RBD-specific polyclonal F(ab´)2 fragments of equine antibodies in patients with moderate to severe COVID-19 disease: A randomized, multicenter, double-blind, placebo-controlled, adaptive phase 2/3 clinical trialResearch article Published on 2021-04-142022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 95% CI adaptive Adverse age anaphylaxis antibodies antibody assigned baseline blinded category Clinical improvement clinical scale clinical trial conducted dose double-blind Efficacy and safety Endpoint enrolled equine event finding Follow-up hazard ratio hospital hospital discharge Hospitalized hospitalized patient Immunotherapy interquartile range male Mild moderate disease Mortality multicenter neutralizing antibody Patient patients with COVID-19 patients with moderate phase 2/3 Placebo placebo-controlled placebo-controlled trial polyclonal polyclonal antibody primary endpoint Randomized Rate reached receive reported risk SARS-CoV-2 SARS-CoV-2 pneumonia severe COVID-19 Severe COVID-19 pneumonia severe disease Severe patient significantly higher statistically statistically significant difference study group subgroup analysis symptoms onset the placebo group the primary endpoint therapeutic time Treatment WHO [DOI] 10.1016/j.eclinm.2021.100843 [Article Type] Research article
Correlations between chest-CT and laboratory parameters in SARS-CoV-2 pneumonia A single-center study from ItalyObservational Study Published on 2021-04-092022-10-04 Journal: Medicine [Category] MERS, SARS, 임상, [키워드] absence Admission affected age Analysis analyzed biochemical parameter Biochemistry Biomarkers blood cell count C-reactive protein Chest computed tomography Chest CT Corona COVID-19 COVID-19 epidemic COVID-19 group CRP CT scan d -dimer damaged diagnostic double negative evaluate feature females fibrinogen fibrinogen level group in both group interstitial pneumonia Italy Laboratory laboratory parameter lactate dehydrogenase LDH lung lung damage Lymphocytes male nasopharyngeal negative RT-PCR Novel coronavirus occurred Oropharyngeal pandemic Patient Pneumonia polymerase chain positive positive RT-PCR quantification real-time reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR RT-PCR assay RT-PCR test RT-PCR tests SARS-CoV 2 SARS-CoV-2 SARS-CoV-2 pneumonia single-center study statistically significant difference Swab Volume was performed were excluded with COVID-19 [DOI] 10.1097/MD.0000000000025310 PMC 바로가기 [Article Type] Observational Study
Mortality and pulmonary complications in patients undergoing upper extremity surgery at the peak of the SARS-CoV-2 pandemic in the UK: a national cohort studyObservational Study Published on 2021-04-012022-10-05 Journal: BMJ Quality & Safety [Category] 임상, [키워드] 30-Day mortality Admission anaesthesia Analysis carried clinician cohort study Complication enrolled evaluation methodology First wave hospital hospitalised impacts include management Mortality MOST multicentre National occurred pandemic Patient patients positive postoperative primary outcome measure pulmonary complication routine safety culture SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV-2 testing screened secondary outcome standards of care surgery symptoms prior tested the SARS-CoV-2 upper limb [DOI] 10.1136/bmjqs-2020-012156 PMC 바로가기 [Article Type] Observational Study
Undetected Causes of Death in Hospitalized Elderly with COVID-19: Lessons from AutopsyArticle Published on 2021-03-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] alveolar damage Autopsy cardiovascular disease Care cause causes Clinical finding Comorbidities Comorbidity Complication complications conducted contributed coronavirus disease correlation COVID-19 death diagnose Diagnosis died elderly elderly patients FIVE heart failure Hospitalized hypertension hypoxemic lesson median median age Mortality occurred Older older patient Organizing pneumonia Pathological examination Patient patients died performed positive Post-mortem proliferative Respiratory failure retrospective SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia [DOI] 10.3390/jcm10071337 PMC 바로가기 [Article Type] Article
The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcomeCOVID-19 결과 예측에서 심장 손상, 염증 및 응고 사이의 관계Article Published on 2021-03-222022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 진단, [키워드] abnormality adverse outcome anticoagulation treatment association attenuate attenuation benefit change Coagulation Coagulopathy Complication confounders consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality CRP D-dimer determinant Effect Endpoint enrolled greater heparin Hospitalized In-hospital individuals Inflammation Inflammatory Inflammatory response Injury low molecular weight low molecular weight heparin mechanism Mortality observational study outcome PaO pathway Pneumonia Predictive markers primary endpoint Prognostic markers risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia sensitivity severity single-center subject therapy Treatment troponin T [DOI] 10.1038/s41598-021-85646-z PMC 바로가기 [Article Type] Article
Antibody titers and rapid antigen testing in elderly patients with SARS-CoV-2 pneumonia vs. staff of ICU and “Covid-19” wardsArticle Published on 2021-03-152022-11-01 Journal: GMS Hygiene and Infection Control [Category] COVID-19, [키워드] antibodies antibody Antibody Response Antibody titer Antigen assumed comorbid patient Comorbidity Course COVID-19 Elderly patient ELISA ICU IgA IgG Inc individuals Infection intensive care less majority measure Older onset of symptom Patient patients hospitalized PerkinElmer Prevalence Protective Rapid rapid antigen testing risk of infection robust Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia serology significantly the antibody response the disease the SARS-CoV-2 Viral load was determined were measured with COVID-19 [DOI] 10.3205/dgkh000382 PMC 바로가기 [Article Type] Article
Impact of previous exposure to systemic corticosteroids on unfavorable outcome in patients hospitalized for COVID-19Research Article Published on 2021-03-112022-10-28 Journal: BMC Pharmacology & Toxicology [Category] COVID-19, [키워드] 95% CIs 95% confidence interval absence adjusted Admission age calculated chronic Cohort Comorbidities Comorbidity Corticosteroid COVID-19 COVID-19 severity death Evidence exposure to France hospital Hospital admission hospitalized patient Impact increased risk inflammatory disease intensive care intensive care unit mechanical ventilation men Mortality Odds ratio outcome overlap Patient patients hospitalized pharmacoepidemiology polymerase chain positive Primary outcome provided question radiological Regression model Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia supplementary material systemic corticosteroid systemic corticosteroids transcriptase university variable Weighting [DOI] 10.1186/s40360-021-00480-3 PMC 바로가기 [Article Type] Research Article
MR-proADM as prognostic factor of outcome in COVID-19 patientsCOVID-19 환자에서 예후 인자로서의 MR-proADMArticle Published on 2021-03-042022-09-10 Journal: Scientific Reports [Category] 바이오마커, 치료기술, 치료법, [키워드] Admission affected Analysis assist association AUROC avoidance Bacteria Biomarker clinical clinical assessment clinical phenotype collected Complete COVID-19 patient COVID-19 patients cytokine Cytokines data set death demographic develop disease severity Escalation fungi Hospital admission IL-1B IL-6 IL-8 Inclusion Infectious diseases Inflammatory cytokines intubation Italy MR-proADM Multivariate analysis neutrophil neutrophil count Odds ratio Organ failure orotracheal intubation outcome Pathogenesis Patient Pneumonia Pragmatic Prognosis Prognostic factor Regional Retrospective analysis SARS-CoV-2 SARS-CoV-2 pneumonia scoring system sensitivity Sepsis Septic shock severe disease severity of COVID-19 significantly SOFA score specificity Therapies TNF-α Triaging trials university viruses was performed were measured WHO [DOI] 10.1038/s41598-021-84478-1 PMC 바로가기 [Article Type] Article
Low Sensitivity of Admission Lung US Compared to Chest CT for Diagnosis of Lung Involvement in a Cohort of 82 Patients with COVID-19 PneumoniaCOVID-19 폐렴 환자 82명 코호트에서 폐 침범 진단을 위한 흉부 CT와 비교한 입원 폐 US의 낮은 민감도Article Published on 2021-03-042022-09-10 Journal: Medicina [Category] SARS, 진단, 치료기술, [키워드] (Computed Tomography Abnormalities abnormality Admission calculated Chest-CT clinical evaluation Computed tomography consolidation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia crazy-paving pattern CT finding CT findings Department detect diagnostic test diagnostic tests disease Emergency emergency department Ground-glass opacities ground-glass opacity hospital integration interstitial pneumonia Involvement lung lung involvement lung ultrasound (LUS) Mild Mild disease moderate disease Nasopharyngeal swab objective Patient performed Pneumonia presenting pulmonary lesion pulmonary lesions ranged recruited reference standard Result SARS-CoV-2 SARS-CoV-2 pneumonia sensitivity severe disease subpleural with COVID-19 zone [DOI] 10.3390/medicina57030236 PMC 바로가기 [Article Type] Article
Novel outpatient management of mild to moderate COVID-19 spares hospital capacity and safeguards patient outcome: The Geneva PneumoCoV-Ambu studyResearch Article Published on 2021-03-042022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis Care cause coronavirus 2 coronavirus disease COVID-19 creating died disease Endpoint evaluated Follow-up Geneva University Hospital Health care system hospital Hospitalization hospitalizations Hospitalized majority management median Mild moderate Moderate COVID-19 novel Novel coronavirus outcomes pandemic Patient patient safety Patient satisfaction Pneumonia primary endpoint recommendation respiratory Result SARS-CoV-2 SARS-CoV-2 pneumonia Satisfaction secondary severity of COVID-19 Switzerland [DOI] 10.1371/journal.pone.0247774 PMC 바로가기 [Article Type] Research Article