Remdesivir therapy causing bradycardia in COVID-19 patients: Two case reportsArticle Published on 2021-08-122022-10-04 Journal: IDCases [Category] 치료제, [키워드] Admission adverse event antiviral drug bradycardia cardiac adverse events cardiac toxicity Case report coronavirus disease correlation COVID-19 COVID-19 patient effective therapy Healthcare provider hospitalized patient intensive care intrinsic mechanism MONITOR observational study Oxygen requirements pandemic Patient public health pursuit QTc interval Remdesivir reported required SARS-CoV-2 Severe COVID-19 pneumonia the patient therapy Till Viral pneumonia worsening [DOI] 10.1016/j.idcr.2021.e01254 PMC 바로가기 [Article Type] Article
Complete Heart Block as a Clinical Feature in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients: A Case Series of Three CasesCase Series Published on 2021-08-112022-10-31 Journal: Case Reports in Critical Care [Category] COVID-19, [키워드] 24 hours block case sery cause CHB clinical Clinical characteristics Complete heart block coronary syndrome COVID-19 COVID-19 patient COVID-19 patients Critically ill diagnosed with COVID-19 disease exhibited Familial heart hemodynamic hemodynamic instability hypoxic respiratory failure Ill include infiltration intubation Lower male mechanical ventilator metabolic derangement morbidity and mortality multiorgan failure Myocardial inflammation novel outcome past medical history patients with COVID-19 potential mechanism potential mechanisms pregnant required resolved Section Sery Severe COVID-19 pneumonia Shock sinus pause Support with COVID-19 [DOI] 10.1155/2021/9955466 PMC 바로가기 [Article Type] Case Series
Impact of early corticosteroids on 60-day mortality in critically ill patients with COVID-19: A multicenter cohort study of the OUTCOMEREA networkResearch Article Published on 2021-08-042022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Admission age Comorbidity Corticosteroid COVID-19 pneumonia patient Critically ill patient death French ICU Impact increased risk Inflammation lower mortality male mechanical ventilation median median age Mortality multicenter cohort study objective Occurrence Patient patient survival patients patients with COVID-19 Pneumonia Probability required Result risk Severe COVID-19 pneumonia significantly study population subgroup survival Treatment two groups Weighting [DOI] 10.1371/journal.pone.0255644 PMC 바로가기 [Article Type] Research Article
Intravenous methylprednisolone with or without tocilizumab in patients with severe COVID-19 pneumonia requiring oxygen support: A prospective comparison산소 공급이 필요한 중증 COVID-19 폐렴 환자에서 토실리주맙을 포함하거나 포함하지 않는 정맥 내 메틸프레드니솔론: 전향적 비교Randomized Controlled Trial Published on 2021-08-012022-09-12 Journal: Journal of infection and public health [Category] SARS, 임상, 진단, [키워드] 1:1 Adding addition Administered administration Admission all-cause mortality Arm control arm control group controls coronavirus disease Course COVID-19 determine died disease severity Dubai electronic medical records exclusion criteria FIVE group highest Hospital stay ICU ICU admission IMPROVE Inclusion intensive care intravenous intravenous tocilizumab Invasive mechanical ventilation lowest marker Methylprednisolone Methylprednisolone therapy morbidity and mortality Mortality one patient outcome oxygen oxygen support Oxygen therapy Patient patients hospitalized patients treated Pneumonia Primary outcome randomization Randomized randomized controlled study rates of admission receive recruited reduce reduced retrospective SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia severity significantly significantly lower single dose survival time Tocilizumab treated Treatment usual care Ventilation ventilator while [DOI] 10.1016/j.jiph.2021.06.003 PMC 바로가기 [Article Type] Randomized Controlled Trial
Better prognosis in females with severe COVID-19 pneumonia: possible role of inflammation as potential mediatorObservational Study Published on 2021-08-012022-10-05 Journal: Clinical microbiology and infection : the official [Category] SARS, 바이오마커, 임상, [키워드] 95% CI Admission Analysis Better Biomarker C-reactive protein (CRP composite endpoint conducted COVID-19 COVID-19 pneumonia COVID-19 severity CRP death described Endpoint explain female Follow-up Hypothesis IMV Inflammation Invasive mechanical ventilation IQR less male median age mediation Mortality Observational cohort study PaO Patient patients potential mechanism predominant profile Prognosis progression provide retrospective risk risk of COVID-19 severe COVID-19 Severe COVID-19 pneumonia Sex sex differences significantly specific biomarker study period survival tested Variation [DOI] 10.1016/j.cmi.2020.12.010 PMC 바로가기 [Article Type] Observational Study
Predictive Role of Haematological Determinants on Outcomes of Critically Ill COVID-19 Patients Admitted to Intensive Care UnitEmergency Medicine Published on 2021-07-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abnormality acquired von willebrand Acute kidney injury acute kidney injury care ADAMTS13 admitted to ICU AKI alveolar damage Antigen Coagulation Combination COVID 19 COVID-19 COVID-19 patient cross-sectional D dimer D-dimer defined determinant determine disease severity evaluate extra-pulmonary organs factor VIII feature Hypoxemia hypoxic respiratory failure ICU Ill increases in intensive care intensive care unit intensive respiratory care invasive marker mechanical ventilation microthrombi Mortality multi-organ dysfunction Non-invasive outcome Patient peak peak D-dimer Pneumonia raised reference ranges required risk role SARS-CoV-2 positive patient severe COVID-19 patient Severe COVID-19 pneumonia severity significantly Thromboembolism thrombotic Vascular vasoconstriction was obtained with COVID-19 [DOI] 10.7759/cureus.16764 PMC 바로가기 [Article Type] Emergency Medicine
Soluble P-selectin as a potential diagnostic and prognostic biomarker for COVID-19 disease: A case-control studyCOVID-19 질병에 대한 잠재적 진단 및 예후 바이오마커로서의 가용성 P-셀렉틴: 사례-대조군 연구Article Published on 2021-07-152022-09-11 Journal: Life sciences [Category] SARS, 바이오마커, 진단, [키워드] 95% CI Analysis AUC Biomarker can be used case-control study Clinical severity control group COVID-19 COVID-19 disease COVID-19 infection COVID-19 infections COVID-19 patient COVID-19 patients COVID-19 pneumonia diagnosing Diagnosis diagnosis of COVID-19 diagnostic diagnostic value disease ELISA enzyme enzyme-linked immunosorbent assay greater group healthy volunteer intensive care treatment investigated knowledge Mild mild to moderate Mild-to-moderate moderate P-selectin participated Patient Pneumonia predict prognostic biomarker receiver operating characteristic ROC selectin serum serum isolation Serum soluble P-selectin levels. Severe COVID-19 pneumonia severe pneumonia statistical significance were assessed [DOI] 10.1016/j.lfs.2021.119634 PMC 바로가기 [Article Type] Article
Case Report: Human Umbilical Cord Mesenchymal Stem Cells as a Therapeutic Intervention for a Critically Ill COVID-19 PatientMedicine Published on 2021-07-082022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Antibiotics ARDS Case report China Chinese CORD Corticosteroid COVID-19 COVID-19 patient Critically ill Critically ill patient cured diagnosed disease Follow-up Hospitalization Human IL-10 IL-4 IL-6 Ill Mesenchymal stem cells modulated MSC NK cells past medical history Patient Pulmonary edema SARS-COV-2 infection Septic shock Severe COVID-19 pneumonia SIRS STEM Symptom the cytokine storm the patient therapeutic therapy Treatment with COVID-19 [DOI] 10.3389/fmed.2021.691329 PMC 바로가기 [Article Type] Medicine
Potential Impact of Diabetes and Obesity on Alveolar Type 2 (AT2)-Lipofibroblast (LIF) Interactions After COVID-19 InfectionCell and Developmental Biology Published on 2021-07-082022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 Activation acute lung injury acute respiratory syndrome addition age alveolar alveolar epithelial type 2 cells angiotensin-converting enzyme 2 assisted ventilation AT2 caused cells cellular characterized complications contributing to coronavirus COVID-19 cumulative Diabetes Mellitus Effect epithelial exacerbated response Express Factor fibrosis Impact impacted increase in infected patients Inflammation Injury LIF Lipofibroblasts metabolic disease Myofibroblast obese patients obesity outbreak oxidative stress Patient Pneumonia Potential receptor respiratory virus responsible risk factor SARS-CoV-2 SARS-COV-2 infection Severe COVID-19 pneumonia severity stem cells surviving patients the SARS-CoV-2 therapeutic Type understanding [DOI] 10.3389/fcell.2021.676150 PMC 바로가기 [Article Type] Cell and Developmental Biology
Immunomodulatory therapy, risk factors and outcomes of hospital-acquired bloodstream infection in patients with severe COVID-19 pneumonia: a Spanish case–control matched multicentre study (BACTCOVID)Original Article Published on 2021-07-072022-11-01 Journal: Clinical microbiology and infection : the official [Category] COVID-19, MERS, [키워드] 1:1 Abstract accounted acute respiratory distress Admission age Analysis Bacteraemia bloodstream BSI caused characteristics of patient Cohort combinations Control Corticosteroids COVID-19 database Enterococcus hazard ratio Hospital-acquired infection Hospitalized hospitalized patient identify Image immunomodulatory drug immunomodulatory therapy in-hospital mortality increased risk Infection IQR median time mortality risk multicentre objective outcome Patient patients patients with COVID-19 performed polymicrobial infection prospective cohort Pseudomonas aeruginosa Result risk risk factor SARS-CoV-2 pneumonia severe COVID-19 Severe COVID-19 pneumonia severity Sex Spanish syndrome therapy time factor Tocilizumab was performed with COVID-19 [DOI] 10.1016/j.cmi.2021.06.041 PMC 바로가기 [Article Type] Original Article