SARS-CoV-2 S protein – Page 10 – Communicable Diseases Research

Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms

Article

Published on 2020-08-262022-10-29
Journal: Scientific Reports
[Category] COVID-19, MERS,

COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2

COVID-19 전염병: SARS-CoV-2에 의한 구조, 기능 및 hACE2 수용체 인식에 대한 통찰력

Review

Published on 2020-08-212022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, COVID-19, MERS,

[키워드] (RdRp ACE2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenicity caused cell membrane Characteristics Comparative analysis conformational change coronavirus Coronaviruses COVID-19 Critical Cross-species transmission death determinant Drug discovery Evolution of SARS-CoV-2 explain Factors fusion global public health glycoprotein hACE2 receptor host cell host range Human human cells Infection initiate insight knowledge mechanism pathogenic coronavirus RBD RdRP receptor Receptor-binding domain recognize reported respiratory RNA-dependent RNA polymerase S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 S protein Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 specificity the receptor-binding domain the S protein Vaccine Viral viral entry viral infection viral infections virus
[DOI] 10.1371/journal.ppat.1008762 PMC 바로가기 [Article Type] Review

Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2

Research

Published on 2020-07-162022-10-31
Journal: Eurosurveillance
[Category] COVID-19, SARS,

[키워드] Ability ACE2 acute respiratory syndrome aligned angiotensin-converting enzyme 2 antibody binding cause Cell common-cold conserved Coronavirus disease 2019 Coronaviruses COVID-19 cross-react cross-reactive cross-reactive antibodies cross-reactivity demonstrated detect diagnostic domain ELISA expressed expressing full length host cell receptor human infections immunogenic interact mAb mAbs mammalian cell MERS Middle East monoclonal antibody murine Novel coronavirus outbreak Part performed Protein raised recombinant S protein responsible Result S protein S2 subunit sandwich ELISA SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 research SARS-CoV-2 S protein SARS-CoV-2-infected cell sequence spike glycoprotein Spike protein syndrome tested the S protein while
[DOI] 10.2807/1560-7917.ES.2020.25.28.2000291 PMC 바로가기 [Article Type] Research

Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2

Virus-Cell Interactions

Published on 2020-07-132022-10-30
Journal: Journal of Virology
[Category] COVID-19, MERS,

[키워드] ACE2 ACE2 ortholog activities amplifying animal animal ACE2 Animal host animal hosts animal models bat caused cleavage coronavirus Coronaviruses COVID-19 pandemic CoVs determine effort Entry examined exhibited furin furin cleavage furin cleavage site global public health glycoprotein highest host cell host cells host range hosts human ACE2 human Angiotensin-converting enzyme human-to-animal transmission implication infect cells Infection Interaction Lentiviral particle lowest molecular basis Mutant SARS-CoV-2 pangolins Pathogenesis polybasic pseudotyped Pseudotyped virus receptor Receptor binding reservoirs S protein SARS-CoV-2 SARS-CoV-2 S protein Spike protein Support supported the S protein the S1 subunit tissue tropism Transmission Usage wild-type zoonotic transmission
[DOI] 10.1128/JVI.00940-20 PMC 바로가기 [Article Type] Virus-Cell Interactions

Immunogenicity of a DNA vaccine candidate for COVID-19

Article

Published on 2020-05-202022-10-04
Journal: Nature Communications
[Category] MERS, 치료기술,

Towards Neuro-CoViD-19

Editorial

Published on 2020-04-302022-10-28
Journal: Bioinformation
[Category] COVID-19,

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Article

Published on 2020-03-272022-10-04
Journal: Nature Communications
[Category] MERS, SARS, 변종,

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

2019 신종 코로나바이러스 수용체 결합 도메인(RBD) 특성 규명: 바이러스 부착 억제제 및 백신으로서의 RBD 단백질 개발에 대한 시사점

Article

Published on 2020-03-192022-09-06
Journal: Cellular and Molecular Immunology
[Category] Communicable Disease, COVID-19, MERS, SARS,

[키워드] 2019 novel coronavirus 2019-nCoV ACE2 ACE2 receptor ACE2-expressing cells acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 antibodies binding binding affinity causative agent characterization coronavirus coronavirus disease Coronavirus disease 2019 CoV CoV infection COVID-19 cross-neutralization cross-neutralize SARS-CoV-2 cross-react develop effective Entry inhibitor entry inhibitors enzyme exhibited fusion global public health host cells Human Immunotherapy in viral Infection inhibiting Novel coronavirus outbreak Protein RBD RBD protein Receptor-binding domain receptors respiratory S protein Safe SARS-CoV infection SARS-CoV RBD SARS-CoV RBD-based vaccine SARS-CoV RBD-based vaccines SARS-CoV RBD-induced antisera SARS-CoV RBD-specific antibodies SARS-CoV RBD-specific antibody SARS-CoV-2 SARS-CoV-2 and SARS-CoV infection SARS-CoV-2 RBD SARS-CoV-2 RBD protein SARS-CoV-2 S protein severe acute respiratory syndrome Coronavirus significantly higher specific antibodies Spike protein target the RBD protein the receptor-binding domain Therapeutics Vaccine Vaccines Viral viral attachment inhibitor viral infection viral inhibitor
[DOI] 10.1038/s41423-020-0400-4 PMC 바로가기 [Article Type] Article