severe cases – Page 10 – Communicable Diseases Research

Remdesivir; molecular and functional measures of mitochondrial safety

렘데시비르; 미토콘드리아 안전성의 분자 및 기능적 측정

Article

Published on 2021-12-152022-09-11
Journal: Toxicology and applied pharmacology [Category] 치료제,

Identifying Putative Causal Links between MicroRNAs and Severe COVID-19 Using Mendelian Randomization

멘델식 무작위화를 사용하여 MicroRNA와 심각한 COVID-19 사이의 추정 인과 관계 식별

Article

Published on 2021-12-112022-09-11
Journal: Cells [Category] SARS, 바이오마커,

[키워드] approaches assessment Biomarker Biomarkers canonical Causal causal relationship Causality caused circulating circulating miRNA circulating miRNAs COVID-19 COVID-19 case COVID-19 cases COVID-19 severity death diagnose early treatment Effect eQTL evaluated expression data group GWAS summary statistics help identify identifying imperative IMPROVE independent investigated measure mendelian randomization microRNA miRNA miRNA biomarker miRNA expression miRNAs Multiple Multiple studies outcomes pandemic phenotype Prognosis provide retrieved risk Risk assessment risk assessments SARS-CoV-2 severe cases severe COVID-19 shown unique with COVID-19
[DOI] 10.3390/cells10123504 PMC 바로가기 [Article Type] Article

Association between serum inflammatory parameters and the disease severity in COVID‐19 patients

COVID -19 환자의 혈청 염증 파라미터와 질병 중증도 사이의 연관성

Research Article

Published on 2021-12-072022-08-31
Journal: Journal of Clinical Laboratory Analysis [Category] 바이오마커,

[키워드] age analyzed Blood blood test blood tests C‐reactive protein causative agent clinician correlation count COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 criteria CRP Cytokines develop diagnosed difference disease disease severity enrolled erythrocyte sedimentation erythrocyte sedimentation rate ESR evaluate Gender groups help ICU admission IL‐6 IL‐6 increase in Inflammatory cytokine Inflammatory cytokines Inflammatory marker inflammatory markers inflammatory parameter Iran lymphocyte Lymphocytes marker measurement mild symptoms MONITOR Most patient Most patients neutrophil Neutrophils no significant difference Novel coronavirus objective Patient patients predict Prognosis Result SARS‐CoV‐2 SARS‐CoV‐2 sedimentation rate serum Serum level serum levels severe cases severe group Severe patient severe patients severity severity and prognosis significant decrease significant difference significant differences significantly higher the disease TNF‐α TNF‐α two group two groups
[DOI] 10.1002/jcla.24162 PMC 바로가기 [Article Type] Research Article

Host-modifying drugs against COVID-19: some successes, but not yet the breakthrough

COVID-19에 대한 숙주 변형 약물: 일부 성공, 그러나 아직 돌파구 없음

Review

Published on 2021-12-012022-09-11
Journal: Environmental microbiology [Category] meta-analysis, SARS, 임상, 치료제,

[키워드] Anakinra anti-inflammatory treatment antibiotic anticoagulation antiviral drug antiviral drugs Azithromycin Baricitinib benefit clinical clinical benefit clinical benefits clinical trial clinical trials Colchicine Corticosteroid COVID-19 patients criteria demonstrated Dexamethasone drug Effect hospitalized patient hospitalized patients hyperinflammation immunomodulators immunomodulatory activity Infection inferiority inhibitor interleukin 6 interleukin 6 receptor Janus kinase Kinase inhibitor Meta-analysis Microbiology Mortality no effect no effects outcome oxygen pathology Patient receptor receptor antagonist reducing Repurposed drug Repurposed drugs SARS-CoV-2 virus severe cases stages subgroups of patient supplementary oxygen survival the SARS-CoV-2 virus therapeutic dose Tocilizumab Treatment Trial Ventilation
[DOI] 10.1111/1462-2920.15828 PMC 바로가기 [Article Type] Review

Hemoperfusion and blood purification strategies in patients with COVID-19: A systematic review

COVID-19 환자의 혈액 관류 및 혈액 정화 전략: 체계적인 검토

Article

Published on 2021-12-012022-09-11
Journal: Artificial organs [Category] 바이오마커, 치료제,

[키워드] Admission antagonist approach article artificial liver asymptomatic infection Blood Blood purification Case series case sery Characteristics clinical evidence clinical trials conducted control group coronavirus coronavirus disease Coronavirus disease-19 Corticosteroid Corticosteroids COVID-19 COVID-19 patient cytokine cytokine removal Cytosorb database decrease described Evidence FIVE hemoadsorption Hemoperfusion IL-6 Inflammation intensive care intensive care unit interleukin interleukin-6 Methodological quality Mortality MOST outcome oXiris Patient patients Population pro-inflammatory state Prospective Randomized receptor receptor antagonists reduced reported Severe case severe cases Support supported supportive therapies supportive therapy suppression systematic review therapy Toraymyxin Treatment Variability Ventilation
[DOI] 10.1111/aor.14078 PMC 바로가기 [Article Type] Article

Heterogeneous expression of ACE2 and TMPRRS2 in mesenchymal stromal cells

간엽 기질 세포에서 ACE2 및 TMPRRS2의 이질적 발현

Short Communication

Published on 2021-11-242022-09-10
Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단, 치료기술, 치료제,

[키워드] ACE2 ACE2 expression ACE2 receptor adipose Adipose tissue adult stem cells binding Bone marrow Cell cell therapies cellular therapy chemokine chemokines COVID‐19 COVID‐19 infection cytokine Cytokine storm Cytokines effective enrolled expression followed by Human immune immunomodulatory factor immunomodulatory factors implicated in some Infection mesenchymal stem cell Mesenchymal stem cells mesenchymal stromal cells (MSCs) MSC MSCs multiple organ failure Organ failure outbreak potential treatment option Proinflammatory cytokine proinflammatory cytokines public health emergency SARS‐CoV‐2 SARS‐CoV‐2 secrete Severe case severe cases shown stromal cell suggested suppress target therapy tissue tissue source TMPRSS2 treat Treatment Trigger triggers umbilical Umbilical cord Vaccine virus
[DOI] 10.1111/jcmm.17048 PMC 바로가기 [Article Type] Short Communication

Assessment of Sequelae of COVID-19 Nearly 1 Year After Diagnosis

Medicine

Published on 2021-11-232022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

[키워드] 6-min walking test 6MWT age All participant Antibody test Anxiety asked assessment Blood Chest CT Complete consequence correlated correlation COVID-19 COVID-19 in patient COVID-19 patient CT findings Depression Diagnosis diffusion discharged duration of hospitalization enrolled evaluate expiratory fasting blood fatigue fibrosis Follow-up follow-up study FVC GGO Glucose ground-glass opacity Health hospital IgG IgG test Immunoglobulin impairment infected with SARS-CoV-2 Infection IQR joint Kidney function less liver long-term COVID-19 Long-term follow-up lung capacity Mild moderate multi-system assessment nodules Non-severe case non-severe cases non-severe patient Pain Patient patients performed proportion Psychological pulmonary Pulmonary function Pulmonary function test Quality of life questionnaire Reinfection reported SARS-CoV-2 Sequelae Severe case severe cases severity Shortness of breath shown Sleep study population survivor Symptom Symptoms the median the patient these symptoms union Volume was performed Wuhan Year
[DOI] 10.3389/fmed.2021.717194 PMC 바로가기 [Article Type] Medicine

Metabolomic diferences between COVID-19 and H1N1 influenza induced ARDS

Research

Published on 2021-11-152022-11-01
Journal: Critical Care [Category] COVID-19, MERS, 신종인플루엔자,

[키워드] alteration Amino acid Analysis analyzed ARDS Biomarker cause characteristic characterized Conference Coronavirus disease 2019 COVID-19 COVID‐19 defined Diagnosis distress etiologies Glycolysis groups H1N1 influenza identify induce Inflammatory intensive care involved lipid metabolism Lung inflammation maintain management metabolic pathway metabolism metabolomic metabolomics multivariate NMR noradrenaline oxidative stress pathway Pathways Patient patients with ARDS patients with COVID-19 Pneumonia Prognosis Pulmonary edema Regulation resonance Respiratory failure responses Result serum sample severe cases specificity Spectroscopy supplementary material Support syndrome was performed were used
[DOI] 10.1186/s13054-021-03810-3 PMC 바로가기 [Article Type] Research

Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis

실제 연구에서 SARS-CoV-2 백신의 효과 및 안전성: 체계적인 검토 및 메타 분석

Review

Published on 2021-11-142022-09-10
Journal: Infectious Diseases of Poverty [Category] MERS, SARS, 변종,

[키워드] 95% CI 95% confidence interval Admissions adverse event adverse events Alpha Alpha variant Beta Beta variant coronavirus disease Coronavirus disease 2019 Coverage COVID-19 COVID-19 vaccine COVID-19 vaccines COVID-19-related death death delta variant dose effective Effectiveness evaluate examined Final Gamma global pandemic herd immunity Hospitalization ICU ICU admissions immune immune surveillance Immunity inception incidence rate increasingly Infection intensive care unit Meta-analysis Mutation observational studies observational study pandemic Prevent protective effect random-effects Rapid reduce Result resulting Safety SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variants searched severe adverse events severe cases single dose supplementary material Surveillance symptomatic symptomatic cases symptomatic COVID-19 systematic review vaccination Vaccine variant variants Web of Science were used
[DOI] 10.1186/s40249-021-00915-3 PMC 바로가기 [Article Type] Review

Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2

Pharmacology

Published on 2021-11-112022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,