Coordinated innate and T-cell immune responses in mild COVID-19 patients from household contacts of COVID-19 cases during the first pandemic wave첫 번째 대유행 기간 동안 COVID-19 사례의 가정 접촉에서 경미한 COVID-19 환자의 조정된 타고난 및 T 세포 면역 반응Article Published on 2022-07-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] absence Alpha anti-N antibodies anti-RBD antibody B-cell cell-mediated response Concordance Contact COVID-19 COVID-19 case COVID-19 cases Cycle threshold value cytokine detectable early immune response early immune responses ELISA enrolled evaluated Factor Follow-up greater high accuracy household household contact household contacts IFN-α IFN-γ IL-1ra IL-1β IL-9 immune responses immunofluorescence Immunopathogenesis indirect immunofluorescence individual innate response interferon interferon-alpha Interferon-alpha (IFN-α) Interferon-gamma Interferon-gamma (IFN-γ) release assay (IGRA) IP-10 MCP-1 membrane mild COVID-19 patient MIP-1β moderate Nasopharyngeal swab Neutralizing antibodies nucleocapsid pandemic peptide peptide pools plasma plasma samples positive positive swab Proteins RANTES RBD reported response returned RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 swab screened Seroconversion serological serological response significant negative correlation Spike protein stimulated subject Surveillance Swab Swab test swabs T-cell T-cell immune response T-cell Response T-cell specific virus Whole blood [DOI] 10.3389/fimmu.2022.920227 PMC 바로가기 [Article Type] Article
Longitudinal Serum Proteome Characterization of COVID-19 Patients With Different Severities Revealed Potential Therapeutic Strategies다양한 중증도를 가진 COVID-19 환자의 세로 혈청 프로테옴 특성이 잠재적인 치료 전략을 드러냄Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation alteration Analysis Asymptomatic asymptomatic patient asymptomatic patients caused characterization cholesterol cholesterol metabolism Cluster cluster analysis coagulation cascade collected complement Complement activation control group control groups COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Disease progression dysregulation effective expand global healthcare heterogeneity Hierarchical hierarchical cluster analysis immune response individuals involved longitudinal metabolism Mild moderate Moderate COVID-19 moderate COVID-19 patients molecular Non-COVID-19 not recovered Pathogenesis pathophysiological Patient patients performed PLGLB1 Potential potential therapeutic target potential therapeutic targets progression Protein Proteins proteomic proteomics restored Revealed SARS-CoV-2 serum serum biomarker serum biomarkers Serum level serum sample serum samples severity Strategy symptomatic Treatment understanding [DOI] 10.3389/fimmu.2022.893943 PMC 바로가기 [Article Type] Article
Structure-selected RBM immunogens prime polyclonal memory responses that neutralize SARS-CoV-2 variants of concern구조 선택 RBM 면역원은 우려되는 SARS-CoV-2 변이체를 중화하는 다클론성 기억 반응을 일으킵니다.Article Published on 2022-07-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Affect Amino acid amino acid residue antibody Antibody Response B.1.351 B.1.617.2 booster C57BL/6 can be used conserved COVID-19 pandemic domain effort full-length full-length spike protein immunization immunogen immunogenic immunogens Immunoglobulin majority memory response mice neutralize Neutralizing Neutralizing antibodies neutralizing antibody Plasmid polyclonal Prevent Protein Proteins purified RBD RBM receptor-binding motif Recombinant spike protein resulting SARS-CoV-2 variant sera spike Spike protein Spike proteins the antibody response Transmission Vaccine variants variants of concern virus VoC VOCs vulnerability WA1 wildtype [DOI] 10.1371/journal.ppat.1010686 PMC 바로가기 [Article Type] Article
Smart Immunosensors for Point-of-Care Serological Tests Aimed at Assessing Natural or Vaccine-Induced SARS-CoV-2 Immunity자연 또는 백신 유도 SARS-CoV-2 면역 평가를 목표로 하는 현장 진료 혈청 검사를 위한 스마트 면역 센서Article Published on 2022-07-212022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] Accuracy acquisition Analysis antigens Assessing carried Clinical data COVID-19 diagnostic effective epidemiological data human serum immobilization Immunoglobulin immunoglobulins immunosensor Internet Internet of Things IoT-Wi-Fi IRCCS IRCCS Ospedale San Raffaele natural nucleocapsid point-of-care point-of-care testing Proteins protocol provided Quantitative SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 infected patients sensitivity serological test Serological tests signal SmaRT specificity specimen storage Test Viral Viral antigen were assessed [DOI] 10.3390/s22145463 PMC 바로가기 [Article Type] Article
Glycyrrhetinic acid: A potential drug for the treatment of COVID-19 cytokine stormGlycyrrhetinic acid : Covid-19 사이토 카인 폭풍의 치료를위한 잠재적 약물Article Published on 2022-07-202022-08-31 Journal: Phytomedicine : international journal of phytother [Category] 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] Analysis caused core genes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cytokine storm cytokine Cytokine storm database docking result effective ESR1 experiment experimental results Experimental verification experiments Glycyrrhetinic acid Health Human IL-17 IL6 immune in vitro in vivo Infection Inflammatory inhibit inhibitory effect Interaction Intervention KEGG Kyoto lack lipopolysaccharide MAPK3 mechanism molecular docking molecule network network pharmacology Ontology pathway pathway enrichment PPAR signaling PPARG PPI PPI network predict protein-protein interaction Proteins PTGS2 R language Research screened signaling pathway signaling pathways significantly target gene Target genes targets TNF TNF signaling treat Treatment triggered Venn diagram was performed [DOI] 10.1016/j.phymed.2022.154153 PMC 바로가기 [Article Type] Article
Molecular Characterization of Kunitz-Type Protease Inhibitors from Blister Beetles (Coleoptera, Meloidae)딱정벌레(딱정벌레목, 멜로과)의 쿠니츠형 프로테아제 억제제의 분자 특성화Article Published on 2022-07-152022-09-12 Journal: Biomolecules [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] active site acute lung injury Analysis Anticoagulant Beetle biochemical bioinformatics Blister blister beetle characterization characterized drug drugs example feature full-length increasingly inhibitor involved Kunitz-type protease inhibitors lesions mRNA natural nervous system organ Organisms pathology pathophysiology protease Protease inhibitor Protein protein modelling Proteins reported resource SARS-COV-2 infection sequence serine protease Side effect targets transcriptomic transcriptomic analysis transcriptomic analysis. translational validation widespread [DOI] 10.3390/biom12070988 PMC 바로가기 [Article Type] Article
Differences in endosomal Rab gene expression between positive and negative COVID-19 patientsCOVID-19 양성 및 음성 환자 간의 엔도솜 Rab 유전자 발현의 차이Article Published on 2022-07-152022-09-11 Journal: BMC Research Notes [Category] 유전자 메커니즘, [키워드] ACE2 analysed control group coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient difference endocytic Endocytic pathway epithelial etiologic agent expression Gene Expression groups host cell Infection internalization Mann Whitney U Test mRNA patients performed positive Proteins Rab Rab11b Rab5 Rab7 RNA RT-PCR SARS CoV SARS CoV-2 SARS CoV-2 infection significant difference significant differences significantly significantly increased Statistical tests Test viral entry virus [DOI] 10.1186/s13104-022-06144-7 PMC 바로가기 [Article Type] Article
Pre-Omicron Vaccine Breakthrough Infection Induces Superior Cross-Neutralization against SARS-CoV-2 Omicron BA.1 Compared to Infection AlonePre-Omicron 백신의 획기적인 감염은 단독 감염에 비해 SARS-CoV-2 Omicron BA.1에 대해 우수한 교차 중화를 유도합니다Article Published on 2022-07-122022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] antibody antibody levels Antibody Response Antibody responses B.1 boost Breakthrough infection comparable convalescent convalescent sera convalescent serum correlated COVID-19 patient cross-neutralization cross-neutralizing antibodies cross-neutralizing antibody Delta disease elicited evade form Gamma had no higher affinity highlight Immunity individuals induce infecting Infection Live virus Mild moderate disease N-terminal domain neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity NTD nucleocapsid omicron Omicron BA.1 Patient patients with moderate Protein Proteins raise RBD Receptor-binding domain remained retained SARS-CoV-2 SARS-CoV-2 variants sera spike Spike protein Spike proteins strain Strains Superior the disease the RBD the receptor-binding domain the Spike the spike protein Transmissibility vaccination Vaccine Variability variant variants variants of concern variants of concern (VOCs) virus-induced antibodies VoC VOCs [DOI] 10.3390/ijms23147675 PMC 바로가기 [Article Type] Article
Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by portable wireless graphene biosensor휴대용 무선 그래핀 바이오센서를 통한 타액 내 처리되지 않은 SARS-CoV-2 바이러스 및 그 변이체의 신속한 자가 테스트Article Published on 2022-07-122022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aptamer biosensor clinically Cognate Concentration coronavirus COVID-19 D614G detect determined by diagnostic DNA domain early phase environmental monitoring epidemiological epidemiologically field-effect transistor Graphene limit limit of detection LoQ MERS Middle East Middle East respiratory syndrome N protein N501Y nucleocapsid omicron pandemic plaque plaque-forming unit platform positive Precision Protein Proteins public health quantitation Rapid RBD Receptor-binding domain respiratory RT-PCR S protein Saliva saliva samples SARS-CoV-2 SARS-CoV-2 variant sensitivity sensor severe acute respiratory syndrome coronavirus 2 significantly lower specificity Spike protein statistically variant variants of concern viral particle Viral particles Viral proteins virus Y453F [DOI] 10.1073/pnas.2206521119 PMC 바로가기 [Article Type] Article
SARS-Arena: Sequence and Structure-Guided Selection of Conserved Peptides from SARS-related Coronaviruses for Novel Vaccine DevelopmentSARS-Arena: 새로운 백신 개발을 위한 SARS 관련 코로나바이러스에서 보존된 펩티드의 서열 및 구조 유도 선택Article Published on 2022-07-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] 3D structure affected against SARS-CoV agent Analysis approach can be used case study caused CD8 computational method Computational methods conserved contribute coronavirus COVID-19 disease cross-reactive database development envelope proteins help HLA HLA-Arena HLA-B7 Human human leukocyte antigen humoral Humoral response immune response less leukocyte mitigate MOST Multiple sequence alignment N protein Notebook novel nucleocapsid nucleocapsid protein pandemic peptide peptides pHLA scoring Practitioner practitioners Prevent Protein protein regions protein sequence protein sequence alignment protein sequences Proteins Region related viruses responsible SARS-CoV SARS-CoV viruses SARS-CoV-2 SARS-CoV-2 virus Selection selection pressure Sequence alignment Spike protein structural modeling. susceptible T-cell T-cells target the disease the N protein the SARS-CoV-2 virus the spike protein therapy Vaccine development Vaccines variants viral envelope protein viral strains viruses widespread [DOI] 10.3389/fimmu.2022.931155 PMC 바로가기 [Article Type] Article