rhesus macaque – Page 10 – Communicable Diseases Research

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Research

Published on 2021-02-012022-10-05
Journal: Nature [Category] SARS, 비임상, 유전자 메커니즘,

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

SARS-CoV-2는 붉은 털 원숭이에서 강력한 생식 중심 CD4 T 여포 도우미 세포 반응을 유도합니다

Article

Published on 2021-01-222022-09-10
Journal: Nature Communications [Category] 진단, 치료법,

[키워드] Adaptive immunity Antibody Response Antibody responses Antiviral Blood CD4 Cell convalescent plasma COVID-19 follicular GC response GC responses generate Germinal center helper cell humoral induce induction Infectious diseases infused infusion lung lymph nodes Mild Monocytes Nucleocapsid proteins Peripheral blood plasma pro-inflammatory monocyte pro-inflammatory monocytes question receiving response rhesus rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike serum IgG antibodies skewed stimulate Tfh Tfh cell Th1 the SARS-CoV-2 Viral viral infections Viral proteins
[DOI] 10.1038/s41467-020-20642-x PMC 바로가기 [Article Type] Article

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

바리시티닙 치료는 SARS-CoV-2에 감염된 붉은털 원숭이의 하기도 대식세포 염증 및 호중구 모집을 해결합니다

Article

Published on 2021-01-212022-09-11
Journal: Cell [Category] Fulltext, SARS, 비임상, 유전자 메커니즘,

[키워드] animal animals antiviral response antiviral responses approved Baricitinib bronchoalveolar chemokine chemokines clinical trials clinically COVID-19 COVID-19 severity cytokine Cytokines Efficacy hypercytokinemia IFN immune immune activation Immunologic immunological mechanism immunology Inflammation inflammatory cells interferon investigated JAK1 JAK1/JAK2 inhibitor JAK2 lung lung infiltration Lung pathology Macrophage nasal nasal and throat swabs NETosis neutrophil neutrophil recruitment nonhuman primate Pathogenesis reduced remained responsible rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection severity Support T cell T cell response These data throat swabs tissue tissues treated Treatment two groups Type type I interferon Viral viral shedding with COVID-19
[DOI] 10.1016/j.cell.2020.11.007 PMC 바로가기 [Article Type] Article

Comparison of Subgenomic and Total RNA in SARS-CoV-2-Challenged Rhesus Macaques

Vaccines and Antiviral Agents

Published on 2021-01-202022-10-30
Journal: Journal of Virology [Category] COVID-19,

[키워드] administration anatomical antiviral drugs cell entry convalescent Critical Developing Efficacy genomic RNA gRNA in vivo inactivated infected cell Infection lysates macaque marker MONITOR monoclonal antibodies neutralized non-human primates nucleocapsid positive Prophylactic Protective public health remained replicating virus respiratory respiratory virus reverse transcription PCR rhesus macaque rhesus macaques RNA RNase RT-PCR RT-PCR assay SARS-CoV-2 SARS-CoV-2 virus sgRNA subgenomic RNA the SARS-CoV-2 virus therapeutic therapeutic efficacy Total total RNA utility Vaccines Viral load virions virus
[DOI] 10.1128/JVI.02370-20 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents

A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351

붉은 털 원숭이에서 SARS-CoV-2에 대한 강력한 효능의 인간 항체는 B.1.351에 대한 강력한 차단 활성을 나타냈습니다

Article

Published on 2021-01-012022-09-11
Journal: mAbs [Category] MERS, 변종, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody B.1.1.7 B.1.351 binding blocking activity broad-spectrum cause clinical trial Complete convalescent plasma coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 COVID-19 pandemic D614G demonstrated disease Efficacy hACE2 host cell host cell receptor in vitro Infection interact Intervention JMB2002 lead neutralization Neutralizing Neutralizing antibodies neutralizing antibody phage phage-to-yeast Phase 1 Phase 1 clinical trial platform Prophylactic Protein RBD Receptor binding domain respiratory rhesus rhesus macaque rhesus macaque disease model. SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 the RBD the SARS-CoV-2 therapeutic therapeutic efficacy Transmission Vaccine virus yeast
[DOI] 10.1080/19420862.2021.1930636 PMC 바로가기 [Article Type] Article

Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models

하이드록시클로로퀸 예방 및 치료는 원숭이와 햄스터 SARS-CoV-2 질병 모델에서 효과가 없습니다

Research Article

Published on 2020-12-032022-09-10
Journal: JCI Insight [Category] MERS, SARS, 신약개발, 진단, 치료제,

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

REGN-COV2 항체는 붉은털 원숭이와 햄스터의 SARS-CoV-2 감염을 예방하고 치료합니다.

Report

Published on 2020-11-272022-09-12
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration antibody antibody cocktail benefit clinical trials cocktail convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease described disease effective therapy Efficacy effort Epitopes evaluate evaluated Evidence evidence of golden hamster golden hamsters greatly reduce hamster hamsters host cells Human humanized in vivo limit lung titer lung titers Lungs mice Mild Mild disease Neutralizing antibodies neutralizing antibody nonoverlapping epitope nonoverlapping epitopes pandemic Pneumonia Prevent prophylactically provided REGN-CoV2 REGN10933 REGN10987 respiratory rhesus rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus severe disease severe symptoms Spike protein target therapeutic potential Therapeutics treat upper airway upper airways virus virus load weight loss
[DOI] 10.1126/science.abe2402 PMC 바로가기 [Article Type] Report

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

SARS-CoV-2에 감염된 붉은털 원숭이의 혈관 질환 및 혈전증

Case Reports

Published on 2020-11-252022-09-11
Journal: Cell [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Analysis Bronchoalveolar lavage C-reactive protein clinical Clinical features Coagulation collagen complement COVID-19 COVID-19 pandemic Critical endothelial feature Human IFNα IL-1 IL-6 IL-8 include infected with SARS-CoV-2 Inflammation Inflammatory Interaction lead lung Lungs macaque macaques Macrophage molecular morbidity and mortality MX1 NF-κB pathway performed Peripheral blood Platelet platelet activation potential therapeutic target potential therapeutic targets proinflammatory proteomic rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 pathogenesis serum thrombosis TNFα transcriptomic Transcriptomic analyses upregulation Vascular vascular disease vascular thrombosis vWF
[DOI] 10.1016/j.cell.2020.10.005 PMC 바로가기 [Article Type] Case Reports

Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation

염증을 약화시켜 SARS-CoV-2에 감염된 붉은털원숭이의 효과적인 치료

Letter to the Editor

Published on 2020-09-302022-09-12
Journal: Cell Research [Category] MERS, SARS, 진단,

[키워드] Cell Biology immunology Inflammation rhesus macaque Treatment
[DOI] 10.1038/s41422-020-00414-4 PMC 바로가기 [Article Type] Letter to the Editor

Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques

Article

Published on 2020-09-022022-10-04
Journal: Nature Communications [Category] SARS, 치료기술,