Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirusArticle Published on 2018-04-042022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] addition anti-S antigen expression clinical trials control group effective ELISpot assay enhanced Final highlight IgG response immune response immunization immunized inactivated Infection interferon-γ Live virus lung membrane MERS-CoV mice Middle East Neutralizing activity nucleocapsid plaque-forming units protective immunity Protein Proteins public health threat reduced respiratory syndrome coronavirus Safe sera spike Spike protein structural proteins T-cell immunity tested the S protein transduced vaccination Vaccine Vaccines virus virus titers [DOI] 10.1038/s41426-018-0056-7 PMC 바로가기 [Article Type] Article
Estimating and modelling the transmissibility of Middle East Respiratory Syndrome CoronaVirus during the 2015 outbreak in the Republic of KoreaOriginal Article Published on 2017-08-172022-10-30 Journal: Influenza and Other Respiratory Viruses [Category] Coronavirus, MERS, [키워드] 95% confidence interval approaches average basic reproductive number Bayesian Contact demonstrated effective estimate identify Korean learning Mathematical modelling measure methodology middle Middle East Middle Eastern respiratory syndrome coronavirus objective outbreak overlapped Parameter estimation produced provide public health threat Quantitative ranged respiratory respiratory infection Result secondary case significantly higher South Korean outbreak Spread statistical statistical analysis susceptible Transmissibility Transmission Transmission dynamics Transmission model [DOI] 10.1111/irv.12467 PMC 바로가기 [Article Type] Original Article
Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike ProteinArticle Published on 2017-03-232022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] antibody approved Arabian Peninsula candidate Cellular immune response country cross-neutralizing demonstrated DNA DNA vaccine effective elicited expressing full-length highlight Host Human IgG IgG isotype immunization immunized immunogenicity induce investigated MERS-CoV MERS-CoV S protein mice pathogen Plasmid Prophylactic Protein Protein-based vaccines public health threat significant level Spread strain the Spike vaccination Vaccine vaccine candidate virus zoonotic [DOI] 10.1038/srep44875 PMC 바로가기 [Article Type] Article
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory VirusesResearch Article Published on 2013-07-252022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] approach both virus component conserved Critical dataset disease pathology effort epithelial cell event Factor feature Gene Host host response human lung identify Infection influence Influenza virus integration Interaction Intervention involved lung epithelial Metrics network Pandemics pathogen pathogenicity predict predicted proteome public health threat Regression model regulator Regulatory related respiratory respiratory virus SARS-CoV severe therapeutic target transcriptome dataset utility viral pathogenesis virus [DOI] 10.1371/journal.pone.0069374 PMC 바로가기 [Article Type] Research Article