Measurements of SARS-CoV-2 antibody dissociation rate constant by chaotrope-free biolayer interferometry in serum of COVID-19 convalescent patients코로나19 회복기 환자의 혈청 내 무카오트로프 생물층 간섭계를 통한 SARS-CoV-2 항체 해리율 상수 측정Article Published on 2022-08-012022-09-12 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, [키워드] Antibody concentrations avidity binding binding interaction binding kinetics Biolayer interferometry BLI children Clinical use clinical utility coated with convalescent COVID-19 patients COVID-19 COVID-19 convalescent patient COVID-19 convalescent patients COVID-19 patient Critical demonstrated dissociation dissociation rate Dissociation rate constant Efficiency functional intensity Kinetics knowledge Lower measurement non-specific pediatric probe RBD Real-time monitoring Receptor binding domain reduction reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike protein sera serum serum albumin serum antibody Vaccines were measured [DOI] 10.1016/j.bios.2022.114237 PMC 바로가기 [Article Type] Article
Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodiesArticle Published on 2022-08-012022-11-15 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] affected analyzed auto-antibody autoantibodies benefit Biomarker circulating Clinical outcome clinical parameter clinically Cohort COVID-19 COVID-19 patient Critical Critically ill critically ill patients defined detectable disease Effect ELISA evaluated FIVE hospital Hospital admission hospitalized COVID-19 patient identification IFN-α interferon male Neutralization assay Neutralizing Neutralizing activity Oxygen requirement Patient post-symptom onset Prevalence probability of survival Rapid reduced SARS-CoV-2 SARS-CoV-2 antibody sera severe COVID-19 specificity subsequent survival Therapeutic plasma exchange Therapies TPE Type type I interferon undetectable uninfected control WHO [DOI] 10.1007/s10875-022-01252-2 PMC 바로가기
Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5SARS-CoV-2 오미크론 하위 변이체 BA.2.12.1, BA.4 및 BA.5에 의한 항체 회피Article Published on 2022-08-012022-09-11 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Analysis antibodies antibody antigenic bebtelovimab breakthrough infections Clinical use COVID-19 vaccine COVID-19 vaccines dominant Efficacy evade facilitate individual lead Lineage Mutation Neutralizing antibodies omicron raise receptor Receptor-binding domain Region residue SARS-CoV-2 sera South Africa Spike protein Spike proteins the receptor-binding domain the United State therapeutic therapeutic antibodies United States vaccine breakthrough infections Viral yielding [DOI] 10.1038/s41586-022-05053-w PMC 바로가기 [Article Type] Article
Limited neutralisation of the SARS-CoV-2 Omicron subvariants BA.1 and BA.2 by convalescent and vaccine serum and monoclonal antibodies회복기 및 백신 혈청 및 단일 클론 항체에 의한 SARS-CoV-2 오미크론 하위 변이체 BA.1 및 BA.2의 제한된 중화Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 addition antibody BA.1 BA.2 BNT162b2 booster booster dose booster vaccination breakthrough infections Casirivimab Cell Complete convalescent convalescent sera Delta dominant dose education Efficacy elicited exhibited expressing Frankfurt Imdevimab Immunity in vitro study individual infection with SARS-CoV-2 Limited majority median monoclonal antibodies monoclonal antibody monoclonal antibody therapy Mutation neutralisation neutralise neutralising neutralizing capacity omicron Omicron variants reduced Region SARS-CoV-2 sera serum Sotrovimab specific resistance Spike protein supported tested the SARS-CoV-2 the spike protein therapy TMPRSS2 university vaccination Vaccine Vaccines variants variants of SARS-CoV-2 waning immunity [DOI] 10.1016/j.ebiom.2022.104158 PMC 바로가기 [Article Type] Article
Neutralizing antibody activity against 21 SARS-CoV-2 variants in older adults vaccinated with BNT162b2BNT162b2 백신을 접종한 노인의 21개 SARS-CoV-2 변이체에 대한 항체 활성 중화Article Published on 2022-08-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] Adults analysed antibody Antibody responses antigenic Antiviral B.1.1.529 B.1.351 B.1.617.2 Beta BNT162b2 Booster vaccine booster vaccines change clinically Cohort COVID-19 disease cross-protection Delta detectable disease domain dose Effectiveness elicit enzyme enzyme-linked immunosorbent assays examined group individual individuals median mitigate neutralization Neutralizing antibodies neutralizing antibody Neutralizing antibody response neutralizing antibody responses neutralizing antibody titre neutralizing antibody titres of BNT162b2 Older Older adults omicron Pfizer-BioNTech pseudotype RBD responsible SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants sera serious COVID-19 Spike protein Spike proteins spike variants titre Vaccine vaccine dose variant variants wildtype [DOI] 10.1038/s41564-022-01163-3 PMC 바로가기 [Article Type] Article
Reduced binding activity of vaccine serum to omicron receptor-binding domain오미크론 수용체 결합 도메인에 대한 백신 혈청의 감소된 결합 활성Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus-2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody assays be positive binding binding activity blood sample China Chinese collected contribute coronavirus disease Coronavirus disease 2019 COVID-19 dimeric domain dropped E. coli Efficacy ELISA expressed homogeneous humoral immunized investigated lateral flow LFD monomeric omicron Omicron variant participant positive prototype raise RBD RBDs reactivity Receptor-binding domain regimen SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant sera serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein Spread subject the SARS-CoV-2 the spike protein Transmission vaccination Vaccination strategy Vaccine variant [DOI] 10.3389/fimmu.2022.960195 PMC 바로가기 [Article Type] Article
Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses8개의 SARS-CoV-2 변이체의 교차 반응성은 사베코바이러스의 면역원성 클러스터링을 합리적으로 예측합니다Article Published on 2022-07-272022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Administered Algorithm Analysis antigenicity Antisera Beta booster clade Clustering dose eight elicit evaluate guinea pigs Immune escape immune evasion immunized immunogens in silico information neutralization activity neutralize Neutralizing antibodies neutralizing antibody omicron other variants PIGS predict predicted pseudotyped quantification reduced Reinfection reported sarbecovirus Sarbecoviruses SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein Structure Vaccines variant variants variants of interest VoC VOCs VOI VOIs were used [DOI] 10.1038/s41392-022-01123-7 PMC 바로가기 [Article Type] Article
A gold nanoparticle-protein G electrochemical affinity biosensor for the detection of SARS-CoV-2 antibodies: a surface modification approachSARS-CoV-2 항체 검출을 위한 금 나노입자-단백질 G 전기화학적 친화성 바이오센서: 표면 변형 접근법Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] alcohol anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody approach biosensor blocking agent change Community COVID-19 demonstrated detect determine electrode ELISA assay fused gold horseradish peroxidase IDE IgG Modification positive probe Protein protein G purified S protein SARS-CoV-2 sensitivity sera serum spike Spread VINYL ALCOHOL were used [DOI] 10.1038/s41598-022-17219-7 PMC 바로가기 [Article Type] Article
Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccinesCOVID-19 mRNA 백신에 의해 유도된 항체에 의한 SARS-CoV-2 변이체의 차등 중화 및 억제Article Published on 2022-07-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha antibody Beta booster collected coronavirus COVID-19 mRNA vaccine COVID-19 pandemic Delta disease dose effective elicited Epsilon Eta Evolution exacerbated Factor Gamma International Iota Lambda Lineage moderate mRNA mRNA vaccine National neutralization Neutralizing activity omicron Omicron variant reductions in Replication respiratory risk SARS-CoV-2 SARS-CoV-2 variant sera severe acute respiratory syndrome Coronavirus vaccination Vaccine vaccine-induced antibodies variant variants VoC VOCs VOIs Zeta [DOI] 10.1038/s41467-022-31929-6 PMC 바로가기 [Article Type] Article
Template-Based Assembly of Proteomic Short Reads For De Novo Antibody Sequencing and Repertoire ProfilingDe Novo 항체 시퀀싱 및 레퍼토리 프로파일링을 위한 Proteomic Short Read의 템플릿 기반 어셈블리Review Published on 2022-07-262022-09-11 Journal: Analytical Chemistry [Category] MERS, 유전자 메커니즘, 진단, [키워드] Accuracy antibody antibody repertoire antibody sequence antibody sequences antigens assembly B-cells cDNA sequencing complementary dataset de novo disease Fab feature fluids foundation functional Health homologous homologous antibody hypermutation IgG information light chains Liquid chromatography mass mass spectrometry molecular monoclonal antibody offer Patient patients hospitalized polyclonal polyclonal antibodies polyclonal antibody Profiling proteomic provide Read Recombination repertoire secreted sequence Sequencing sera serological assays serum step Stitch Urine with COVID-19 [DOI] 10.1021/acs.analchem.2c01300 PMC 바로가기 [Article Type] Review