The Impact of COVID-19 on Health Behavior, Stress, Financial and Food Security among Middle to High Income Canadian Families with Young ChildrenArticle Published on 2020-08-072022-10-31 Journal: Nutrients [Category] Coronavirus, MERS, [키워드] analyzed Behavior change changed children COVID-19 COVID-19 pandemic Descriptive statistics determine effective strategy exacerbated Factor family food food insecurity Health Health Behavior identify Impact impacted include income middle pandemic parent physical activity Quantitative data reported response Screen security Stress Support thematic analysis were used while [DOI] 10.3390/nu12082352 PMC 바로가기 [Article Type] Article
How to Screen Suitable Service Improve Community Health Care Services by University Students in TaiwanArticle Published on 2020-07-272022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] accounted Administered adopted Analysis Care characteristic Community community health Community Health Care community health service community health services component components Course COVID-19 pandemic eight ENhance equipment examined facilitate Factor analysis feasible Health implementation indicated interview performed postmodern education theories required Research resource resources Screen selected service student Taiwan university was performed [DOI] 10.3390/ijerph17155402 PMC 바로가기 [Article Type] Article
Physical Activity, Screen Time, and Emotional Well-Being during the 2019 Novel Coronavirus Outbreak in ChinaArticle Published on 2020-07-172022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] 95% CI activity adopted Affect ANOVA China Chinese collected confirmed COVID-19 case correlation COVID-19 COVID-19 outbreak emotional evaluate the effect Health help IMPROVE individual initial less lockdown novel pandemic participant per day physical activity positive Prevalence promotion proportion psychological Impact questionnaire recall Screen screen time sedentary lifestyle Spearman’s correlation coefficient statistical analysis time were used [DOI] 10.3390/ijerph17145170 PMC 바로가기 [Article Type] Article
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic뮤신-1 감소 화합물에 대한 고함량 검사를 통해 포스타마티닙이 COVID-19 대유행 기간 동안 급성 폐 손상에 대한 신속한 용도 변경을 위한 후보로 확인됨Article Published on 2020-06-302022-09-11 Journal: bioRxiv [Category] 비임상, [키워드] acute lung injury apical surface approved ARDS arising biochemical marker breath candidate Cell cell surface clinical development clinical outcomes clinical trial clinical trials Compound content COVID-19 pandemic distress drug drug candidate Drug repurposing Efficacy elevated epithelial cells expressed fostamatinib identify Immune thrombocytopenia inhibitor Lung disease lung epithelial cell Lung epithelial cells Lung injury membrane-bound mouse model MUC1 mucin mucosal pandemic pandemic spread Patient patients with COVID-19 predict promoted Protein provide R788 Rapid rationale reduce reduced repurposing required respiratory distress Respiratory distress syndrome reveal SARS-CoV-2 SARS-COV-2 infection Screen spleen Spread Stage standing up SYK syndrome the cell thrombocytopenia Treatment tyrosine [DOI] 10.1101/2020.06.30.180380 PMC 바로가기 [Article Type] Article
Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistanceAspergillus fumigatus 칼슘 반응성 전사 인자는 스트레스 내성, 독성 및 카스포펀진 내성을 촉진하는 세포벽 구조를 조절합니다Research Article Published on 2019-12-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activated macrophage activated macrophages Activation aspergillosis Aspergillus fumigatus calcineurin calcium calcium metabolism Calcium signaling cause caused Cell cell wall complexity Complicating disease contribute disease disease control drug drug-resistant drugs echinocandin expression functions fungal fungal cell wall fungal cell walls fungal disease gene networks Host host infection humans identify immune response immune responses increasingly Infection influence inhibit inhibitors invasive involved killing life-threatening Localization Lungs Macrophage macrophages mechanism metabolism mice modifications modulating morphology mutant Neutrophils nine osmotic Pathogenesis Pathogens pathway phosphatase polysaccharide pro-inflammatory pro-inflammatory cytokine pro-inflammatory response pro-inflammatory responses promoted reduction in regulate regulated Regulation response responses Screen signaling pathway strain Strains Stress stress response stress response mechanisms stress responses susceptible Tolerance transcription factor transcription factors transcriptomics Treatment turn unique virulence wild-type [DOI] 10.1371/journal.pgen.1008551 PMC 바로가기 [Article Type] Research Article
Genome-wide CRISPR-dCas9 screens in E . coli identify essential genes and phage host factorsE의 게놈 전체 CRISPR-dCas9 스크린. 대장균은 필수 유전자와 파지 숙주 인자를 식별합니다.Research Article Published on 2018-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition applied Bacteria Bacterial bacterial capsule bacterial gene bacterial genes bacteriophage bacteriophages capsids Cas9 Cas9 RNA-guided nuclease catalytic Cell chromosome colanic acid convenience CRISPR CRISPR-Ca CRISPR-dCas9 screen CRISPRi dCas9 dCas9 protein detect E . coli expression level Factor functional Gene Expression Genes Genetic genetic interactions genetic screens Genome genomes growth guide RNA High-throughput genetic screen High-throughput genetic screens highlight highlighting Host identify infection process Interaction involved kill library mechanism medium modulate mutant over pathway phage phage λ phages phages λ phenotype Phenotypes Plasmid powerful tool predict progeny random remained reported required resistance mechanism Screen sgRNA sgRNAs technique tested transduction assay utility [DOI] 10.1371/journal.pgen.1007749 PMC 바로가기 [Article Type] Research Article
Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1단백질 키나제 Cak1의 발현 감소를 통한 칸디다 알비칸스 필라멘트/생물막 조절기 우회Research Article Published on 2016-12-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation antimicrobial Antimicrobials bacterial pathogen biofilm bypass Candida Candida albican Candida albicans Cell cell cycle cell growth cell proliferation contribute coupling dependence determinant diminished Effectiveness Express expresse expression Filamentous functional Gene Expression Genes growth implicated induce Infection infections information inhibition invasive kinase leads Medical devices Mutation occur organism pathogen Pathogens proliferation property Protein protein kinase reduced regulator Regulatory required Screen Stimulation strain Strains Target genes the cell transcription factor transcription factors wild-type [DOI] 10.1371/journal.pgen.1006487 PMC 바로가기 [Article Type] Research Article
A Chemical-Genomic Screen of Neglected Antibiotics Reveals Illicit Transport of Kasugamycin and Blasticidin S방치된 항생제의 화학-유전체 검사에서 Kasugamycin 및 Blasticidin S의 불법적인 수송이 밝혀졌습니다Research Article Published on 2016-06-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] antibiotic Antibiotic resistance Antibiotics Antimicrobials approaches Bacteria Bacterial bacterial cell bacterial cells bacterial gene bacterial genes bacterial species biochemical blasticidin cells characterized compounds Critical determinant determinants determine disease E . coli Efficacy Escherichia coli Evidence Factor Fighting fire blight gene function Genetic genetic factors identify include investigated K-12 kasugamycin knowledge Loss mechanism microbe microbes Mutation Neglected open overlapping Pathogens peptide question reason reason for reduce Screen starting susceptibility targets these compound these compounds treat understanding [DOI] 10.1371/journal.pgen.1006124 PMC 바로가기 [Article Type] Research Article
Application of serologic assays for diagnosing acute hepatitis E in national surveillance of a nonendemic areaComparative Study Published on 2014-04-012023-06-11 Journal: Journal of medical virology [Category] E형 간염, [키워드] Diagnosis ELISA hepatitis E virus IgM nonendemic Screen [DOI] 10.1002/jmv.23785 [Article Type] Comparative Study
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway류마티스 관절염의 인간 유전학은 CD40 신호 전달 경로의 고처리량 약물 검사를 안내합니다Research Article Published on 2013-05-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated After allele Analysis approved drug Arthritis association Author B cells B lymphocyte B lymphocytes Biology can be used CD19+ CD40 CD40 ligand CD40 signaling Cell cell line chemical compounds clinical care coding Combination complex Compound consequence controls correlation counter deep sequencing develop disease drug Drug discovery drugs effort eQTL ExoN exonic explain expression finding Follow-up gain-of-function Genetic genetic findings Genome-wide association studies Genome-wide association study genotyping guide GWAS healthy control homozygous Human Human genetics identify implicated increase individuals Infection Inflammation inhibit inhibitor loci locus lymphocyte Lymphocytes mononuclear cell mononuclear cells mouse NF-kB NF-κB NF-κB signaling non-risk allele observé p65 pathway Patient Peripheral blood Peripheral blood mononuclear cells Phosphorylation Protein Quantitative RA RELA reporter retroviral Rheumatoid rheumatoid arthritis risk risk allele Screen second Sequencing seropositive Signaling single SNP small molecule Small molecules small-molecule screen subject subunit therapy trait traits transcription factor treat variant while [DOI] 10.1371/journal.pgen.1003487 PMC 바로가기 [Article Type] Research Article