Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases만성 염증성 폐 질환에 대한 잠재적 진단 및 예후 바이오마커로서의 안지오텐신 전환 효소 2(ACE2)Review Published on 2021-07-092022-09-10 Journal: Genes [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 acting airway airways aldosterone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approved Asthma Biomarker blood pressure characterized chronic chronic inflammatory lung diseases chronic obstructive chronic obstructive pulmonary disease complete recovery control mechanisms coronavirus coronavirus 2019 disease COVID-19 diagnostic disease early diagnosis electrolyte balance enzyme expressed hypertension immune response Inflammation Inflammatory inflammatory lung disease lack liver lung Lung diseases Lungs majority mechanism obstructive pulmonary disease open pathophysiological pathophysiological mechanism pathophysiology Perspective Potential problems protective role pulmonary disease pulmonary diseases pulmonary hypertension RAAS recent finding recent findings Regulation renal systems renin-angiotensin-aldosterone system (RAAS) shown therapeutic Therapeutic approach [DOI] 10.3390/genes12071054 PMC 바로가기 [Article Type] Review
DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and FranceMS의 DMTS 및 COVID -19 심각도 : 이탈리아와 프랑스의 풀링 된 분석Multicenter Study Published on 2021-07-072022-09-10 Journal: Annals of Clinical and Translational Neurology [Category] meta-analysis, 진단, [키워드] Analysis association baseline characteristics evaluated France increased risk indicated interferon Italy large cohort multivariate model Patient protective role risk severity significantly Support therapy [DOI] 10.1002/acn3.51408 PMC 바로가기 [Article Type] Multicenter Study
DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and FranceMulticenter Study Published on 2021-07-072022-10-27 Journal: Annals of Clinical and Translational Neurology [Category] COVID-19, MERS, [키워드] Analysis association baseline characteristics evaluated France increased risk indicated interferon Italy large cohort multivariate model Patient protective role risk severity significantly Support therapy [DOI] 10.1002/acn3.51408 PMC 바로가기 [Article Type] Multicenter Study
Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19혈장의 다중 생물 프로파일 링Research Paper Published on 2021-07-062022-09-10 Journal: Theranostics [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adults alteration Analysis Anti-inflammatory antioxidant AUC blood sample Blood samples children children with COVID-19 Cohort Combination conducted Coronaviral coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 demonstrated develop enrolled exhibiting experiment expression finding healthy children Hospital admission Hospital admissions identify immune Inference inhibited less machine learning mannitol mechanism metabolite metabolites metabolomic profiling methylmalonic acid Mild symptom mild symptoms molecular molecules outpatients Pathogenesis pathogenesis of COVID-19 performed plasma potential therapeutic agent potential therapeutic agents pro-inflammatory factors Protective protective effect Protective effects protective role Protein proteomic provided Replication reveal severe symptom statistical analyses suppressed therapeutic agents up-regulated [DOI] 10.7150/thno.61832 PMC 바로가기 [Article Type] Research Paper
Inverse association between hypertension treatment and COVID-19 prevalence in JapanResearch article Published on 2021-07-012022-10-05 Journal: International Journal of Infectious Diseases [Category] SARS, 유전자 메커니즘, 치료법, [키워드] age Analysis analyzed Angiotensin-converting enzyme Angiotensin-converting enzyme II antagonistically association circulatory system classification Coronavirus disease 2019 correlation COVID-19 Critical database demonstrated disease disorders entry of SARS-CoV-2 enzyme enzyme II group homologous hypertension hypertensive inhibitor inverse Japan Japanese Local Lungs nitric oxide objective Patient patients treated Prevalence problem proportion protective role Result revision SARS-CoV-2 SARS-COV-2 infection significant negative correlation Spread spread of COVID-19 Treatment [DOI] 10.1016/j.ijid.2021.05.071 [Article Type] Research article
The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infectionsSARS-CoV-2 감염의 잠재적인 치료 표적으로서 레닌-안지오텐신 시스템 및 특히 안지오텐신 전환 효소 2Article Published on 2021-07-012022-09-11 Journal: Naunyn-Schmiedeberg's Archives of Pharmacology [Category] SARS, 치료제, [키워드] ACE-2 angiotensin angiotensin-converting enzyme 2 Cardiovascular function caused complex mechanism complex mechanisms country COVID-19 COVID-19 infection COVID-19 pandemic deaths entry receptor explanation hypothese modulation occurred pharmacological potential therapeutic target prevented preventive measure preventive measures protective role Protein RAS Regulation Renin renin-angiotensin system respiratory tract SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection Spread therapeutic intervention Therapeutic strategies vaccination Variation variations viral infection virus Wuhan Wuhan, China [DOI] 10.1007/s00210-021-02108-z PMC 바로가기 [Article Type] Article
Babaodan controls excessive immune responses and may represent a cytokine-targeted agent suitable for COVID-19 treatmentBabaodan은 과도한 면역 반응을 제어하고 COVID-19 치료에 적합한 사이토카인 표적 제제를 나타낼 수 있습니다Article Published on 2021-07-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 치료법, [키워드] Activation adapter anti-cytokine storm anti-inflammatory activity approach Babaodan Bacterial Bacterial infection cellular Chinese contribute Control COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokines demonstrated determine evaluated excessive immune response IL-6 immune responses immunomodulatory in vivo increased survival indicated Inflammation inhibited Macrophage macrophages MAPK MAPK signaling mechanism mice molecular mouse model MYD88 NF-κB occur Occurrence overproduction Pathways Pneumonia pro-inflammatory cytokine pro-inflammatory cytokines protective role Protein recruitment reduction in responsible resulting reveal robust SARS-COV-2 infection Seven severe COVID-19 severely ill COVID-19 patients significantly TCM therapy TLR TLR2 TLR3 TLRs Traditional Chinese medicine transcriptomic treating COVID-19 Treatment TRIF viruses was used [DOI] 10.1016/j.biopha.2021.111586 PMC 바로가기 [Article Type] Article
Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severitySARS-CoV-2에 감염된 햄스터 폐 조직의 정량적 단백질체학은 질병 발병기전 및 중증도에 영향을 미치는 숙주 인자를 나타냅니다Article Published on 2021-07-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] SARS, 유전자 메커니즘, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alveolar damage Analysis carried clinical parameter Clinical parameters coagulation cascade complement convalescence coronavirus COVID-19 COVID-19 patient COVID-19 patients DAD differential expression differentially expressed differentially expressed proteins Diffuse alveolar damage effort enriched pathways evaluate expression Factor Ferroptosis groups hamster hamsters histopathological Host in vivo infected with SARS-CoV-2 involved isolates Local lung Lung function Lung pathology lung proteome lung tissue lung tissues mass spectrometry Mesocricetus Orbitrap Pathogenesis pathological change pathophysiological Pathway analysis platelet activation Post-infection progression protective role Protein proteomic proteomics Pulmonary Surfactant Quantitative reported resolved SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2-infected hamster SARS-CoV-2-infected hamsters severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity SFTPB SFTPD significantly surfactant Syrian golden hamster Syrian Golden hamsters the disease tissue sample tissue samples [DOI] 10.1096/fj.202100431R PMC 바로가기 [Article Type] Article
Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative안전하고 효과적인 SARS -COV -2 서브 유닛 백신 개발을위한 주요 고려 사항 : 펩티드 기반 백신 대안Review Published on 2021-06-272022-09-01 Journal: Advanced Science [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] angiotensin‐converting enzyme 2 antibody‐dependent enhancement Antigen antigens B‐cell clinical symptom conserved COVID‐19 critical binding residues deleted development developmental disorder Economy effective effective vaccine Effective vaccines Epitopes exhibit focus genetic material global health Health immune response immune responses immunogenic immunopathological Infection mechanisms mutant Neutralizing Neutralizing antibodies nonstructural protein peptide peptide vaccine Peptide vaccines Protective protective role Protein Proteins Receptor binding domain Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 similarities similarity Spike protein T‐cell type‐I interferons Vaccine vaccine antigen Vaccines Viral Viral protein Viral proteins virus [DOI] 10.1002/advs.202100985 PMC 바로가기 [Article Type] Review
Impact of COVID-19 on older adults and role of long-term care facilities during early stages of epidemic in ItalyArticle Published on 2021-06-152022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] addition Care coronavirus correlation COVID-19 COVID-19 incidence COVID-19 outbreak COVID-19 related mortality death dysfunction early stage Effect Epidemic Epidemiology explain facility first stage Geriatrics greater growth handling health system Impact Italy Long Mortality Older older adult outbreak overall mortality pandemic promoted protective role public health Quantitative Region regions SARS-CoV-2 Spread term the epidemic viral infection [DOI] 10.1038/s41598-021-91992-9 PMC 바로가기 [Article Type] Article