Clinical efficacy and safety of high-flow nasal cannula (HFNC) in acute hypoxaemic patients with COVID-19: a protocol for a systematic review and meta-analysisCOVID-19를 가진 급성 저산소병 환자에서 고유 유량 코 캐뉼라 (HFNC)의 임상 효능 및 안전성 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-04-122022-08-31 Journal: BMJ Open [Category] meta-analysis, [키워드] Acute respiratory failure adult intensive & age and sex approach Caregivers clinical Clinical efficacy Cochrane Library Continuous data COVID-19 COVID-19 patient COVID-19 patients Critical Critical care data extraction determine develop disease severity Efficacy and safety eligibility criteria Ethical approval Ethics evaluate for inclusion HFNC High-flow nasal cannula hypoxaemic respiratory failure identify increased risk Infection transmission infections Intensive intensive care intensive care unit intubation mean difference meta-analyses Meta-analysis Mortality nasal nasal cannula outcome Participants Patient peer-reviewed performed Primary outcome PROSPERO protocol randomised controlled trial RCT RCTs registration number required respiratory Respiratory failure respiratory infections risk risk of bia risk ratio secondary outcome Secondary outcomes Subgroup analyses subgroup analysis systematic review the mean Treatment undergo Web of Science [DOI] 10.1136/bmjopen-2021-057743 PMC 바로가기 [Article Type] Article
Using information and communication technologies (ICTs) to solve the repressed demand for primary dental care in the Brazilian Unified Health System due to the COVID-19 pandemic: a randomized controlled study protocol nested with a before-and-after study including economic analysis정보 통신 기술(ICT)을 사용하여 COVID-19 전염병으로 인해 브라질 통합 의료 시스템에서 1차 치과 진료에 대한 억압된 수요 해결: 경제 분석을 포함한 전후 연구와 중첩된 무작위 통제 연구 프로토콜Article Published on 2022-04-072022-09-11 Journal: BMC Oral Health [Category] 임상, [키워드] All participant All participants alternative analyses Analysis benefit Care carried Child children clinical trial communication Coronavirus infections COVID-19 COVID-19 pandemic Dental unit develop Effect Effects enrolled feasible health system information Intervention national health system pandemic Perspective platform positive Potential potential benefits primary care Primary outcome Primary outcomes protocol randomization Randomized randomized controlled study RCT receive Registered repressed Research SUS System Teledentistry Telemonitoring Teleorientation. Trial trials [DOI] 10.1186/s12903-022-02101-9 PMC 바로가기 [Article Type] Article
Safety and efficacy of colchicine in COVID-19 patients: A systematic review and meta-analysis of randomized control trialsCOVID-19 환자에서 콜히친의 안전성과 효능: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-04-052022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI age all-cause mortality Analysis anti-inflammatory drug average average age C-reactive protein calculated carried clinical trial clinical trials Colchicine colchicine treatment COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity CRP level CRP levels Cytokine storm D-dimer level D-dimer levels database Diseases effective Efficacy evaluate FIVE Google Scholar Gout inhibiting Interleukins Invasion mean difference mechanical ventilation Meta-analysis no significant difference Odds ratio Odds ratios outcome outcomes P-value p-values Patient random-effects model Randomized randomized control trial RCT RCTs receiving reduce Safety safety profile searched significantly standard care statistically significant systematic review the cytokine storm total population treat Treatment trials [DOI] 10.1371/journal.pone.0266245 PMC 바로가기 [Article Type] Meta-Analysis
Effectiveness of an Internet-Based and Telephone-Assisted Training for Parents of 4-Year-Old Children With Disruptive Behavior: Implementation ResearchRandomized Controlled Trial Published on 2022-04-042022-10-05 Journal: Journal of Medical Internet Research [Category] 임상, [키워드] 95% CI adjusted age baseline Behavior behavior problems Characteristics checklist Child Behavior child mental health children clinics collected Complete covariates COVID-19 pandemic DASS-21 disruptive behavior early intervention Effectiveness Efficacy family Finnish Health home ICU implementation implication internet-assisted Intervention intervention group inventory lack linear mixed-effect model measure Measures Mental mental health no significant difference outcome parent parent training Parenting parents Preschool children problems Randomized controlled trial RCT recruited Registered repeated scale significant difference significantly situation SmaRT Southwest Finland Stress Scale study group total score training Treatment unmet need were measured were used [DOI] 10.2196/27900 PMC 바로가기 [Article Type] Randomized Controlled Trial
JAK inhibitors and COVID-19JAK 억제제 및 COVID-19Review Published on 2022-04-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] activated added Antiviral antiviral molecules Autoimmunity Baricitinib benefit clinical experience clinical trials coded concerning contributing to COVID-19 COVID-19 treatment cut-off cytokine Cytokine storm Cytokines differentiation Effect Effects Evolution family Graft hematologic hematologic neoplasms Human genome immune regulation immune response Immunosuppression immunosuppressive effect immunosuppressive effects indicated induce inhibited innate immune response interferons involved issue Jak JAK inhibitor jak inhibitors JAK1 JAK2 JAK3 JAKi janus Janus kinase kinases Meta-analysis moment Neoplasms nezulcitinib outcome pathogenic pathway Pathways patients treated patients with COVID-19 Phase 3 trials proliferation randomized clinical trial RCT reaction receptor reduce mortality rheumatic disease Rheumatic diseases risk reduction ruxolitinib SARS-COV-2 infection severe COVID-19 Side effect Signaling Significant Standard of care subsequent suggested survival the SARS-CoV-2 the WHO Therapies therapies, investigational. Tofacitinib transmembrane Treatment trials TYK2 Type I IFN type I interferons Viral viral replication virus clearance [DOI] 10.1136/jitc-2021-002838 PMC 바로가기 [Article Type] Review
Bias as a source of inconsistency in ivermectin trials for COVID-19: A systematic review. Ivermectin’s suggested benefits are mainly based on potentially biased resultsResearch article Published on 2022-04-012022-10-05 Journal: Journal of clinical epidemiology [Category] COVID19(2023년), SARS, 임상, [키워드] approach benefit Bia bias certainty of evidence changed clinically conducted Coronavirus infections COVID-19 Effect enrolled estimate Evidence IMPROVE individual Intervention Ivermectin mechanical ventilation methodological limitations moderate Mortality not reduce objective outcome pairwise meta-analysis patients with COVID-19 performed platform Prophylactic random-effect randomized trial RCT RCTs reported Research Result risk of bia Risk of bias SARS-CoV-2 searched sensitivity analysis Standard of care suggested symptom resolution systematic review Treatment Trial viral clearance [DOI] 10.1016/j.jclinepi.2021.12.018 [Article Type] Research article
Effectiveness of a nurse-led smartphone-based self-management programme for people with poorly controlled type 2 diabetes: A randomized controlled trialRandomized Controlled Trial Published on 2022-04-012023-07-08 Journal: Journal of advanced nursing [Category] COVID19(2023년), [키워드] mHealth Nurse-led Nursing poor glycaemic control RCT self-care Self-management type 2 diabetes [DOI] 10.1111/jan.15178 [Article Type] Randomized Controlled Trial
Monitoring COVID-19 vaccine use in Italian long term care centers: The GeroCovid VAX studyResearch article Published on 2022-04-012022-10-05 Journal: Vaccine [Category] COVID19(2023년), SARS, 임상, [키워드] anti-SARS-CoV-2 vaccination baseline characteristics Care changed COVID-19 infection COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine death Efficacy elderly event First wave frailty Frailty syndrome GeroCovid Vax high mortality rate include information initial Italian Italian study Long term care (LTC) LTC LTCs MONITOR monitoring nursing home Nursing homes (NH) Older outcomes Patient PROTECT protocol randomized clinical trial RCT RCTs routine care Safety Study protocol Vaccine [DOI] 10.1016/j.vaccine.2022.02.064 [Article Type] Research article
Efficacy and safety of current treatment interventions for patients with severe COVID-19 infection: A network meta-analysis of randomized controlled trials심각한 CovID-19 감염 환자에 대한 현재 치료 중재의 효능 및 안전성 : 무작위 대조 시험의 네트워크 메타 분석Article Published on 2022-04-012022-08-31 Journal: Journal of medical virology [Category] COVID19(2023년), meta-analysis, SARS, [키워드] 95% CI 95% confidence interval Abstract ACM all-cause mortality Auxora Azithromycin Characteristics Chinese controlled trials convalescent plasma coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection CP group database databases demonstrated dosage Efficacy Efficacy and safety English language Infection interferon beta Lopinavir Lopinavir-ritonavir medication medications Methylprednisolone Network meta-analysis Odds ratio Older participant Patient Placebo placebo group Randomized Randomized controlled trial Randomized controlled trials RCT RCTs Remdesivir Ritonavir Safety sarilumab searched severe coronavirus disease severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients significant decrease Standard of care TEAE TEAEs therapy Tocilizumab treatment intervention treatment-emergent adverse event treatment-emergent adverse events Trial α-lipoic acid [DOI] 10.1002/jmv.27512 PMC 바로가기 [Article Type] Article
Randomized Evaluation of Surgery in Elderly with Traumatic Acute SubDural Hematoma (RESET-ASDH trial): study protocol for a pragmatic randomized controlled trial with multicenter parallel group design외상성 급성 경막하 혈종이 있는 고령자의 수술에 대한 무작위 평가(RESET-ASDH 시험): 다기관 병렬 그룹 설계를 사용한 실용적인 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-03-292022-09-11 Journal: Trials [Category] 임상, [키워드] accompanied Acute subdural hematoma analyzed approval asked Belgium choice comatose Compliance Consent Consequences Conservative management conservative treatment COVID-19 crisis current discretion elderly enrolled Evidence expected foundation functional hematoma Hematoma evacuation Inclusion initial Injury intention-to-treat International midline shift multicenter Netherland Netherlands neurosurgery Neurotrauma outcome parallel group Patient patient recruitment Pragmatic primary endpoint Randomized Randomized controlled trial RCT recruited Study protocol SubDural Hematoma surgery surgical therapeutic trauma Traumatic brain injury treat Treatment Trial Variation was obtained [DOI] 10.1186/s13063-022-06184-1 PMC 바로가기 [Article Type] Article