Combined drug repurposing and virtual screening strategies with molecular dynamics simulation identified potent inhibitors for SARS-CoV-2 main protease (3CLpro)분자 역학 시뮬레이션과 결합 된 약물 재검사 및 가상 스크리닝 전략 SARS-COV-2 주요 프로테아제 (3CLPRO)에 대한 강력한 억제제를 확인했습니다.Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, [키워드] 3CLpro accelerate anti-HIV drugs approach approved binding binding free energy Care catalytic dyad Combined confirmed case coronavirus Cys145 database death disease dissemination drug Drug screening drug-repurposing Epidemic FDA FIVE free energy Health care Health care system His41 HIV idea in viral infection rate inhibit inhibitor inhibitors intensity maturation molecular dynamics Molecular dynamics simulation pandemic pathway protease public health raised Replication reported Research saquinavir SARS-CoV-2 SARS-CoV-2 main protease screened spread to TCM tested these compound these compounds Traditional Chinese medicine traditional Chinese medicines Vaccine Viral Virtual screening [DOI] 10.1080/07391102.2020.1779128 PMC 바로가기 [Article Type] Article
Factors influencing SARS-CoV-2 transmission and outbreak control measures in densely populated settingsArticle Published on 2021-07-272022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute infection Asymptomatic case attack rate close contact Combination COVID-19 disease spread driver epidemiological Epidemiology facilitate Factor Final identify implementation IQR living environment measure Measures outbreak Phylogenetic reduce reduced SARS-COV-2 infection SARS-CoV-2 transmission serological Singapore spread to starting supported symptomatic case Transmission viral infection [DOI] 10.1038/s41598-021-94463-3 PMC 바로가기 [Article Type] Article
Spatially resolved simulations of the spread of COVID-19 in three European countriesResearch Article Published on 2021-07-202022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] Admission age approach changes in China consequence Contact Containment measure country COVID-19 outbreak death deaths European country expected fatality feature First wave Government groups hospitalisation Hospitalization Infection intensive care Intervention Italy late stage less Local measure novel SARS-CoV-2 virus occurred outbreak pandemic parameter parameters resolved responsible resulting risk SARS-CoV-2 selected Spain Spread spread of COVID-19 spread to the disease the SARS-CoV-2 virus virus [DOI] 10.1371/journal.pcbi.1009090 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearanceSARS-CoV-2 감염은 다중 섬모 세포의 역분화를 유도하고 점액 섬모 청소를 손상시킵니다Article Published on 2021-07-162022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] airway airways Basal cell Bronchial epithelium cause Cell characterized cilia ciliary ciliated cells clearance consequence decrease dedifferentiation Defense defense mechanisms Disruption downregulation epithelial expression facilitate Foxj1 functional hamster identify impair in vivo induce interferon lung parenchyma master regulator mechanism mechanisms misorientation Motile cilia Mucociliary clearance occur parameter pathogenic reconstructed reduced respiratory tract resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity of COVID-19 Spread spread to tight junctions to define transcription factor understanding viral particle [DOI] 10.1038/s41467-021-24521-x PMC 바로가기 [Article Type] Article
Emergence and Spread of B.1.1.7 Lineage in Primary Care and Clinical Impact in the Morbi-Mortality among Hospitalized Patients in Madrid, SpainArticle Published on 2021-07-152022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Admission Alpha variant B.1.1.7 B.1.1.7 lineage B1.1.7 lineage Burden of disease characterized clinical death rate declining deletions detect disease dominant emergence healthcare Impact increase in intensive care Mutation new SARS-CoV-2 no difference pandemic Patient patients treated positive result prevalent primary care Probability reached replacement respiratory sample S gene SARS-CoV-2 SARS-CoV-2 variant screened Spain Spread spread to the spike protein variant variants [DOI] 10.3390/microorganisms9071517 PMC 바로가기 [Article Type] Article
The correlation between mental health status, sleep quality, and inflammatory markers, virus negative conversion time among patients confirmed with 2019-nCoV during the COVID-19 outbreak in China: An observational studyObservational Study Published on 2021-07-092022-10-05 Journal: Medicine [Category] SARS, 임상, [키워드] 2019 coronavirus disease 2019-nCoV Analysis Anxiety Clinical characteristics collected conducted correlation COVID-19 COVID-19 outbreak cross-sectional survey Depression depressive dimension disorder immune function index indicated Inflammation Inflammatory inflammatory markers Inflammatory response information Laboratory Lymphocyte count mental health Negative conversion neutrophil count NLR participant Patient Pittsburgh platform positively correlated problem problems Psychological Quality questionnaire reported Self-Rating Depression Scale significant difference Sleep Sleep disturbance sleep quality spread to Stress Symptom total score virus was increased [DOI] 10.1097/MD.0000000000026520 PMC 바로가기 [Article Type] Observational Study
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization Research Published on 2021-07-082022-10-05 Journal: Nature [Category] 변종, [키워드] Alpha variant anti-RBD antibody Antibody neutralization AstraZeneca B.1.1.7 B.1.617 B.1.617.2 binding collected convalescent individual convalescent individuals COVID-19 COVID-19 vaccine Delta delta variant dominant dose epitope examined faster France immune evasion include India individual individual with COVID-19 individuals inhibitory effect less Lineage monoclonal antibodies monoclonal antibody Mutation N-terminal domain neutralization Neutralizing NTD onset of symptom other variants Pfizer RBD Region returned SARS-CoV-2 SARS-CoV-2 variant sensitivity sera Spike protein Spread spread to strain subtype the receptor-binding domain the SARS-CoV-2 the spike protein the vaccine titre Vaccine variants [DOI] 10.1038/s41586-021-03777-9 [Article Type] Research
Vitamin C and D supplementation and the severity of COVID-19 A protocol for systematic review and meta-analysis비타민 C 및 D 보충 및 Covid-19의 심각성 체계적인 검토 및 메타 분석을위한 프로토콜5500 Published on 2021-07-022022-08-31 Journal: Medicine [Category] COVID-19, meta-analysis, SARS, [키워드] Analysis articles association carried case studies competence condition COVID-19 COVID-19 pandemic database death determine diet Evidence evolution of patient Health heart immune system independent infections instrument limitation lung Meta-analysis mitigate nutrition organization organizations professionals protocol quest recommendation Record reduce reduction in researcher risk Risk of bias selected severe acute respiratory syndrome Coronavirus severity severity of COVID-19 Severity of infection spread to Subgroup analyses systematic review Vitamin Vitamin C Vitamin D vitamins C Web of Science with COVID-19 [DOI] 10.1097/MD.0000000000026427 PMC 바로가기 [Article Type] 5500
Impact of joint management of a COVID-19 mother and her newborn on the virus transmission: a case reportCase Report Published on 2021-06-282022-10-28 Journal: Virology Journal [Category] COVID-19, MERS, SARS, [키워드] Breastfeeding Case report caused Contact COVID-19 COVID-19 infection described facilitate Follow-up healthy Impact Infant Infection prevention Infection transmission joint management measure mother Neonatal Neonates Newborn newborn infant positive pregnant women Rooming-in SARS-CoV2 transmission spread to tested the disease Transmission virus [DOI] 10.1186/s12985-021-01598-w PMC 바로가기 [Article Type] Case Report
Knowledge, Attitude, and Practice of Healthcare Providers Toward Novel Coronavirus 19 During the First Months of the Pandemic: A Systematic ReviewPublic Health Published on 2021-06-252022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] absence addition age assessment Attitude Chronic illness CINAHL conducted contagious COVID-19 database Diagnosis disease disease spread equipment Factor Gender Google Scholar hcp Healthcare provider infection control Infection prevention information KAP knowledge median Methodological quality Month novel pandemic percentage positive attitude Practice Protective protocol Quality Registered reported review risk factor scale significantly spread to systematic review Transmission viral infection was performed [DOI] 10.3389/fpubh.2021.606666 PMC 바로가기 [Article Type] Public Health