Protracted viral shedding and viral load are associated with ICU mortality in Covid-19 patients with acute respiratory failureResearch Published on 2020-12-102022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress syndrome Acute respiratory failure age analyzed Antiviral treatment ARF Computed tomography conducted COVID-19 COVID-19 patient CT scan Deceased died discharge discharged fibrosis hospital discharge hospitalized patient ICU ICU patient independent risk factor intensive care unit Lung CT median time Mortality non-survivor Occurrence Patient performed Pneumonia polymerase chain reaction pulmonary fibrosis Respiratory failure respiratory sample respiratory tract Result retrospective risk RT-PCR SARS-CoV-2 significantly significantly higher significantly lower significantly shorter survivor university hospital viral clearance Viral load viral shedding with COVID-19 [DOI] 10.1186/s13613-020-00783-4 PMC 바로가기 [Article Type] Research
Molecular detection of SARS-CoV-2 using a reagent-free approachResearch Article Published on 2020-12-072022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] approach conditions Critical determine diagnostics effective false-negative group highlight include inhibitory initial Internal control investigated Laboratory methodology molecular reagent required respiratory sample risk RNA extraction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA sensitivity tested Transport media Treatment validation process various treatment Volume [DOI] 10.1371/journal.pone.0243266 PMC 바로가기 [Article Type] Research Article
Molecular and serological characterization of SARS-CoV-2 infection among COVID-19 patientsCOVID-19 환자 중 SARS-CoV-2 감염의 분자 및 혈청학적 특성Article Published on 2020-12-012022-09-11 Journal: Virology [Category] MERS, SARS, 진단, 치료기술, [키워드] addition Admission anal swab analyzed anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antibody Response Blood clearance clinical information Cohort collected COVID-19 COVID-19 patient COVID-19 patients demographic detectable different time point different time points disease severity Diseases Evidence immunoassays infection control intestine investigated levels of antibodies levels of antibody management median Mild moderate moderate symptoms Most patients multiple tissue multiple tissues nasal Novel coronavirus occurred Patient Patient management patients pharyngeal positive qRT-PCR reached respiratory respiratory sample Respiratory samples Respiratory system RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA scientific evidence sensitivity serological severity significant difference Specific specimen swabs Symptoms the disease the patient variable Viral viral kinetics Viral load Viral protein Viral proteins Viral RNA were measured [DOI] 10.1016/j.virol.2020.09.008 PMC 바로가기 [Article Type] Article
Long-Term SARS-CoV-2 Infection Associated with Viral Dissemination in Different Body Fluids Including Bile in Two Patients with Acute CholecystitisCase Report Published on 2020-11-232022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] assays bile biological sample Body body compartment body fluid Cholecystitis clinical manifestations collected contribute declined different time point digital PCR droplet digital PCR dropped highlight Including Infection nasopharyngeal Nasopharyngeal swab negativity onset of symptoms Patient patients plasma plasma sample provoke qRT-PCR quantification Rectal swabs respiratory sample RNA quantification RT-PCR SARS-CoV-2 SARS-CoV-2 positive patient SARS-CoV-2 RNA Symptom undetectable Urine Viral RNA [DOI] 10.3390/life10110302 PMC 바로가기 [Article Type] Case Report
Rapid SARS-CoV-2 antigen detection assay in comparison with real-time RT-PCR assay for laboratory diagnosis of COVID-19 in Thailand태국의 COVID-19 실험실 진단을 위한 실시간 RT-PCR 분석과 비교한 Rapid SARS-CoV-2 항원 검출 분석Comparative Study Published on 2020-11-132022-09-01 Journal: Virology Journal [Category] SARS, 진단, 치료기술, [키워드] 2019-nCoV 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Chain Reaction Characteristics comparable Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases cycle threshold diagnose diagnosis of COVID-19 evaluated False negative False positive FIVE gold gold standard individual individuals Infection Laboratory Laboratory test median nasopharyngeal negative test pandemic Patient patients PCR test performance polymerase chain reaction positive ranged Rapid Rapid antigen real-time RT-PCR real-time RT-PCR test respiratory respiratory sample Respiratory samples respiratory specimens Result RT-PCR RT-PCR assay SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 RNA Sensitivity and specificity severe acute respiratory syndrome Coronavirus specimen Spread test result test results Thailand throat swabs [DOI] 10.1186/s12985-020-01452-5 PMC 바로가기 [Article Type] Comparative Study
Nucleic acid amplification tests on respiratory samples for the diagnosis of coronavirus infections: a systematic review and meta-analysisSystematic Review Published on 2020-11-112022-11-01 Journal: Clinical microbiology and infection : the official [Category] COVID-19, SARS, [키워드] Accuracy acute respiratory syndrome acute respiratory tract infection affecting amplification assessment average can be used clinical samples Cochrane Library confidence coronavirus coronavirus disease Coronavirus infection Coronavirus infections COVID-19 defined diagnosed Diagnosis diagnostic eligibility eligible evaluate evaluated Grey high risk isothermal amplification Lower respiratory tract Meta-analysis meta-regression NAAT nucleic acid amplification nucleic acid amplification tests objective participant Patient PCR PCR assay PCR tests pooling Quality RdRP real-time RT-PCR reference reference standard Region reported respiratory sample Result RNA-dependent RNA polymerase RT-LAMP S gene SARS-CoV-2 sensitivity Sensitivity and specificity significantly higher significantly lower specificity systematic review transcriptase variable Web of Science [DOI] 10.1016/j.cmi.2020.11.002 PMC 바로가기 [Article Type] Systematic Review
Performance Evaluation of the SAMBA II SARS-CoV-2 Test for Point-of-Care Detection of SARS-CoV-2SARS-CoV-2의 현장 진단을 위한 SAMBA II SARS-CoV-2 테스트의 성능 평가Virology Published on 2020-10-132022-09-10 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis analytical sensitivity Cambridge Characteristics clinical coronavirus COVID-19 detection determined by Diagnosis effective evaluated Frame Genome implementation in silico infection control majority management Measures Microbiology nose/throat swab nucleic acid nucleic acid amplification nucleocapsid protein Open reading frame open reading frame 1ab ORF1ab Patient Patient management PCR assay performance POC point of care point-of-care tests positive primer Primers probe probes provided Public Public Health England RdRP RdRp gene real-time PCR assay Region respiratory respiratory sample Respiratory samples RNA SAMBA SAMBA II SAMBA II SARS-CoV-2 SAMBA II SARS-CoV-2 test SARS-CoV-2 SARS-CoV-2 test severe acute respiratory syndrome Coronavirus simple specificity Swab Test turnaround time turnaround times [DOI] 10.1128/JCM.01262-20 PMC 바로가기 [Article Type] Virology
Is recurrence possible in coronavirus disease 2019 (COVID-19)? Case series and systematic review of literature코로나바이러스 질병 2019(COVID-19)에서 재발이 가능합니까? 사례 시리즈 및 문헌의 체계적인 검토Case Reports Published on 2020-10-102022-09-10 Journal: European Journal of Clinical Microbiology & Infect [Category] MERS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 average Can collected data composed Conducting coronavirus disease Coronavirus-2 COVID-19 Culture culture supernatants Data collection diagnosed died explain failure Fever growth hypothese IgG in vitro in vivo inoculated Italian Local molecular test negativity occurred outcome Patient patients phenomenon positive question Re-infection Reactivation recovered patients recurrence Region replicate reported respiratory respiratory sample Respiratory samples respiratory tract specimens S protein Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Standard deviation still hospitalized study period study population supernatants Swab symptomatic patient Symptomatic patients Symptoms systematic review Vero-E6 cell Vero-E6 cells virus was performed [DOI] 10.1007/s10096-020-04057-6 PMC 바로가기 [Article Type] Case Reports
Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study라이노바이러스와 인플루엔자 A 바이러스의 간섭: 임상 데이터 분석 및 실험적 감염 연구Article Published on 2020-10-092022-09-10 Journal: The Lancet. Microbe [Category] MERS, 신종인플루엔자, 치료기술, [키워드] 95% CI Affect airway Analysis Antiviral blocking Cell culture cell cultures Clinical data co-occurrence Course COVID-19 pandemic Culture decrease Department Epidemic Epidemics epithelial Europe European country examination expected expression finding fluorescent Frame funding GFP green fluorescent protein H1N1 H1N1pdm09 host cell IAV idea inclusion criteria indicated Infection Influenza influenza A influenza A virus inhibit inoculated Interference interferon interferon response interferon-stimulated gene interferon-stimulated genes Intervention ISG ISGs medical record Medical Sciences Medicine Microscopy mock infection MOI mRNA mucosa Multiplex PCR multiplicity multiplicity of infection Odds ratio pandemic positive Post-infection primary human airway Protein quantitative PCR Replication reporter respiratory respiratory sample Respiratory samples respiratory specimen respiratory specimens respiratory virus restored resulting reverse transcription Reverse transcription quantitative PCR rhinovirus RNA Seasonal influenza significantly lower Spread Stimulation subsequent System tested the interferon Time frame USA Viral Viral RNA virus was used [DOI] 10.1016/s2666-5247(20)30114-2 PMC 바로가기 [Article Type] Article
Virological Characterization of the First 2 COVID-19 Patients Diagnosed in Italy: Phylogenetic Analysis, Virus Shedding Profile From Different Body Sites, and Antibody Response KineticsMajor Articles Published on 2020-10-022022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Analysis anatomical antibody Antibody Response assist Body carried characterization clinical manifestation clinical samples collected coronavirus COVID-19 COVID-19 case diagnosed Diagnosis early phase evaluate Hospitalization IgA IgG IgM Infection Infectious virus Italy Kinetics Laboratory longitudinal analysis Lower respiratory tract Neutralizing activity neutralizing antibody ocular Pathogenesis Patient Phylogenesis positive profile Profiling rectal rescued respiratory sample Respiratory samples response Result Saliva SARS-CoV-2 SARS-CoV-2 RNA serum serum antibody serum sample shedding specimen Surveillance swabs tested Transmission Urine viral culture Viral RNA viral RNA load Virus shedding vomit was obtained [DOI] 10.1093/ofid/ofaa403 PMC 바로가기 [Article Type] Major Articles