virus infectionArticle Published on 2015-12-162023-05-31 Journal: Journal of Neurovirology [Category] Fulltext, 두창, 수두, 홍역, [키워드] immune response Primary infection sensory ganglia Simian varicella virus Varicella-Zoster Virus [DOI] 10.1007/s13365-015-0408-1 PMC 바로가기 [Article Type] Article
[Vaccines against varicella-zoster virus (VZV)]수두-대상포진 바이러스(VZV)에 대한 백신Article Published on 2015-06-012023-05-31 Journal: Enferm Infecc Microbiol Clin [Category] 대상포진, 두창, 수두, 홍역, [키워드] herpes zoster Infección primaria Primary infection Vaccine vacunas Virus varicela Virus varicella. [DOI] 10.1016/j.eimc.2015.05.005
Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigsResearch Article Published on 2015-05-062022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] antibody clinical Contact Day demonstrated disease effective Endemic epidemic diarrhea evaluate homologous immune response Infection Infectious virus information initial naïve PCR PCR-negative PCR-positive PEDV pig positive Primary infection protective immunity Re-infection repeated RNA S1 and S2 selected seroconverted Transmission Vaccine virus virus transmission was determined [DOI] 10.1186/s13567-015-0180-5 PMC 바로가기 [Article Type] Research Article