Identification of Residues of SARS-CoV nsp1 That Differentially Affect Inhibition of Gene Expression and Antiviral SignalingResearch Article Published on 2013-04-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activities activity Amino acid analyzed Antiviral antiviral signaling coronavirus Critical drugs drugs targeting Epidemic evade expression Factor greater help Host host gene expression host response identification inhibit inhibition inhibitory inhibitory activity innate immune response interact interferon involved led to mutant Mutation non-structural protein pathway Protein residue residues respiratory SARS-CoV severe Signaling solvent suggested susceptible virus [DOI] 10.1371/journal.pone.0062416 PMC 바로가기 [Article Type] Research Article
Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory virusesArticle Published on 2013-04-292022-11-01 Journal: Virus research [Category] Coronavirus, 신종인플루엔자, [키워드] activating alveolar cell alveolar epithelial cell alveolar epithelial cells ATII Cell cell type cells contribute coronavirus correlated Critical Culture cytokine cytokine expression cytokine response Cytokines determine determined different disease severity epithelial cell exhibited Express expression Factor H1N1 Host IAV identify IL-1β immune responses in vitro model in vivo increased expression Infected Infection influenza A influenza A virus lung Lungs maintain Mouse-adapted SARS-coronavirus mouse-adapted SARS-CoV mRNA murine murine coronavirus murine model Pathogenesis pathology phenotype quantified respiratory viral infection respiratory virus respiratory viruses response robust SARS-CoV severe spread to susceptibility susceptible target type I Type I pneumocyte Type II pneumocyte v2163 viral infection viral infections viral pathogenesis virus viruses while [DOI] 10.1016/j.virusres.2013.04.008 PMC 바로가기 [Article Type] Article
Ezrin Interacts with the SARS Coronavirus Spike Protein and Restrains Infection at the Entry StageResearch Article Published on 2012-11-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Amino acid amino-acid Cell cellular Cluster complex coronavirus cysteine cytosol dependent on domain dominant negative early stage eight endodomain envelope fusion epithelial cells event ezrin Factor finding found glycoprotein host cell membrane in vitro Infection interact Interaction Lentiviral particle limit linker mechanism membrane fusion molecular mechanisms Particle performed pseudotyped regulate Regulation respiratory RNA S-pseudotyped particle SARS-CoV SARS-CoV S severe spike Stage susceptibility targeting VERO E6 cells viral envelope virus entry Virus life cycle yeast [DOI] 10.1371/journal.pone.0049566 PMC 바로가기 [Article Type] Research Article
Human Monoclonal Antibodies against Highly Conserved HR1 and HR2 Domains of the SARS-CoV Spike Protein Are More Broadly NeutralizingResearch Article Published on 2012-11-212022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Amgen antibody binding conserved convalescent patient different ectodomain effective expressing glycoprotein Human Human monoclonal antibody immune implication Infected isolates monoclonal antibody neutralize Neutralizing Patient produced Pseudotyped virus Receptor binding domain Region respiratory S protein S1 domain S2 domain SARS-CoV SARS-CoV spike sequence sera severe shown Subunit vaccine the S protein therapeutic therapy Treatment variant viruses [DOI] 10.1371/journal.pone.0050366 PMC 바로가기 [Article Type] Research Article
Virus Pathogen Database and Analysis Resource (ViPR): A Comprehensive Bioinformatics Database and Analysis Resource for the Coronavirus Research CommunityArticle Published on 2012-11-192022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] 3D Structures Analysis annotation annotations bioinformatics Community Comparative genomics Comprehensive Coronaviridae Coronaviridae family coronavirus database diagnostics Epitopes facilitate genomes Host immune Multiple sequence alignment pathogen Pathogens Phylogenetic phylogenetic inference Protein provide Record reference genome related viruses Research respiratory returned SARS SARS-CoV sequence sequence variation severe statistical analysis structures Support the Coronaviridae transfer Vaccine virus [DOI] 10.3390/v4113209 PMC 바로가기 [Article Type] Article
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus PathogenesisReview Published on 2012-11-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein accessory proteins acute respiratory syndrome affected caused cellular China coronavirus country Effect eight ENCODE expression functional Genome homologous homologues human-to-human transmission infected individual infected individuals Infection Isolation knowledge membrane mortality rate Novel coronavirus nucleocapsid Open reading frame open reading frames ORFs predicted Protein Proteins reported Research respiratory Respiratory disease resulting role SARS-coronavirus SARS-CoV severe Spread subsequent unique virus [DOI] 10.3390/v4112902 PMC 바로가기 [Article Type] Review
Factors associated with severe disease from malaria, pneumonia and diarrhea among children in rural Tanzania – A hospital-based cross-sectional study탄자니아 농촌 지역 아동의 말라리아, 폐렴 및 설사로 인한 중증 질환과 관련된 요인 - 병원 기반 단면 연구Research Article Published on 2012-09-142024-08-13 Journal: BMC Infectious Diseases [Category] 말라리아, [키워드] dehydration diarrhea malaria Non-severe Pneumonia severe [DOI] 10.1186/1471-2334-12-219 PMC 바로가기 [Article Type] Research Article
Temporal trends in severe malaria in Chittagong, Bangladesh방글라데시 치타공의 중증 말라리아의 시간적 추세Research Published on 2012-09-122024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Bangladesh Epidemiology Falciparum incidence malaria severe Vivax [DOI] 10.1186/1475-2875-11-323 PMC 바로가기 [Article Type] Research
Residue analysis of a CTL epitope of SARS-CoV spike protein by IFN-gamma production and bioinformatics predictionResearch Article Published on 2012-09-102022-10-28 Journal: BMC Immunology [Category] Coronavirus, Fulltext, MERS, [키워드] acute respiratory syndrome Alanine Analysis ANN antigenic epitopes ARB binding bioinformatics caused cells CTL CTL epitope demonstrated DNA electrostatic ELISA epitope exaggerate FACS functional hydrophobic IFN-gamma immunized mice induce Infectious disease Interaction lysine mutant mutated Novel coronavirus peptide peptides predicted replaced reported residue Result S protein SARS CoV SARS-CoV SARS-CoV S SARS-CoV spike protein severe Spike protein splenocyte steric T cell epitope TCR the binding affinity the mean was used [DOI] 10.1186/1471-2172-13-50 PMC 바로가기 [Article Type] Research Article
The prognostic value of schizontaemia in imported Plasmodium falciparum malaria수입된 플라스모디움 팔시파룸 말라리아에서의 분열체혈증의 예후적 가치Research Published on 2012-08-282024-08-13 Journal: Malaria Journal [Category] 말라리아, [키워드] Falciparum import malaria Prognosis schizont severe [DOI] 10.1186/1475-2875-11-301 PMC 바로가기 [Article Type] Research