Clinical and Virological Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern: A Retrospective Cohort Study Comparing B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta)중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변이의 임상 및 바이러스학적 특징: B.1.1.7(알파), B.1.351(베타) 및 B.1.617.2(베타)를 비교한 후향적 코호트 연구( 델타)Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% confidence interval adjusted odds ratio Admission age age and sex analyzed B.1.1.7 B.1.351 B.1.617.2 Beta Chain Reaction clinical clinical outcomes Cohort Comorbidities coronavirus 2 COVID-19 Ct value Ct values cycle threshold death Delta disease severity higher odd higher odds implementation Infection intensive care intensive care unit admission median not seen outcome oxygen Oxygen requirement Patient patients Pneumonia polymerase chain polymerase chain reaction respiratory Retrospective study SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severity severity of illness Sex significantly lower Singapore study period surveillance data vaccination Vaccination Status variants variants of concern viral shedding VoC VOCs were infected wild-type wild-type strain [DOI] 10.1093/cid/ciab721 PMC 바로가기 [Article Type] Article
Coronavirus Disease 2019 Disease Severity in Children Infected With the Omicron Variant코로나바이러스 질병 2019 오미크론 변이체에 감염된 어린이의 질병 심각도Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted odds ratio Admission age children Control coronavirus Coronavirus 2019 COVID-19 death Delta delta variant determined by Diagnosis disease disease severity Hospital admission Hospitalization ICU ICU care Infection intensive care intensive care unit less mechanical ventilation Mild moderate omicron Omicron variant outcome outcomes Primary outcome Propensity score SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly lower variant [DOI] 10.1093/cid/ciac275 PMC 바로가기 [Article Type] Article
Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living With Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count현재 CD4 T-림프구 수를 기반으로 항레트로바이러스 치료를 받고 있는 인간 면역결핍 바이러스에 감염된 사람들의 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 mRNA 백신 접종으로 유도된 체액 및 세포 면역 반응Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 2 vaccine Against AIDS anti ART BNT162b2 booster dose CD4 CD4 T-cell cell-mediated immune comparable confounders control group controls coronavirus 2 count CoV current detectable elicited HCDR HCW HCWs healthcare worker HIV HIV-negative Human IFN-γ immune response immunogenicity magnitude mRNA mRNA-1273 NAb NAbs Neutralizing Neutralizing antibodies parameter parameters participant PLWH predicted RBD-binding antibody RBD-binding IgG receiving reduced respiratory response SARS SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly significantly lower stratified T-lymphocyte titre were measured were used [DOI] 10.1093/cid/ciac238 PMC 바로가기 [Article Type] Article
Robust T-Cell Responses in Anti-CD20-Treated Patients Following COVID-19 Vaccination: A Prospective Cohort StudyCOVID-19 백신 접종 후 항-CD20 치료 환자의 강력한 T-세포 반응: 전향적 코호트 연구Observational Study Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-CD20 anti-CD20 therapy anti-CD20 treatment antibodies antibody Antibody Response Arthritis Breakthrough infection CD20 CD4 CD4 T cell CD8 T cell CD8 T cells cohort study Complication Control controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccination COVID-19 vaccine detectable dose Effectiveness effector molecule effector molecules expressed Follow-up had no humoral humoral responses individual Mild mRNA COVID-19 vaccines mRNA-based COVID-19 vaccine multiple sclerosis Ocrelizumab Patient patients treated Prospective prospective observational cohort reduction respiratory response response rate response rates rheumatic disease Rheumatic diseases rheumatoid arthritis risk rituximab seroconverted severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease severe COVID-19 significantly lower specific antibodies spike T cell T cells T-cell T-cell Response T-cell responses Th1 phenotype treated treated patient vaccination [DOI] 10.1093/cid/ciab954 PMC 바로가기 [Article Type] Observational Study
The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID-19: a systematic review and meta-analysis Research Published on 2022-08-222022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] 95% CI 95% confidence interval Admission Analysis CIs Clinical outcome clinical outcomes COVID-19 COVID-19 pandemic COVID-19 patient database Evidence favor FIVE fixed group heterogeneity Hospital admission indicated Infection Influenza intensive care limitations mean difference mechanical ventilation Meta-analysis mortality rate no significant difference observational study outcomes Patient random effect recent reduce reducing reported Research risk searched severity severity of COVID-19 significantly lower statistically significant difference systematic review vaccination Vaccine [DOI] 10.1038/s41598-022-18618-6 [Article Type] Research
Lower brachial artery flow-mediated dilation is associated with a worse prognosis and more lung parenchymal involvement in Covid-19: Prospective observational studyObservational Study Published on 2022-08-192022-10-05 Journal: Medicine [Category] 임상, [키워드] acute respiratory disease acute respiratory syndrome angiotensin-converting enzyme 2 Biochemical parameters brachial caused Coagulopathy coronavirus disease Coronavirus-2 cutoff point D-dimer Diagnosis died discharged disease Endothelial dysfunction endothelial function evaluate evaluated ferritin Hospitalized ICU ICU admission ICU patient intensive care investigated lactate dehydrogenase Lower lung lung involvement lung parenchyma moderate Mortality mortality rate multicenter negative correlation pandemic parenchymal pathogenic coronavirus patients patients hospitalized Prognosis Prospective prospective observational study receptor resulting risk factor shown significantly lower the patient vascular inflammation virus White blood cell worse prognosis [DOI] 10.1097/MD.0000000000030001 PMC 바로가기 [Article Type] Observational Study
The Associations of Iron Related Biomarkers with Risk, Clinical Severity and Mortality in SARS-CoV-2 Patients: A Meta-AnalysisSARS-CoV-2 환자의 위험, 임상 중증도 및 사망률과 철분 관련 바이오마커의 연관성: 메타 분석Review Published on 2022-08-192022-09-11 Journal: Nutrients [Category] SARS, 바이오마커, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition article Biomarker calculation caused clinical coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression deaths disease Diseases eligible evaluate Evidence ferritin ferritin level ferritin levels hemoglobin heterogeneity indicate Infection iron Iron metabolism magnitude mean difference Meta-analysis metabolism Mortality non-survivor Non-survivors Occurrence opposite Patient peer-reviewed Previous studies previous study progression random effect respiratory risk SARS-CoV-2 searched serum severe acute respiratory syndrome Coronavirus severity significantly lower SMD Survivors the disease TIBC was used Web of Science with COVID-19 [DOI] 10.3390/nu14163406 PMC 바로가기 [Article Type] Review
Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concernSARS-CoV-2 Delta 변이체 감염은 우려되는 알파 또는 비 변이체에 비해 상기도에서 4배 증가된 바이러스 부하를 나타냅니다.Article Published on 2022-08-172022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age all age group all age groups Alpha Alpha variant B.1.1.7 B.1.617.2 coronavirus Delta delta variant dominant Evidence evidenced genomic Genomic surveillance group groups in viral no difference Older age other variants reported respiratory sample Respiratory samples Sample size SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sex significantly lower suggested Surveillance the SARS-CoV-2 Transmissibility upper airway vaccination variant variants Viral load viral loads Wuhan strain [DOI] 10.1038/s41598-022-18279-5 PMC 바로가기 [Article Type] Article
AYURAKSHA, a prophylactic Ayurvedic immunity boosting kit reducing positivity percentage of IgG COVID-19 among frontline Indian Delhi police personnel: A non-randomized controlled intervention trialClinical Trial Published on 2022-08-162022-10-04 Journal: Frontiers in Public Health [Category] SARS, 임상, 진단, [키워드] Analysis Anu AYURAKSHA kit Ayurveda Blood blood sugar C-reactive protein CD3 CD4 CD8 clinical control group controls COVID-19 COVID-19 crisis COVID-19 infection COVID-19 pandemic determine distribution dysregulated effective Efficacy effort erythrocyte sedimentation rate evaluated hematological hematological parameter hematological parameters IgG IgG positivity IL-6 IL-6 level Immunity incidence India Infection inflammation marker Intervention life lower risk Lymphocyte subset management Medicine Mortality no increase non-randomized pandemic participant Participants post-intervention Primary outcome Prophylactic Quality Quality of life Quality of life (QoL) random reduced reducing Research secondary outcome severity of COVID-19 significantly significantly lower status the WHO Trial Version [DOI] 10.3389/fpubh.2022.920126 PMC 바로가기 [Article Type] Clinical Trial
Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic EpipharyngitisEpipharyngeal Abrasive Therapy(EAT)는 만성 인두염에서 주요 전염증성 사이토카인 IL-6의 mRNA 발현을 감소시킵니다Article Published on 2022-08-162022-09-11 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] Abrasive addition aggregation Alpha analyzed anti-inflammatory effect Cell chronic chronic fatigue syndrome chronic inflammation contribute cough COVID cytokine cytokine network Cytokines Diseases effective epipharyngeal abrasive therapy (EAT) epipharyngitis epipharynx expression expression pattern fatigue fatigue syndrome Hypothesis IgA IgA nephropathy IL-6 IL-6 expression IMPROVE In situ hybridization induce Inflammatory cytokine Inflammatory cytokines Inflammatory diseases interleukin interleukin 6 interleukin 6 (IL-6) intractable involved Japan Local Long Long COVID Major mechanisms mRNA myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) nasal Nasal cavity Necrosis nephropathy Patient postnasal drip Proinflammatory cytokine reduced reported responsible Sedation significantly lower subject suggested suppressed suppression Symptom syndrome systemic inflammatory disease systemic inflammatory diseases systemic symptoms therapy TNFα treated Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha tumor necrosis factor alpha (TNFα). upper respiratory tract [DOI] 10.3390/ijms23169205 PMC 바로가기 [Article Type] Article