Developing and validating a multivariable prediction model which predicts progression of intermediate to late age-related macular degeneration—the PINNACLE trial protocol Research Published on 2022-05-252022-10-05 Journal: Eye (London, England) [Category] 바이오마커, 임상, [키워드] AMD approach Biomarker Biomarkers central vision Characteristics collected correlation correlations dataset Deterioration Developing Disease progression endpoints eye feature Follow-up genotyping healthy controls identify imaging Imaging tests include individuals intermediate marker multivariable optical Optical coherence tomography outcome Patient patient data Population predict Predictive predictor Primary outcome progression Prospective Study recent recruited repeated retinal imaging retrospective retrospective cohort risk risk factor ROC curves secondary Sensitivity and specificity Stage statistical structure-function Switzerland Teaching tomography trial protocol Trigger UK biobank university utility visual function [DOI] 10.1038/s41433-022-02097-0 [Article Type] Research
CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patientsCMV 혈청 양성은 비노인 환자에서 심각한 COVID-19에 대한 잠재적인 새로운 위험 요소입니다Article Published on 2022-05-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] absence advanced age affected Analysis Biomarker CMV co-morbidities Cohort cohorts Comorbidities confirmation COVID-19 Critical cross-reactivity cytomegalovirus deaths detectable disease disease severity distribution finding herpes simplex herpes simplex virus higher risk Hypothesis ICU IgG individual individuals intensive care investigated Mild Mild disease moderate morbidities occur older patients Patient performed prediction Prevalence representing risk factor SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants serology Seropositivity serostatus severe COVID-19 severe disease statistical Support T cell T cells were used with mild disease [DOI] 10.1371/journal.pone.0268530 PMC 바로가기 [Article Type] Article
Boosting SARS-CoV-2 detection combining pooling and multiplex strategies풀링 및 다중화 전략을 결합한 SARS-CoV-2 탐지 향상Article Published on 2022-05-232022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] addition Analysis analyzed approach Brazil Combination contribute demonstrated envelope evaluated Expenditure expenditures feasible Federation gold gold standard in-silico increase in individual molecular multiplex Multiplex assay new SARS-CoV-2 nucleocapsid pandemic performed pooling Population predicted reduction in Rio de Janeiro RT-qPCR SARS-CoV-2 detection sensitivity simplex specimen state statistical targets tested variants virus spread [DOI] 10.1038/s41598-022-12747-8 PMC 바로가기 [Article Type] Article
The impact of COVID-19 on pragmatic clinical trials: lessons learned from the NIH Health Care Systems Research Collaboratory실용적인 임상 시험에 대한 COVID-19의 영향: NIH Health Care Systems Research Collaboratory에서 배운 교훈Article Published on 2022-05-212022-09-11 Journal: Trials [Category] 임상, [키워드] activities activity Administered Analysis analyzed approach benefit Care Clinical research clinical trial clinical trials collected COVID-19 COVID-19 pandemic Critical Data collection Disruption FIVE Health care healthcare high risk Impact in some independent instances Intervention iterative majority Modification modifications multiple method multiple methods NIH pandemic Pragmatic Pragmatic clinical trials principal investigator Principal Investigators qualitative data questionnaire Research Research participation. response Safe social distancing statistical System text Trial [DOI] 10.1186/s13063-022-06385-8 PMC 바로가기 [Article Type] Article
Smartphone-Guided Self-prone Positioning vs Usual Care in Nonintubated Hospital Ward Patients With COVID-19: A Pragmatic Randomized Clinical TrialResearch article Published on 2022-05-192022-10-05 Journal: Chest [Category] COVID19(2023년), SARS, 임상, [키워드] Adverse Analysis approach Bayesian calculated clinical COVID-19 Deterioration effective Effectiveness Enrollment event ICU increase in Intervention intervention arm less modified intention-to-treat multicenter occurred pandemic participant Patient patients with COVID-19 position positioning posterior probability Primary outcome progression promote prone prone positioning Randomized randomized clinical trial receive receiving recommendation reduce reducing Registration Respiratory failure Result Smartphone statistical supplemental oxygen threshold transfer Treatment treatment arm Trial usual care ward with COVID-19 [DOI] 10.1016/j.chest.2022.05.009 [Article Type] Research article
Estimating the COVID-19 infection fatality ratio accounting for seroreversion using statistical modelling Research Published on 2022-05-192022-10-05 Journal: Communications Medicine [Category] 치료법, [키워드] accounted antibody antibody waning applied Bayesian coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic dataset death disease Epidemics estimate estimates Factor fatality first-wave IFR Infection infections less parameter quantified Region Result robust Sensitivity and specificity Seroconversion specificity statistical statistical framework statistical model [DOI] 10.1038/s43856-022-00106-7 [Article Type] Research
A Robust Framework for Epidemic Analysis, Prediction and Detection of COVID-19COVID-19의 전염병 분석, 예측 및 탐지를 위한 강력한 프레임워크Article Published on 2022-05-062022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Affect Analysis center central limit theorem Chain Reaction circulation composed Coronavirus - COVID-19 country COVID COVID case COVID cases COVID-19 COVID-19 disease COVID-19 infection dataset detect detection disease disease control distribution doubling dry cough Epidemic epidemic spreading algorithm estimate estimation Evolution extreme False-positive feature Features feeble Fever flu Frame framework gaussian gaussian distribution generate Gradient histogram immune systems India individual Infection infections Infectious disease Italy Johns Hopkin Johns Hopkins limit lung mandatory mathematical mathematical model outcome pandemic parameter parameters polymerase chain polymerase chain reaction predict prediction Prevent real-time polymerase chain reaction regulated robust RT-PCR Saudi Arabia scale Spread statistical Symptom the disease thickness time evolution Time-series (TS) model Viral pneumonia widespread [DOI] 10.3389/fpubh.2022.805086 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 20212020년 3월부터 2021년 5월까지 뉴잉글랜드 남부의 SARS-CoV-2 공격률 및 인구 면역Observational Study Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] Administered agency analyzed attack attack rate Bayesian inference case sery confirmed COVID-19 case Connecticut contributing to Course Coverage COVID-19 credible interval CrI death defined delta variant distribution England Epidemic epidemic wave estimate estimates Health hospitalizations Immunity individual Infection intensive care less Massachusett Massachusetts median age New outcome pandemic Population population immunity proportion public health Rate reached reported Rhode Island SARS-CoV-2 seropositive Stage statistical summer susceptible test result uninfected vaccination Vaccine ventilator Winter [DOI] 10.1001/jamanetworkopen.2022.14171 PMC 바로가기 [Article Type] Observational Study
Artificial intelligence-inspired comprehensive framework for Covid-19 outbreak controlArticle Published on 2022-05-012022-11-16 Journal: Artificial intelligence in medicine [Category] 치료기술, [키워드] Accuracy Analysis artificial contagious COVID-19 COVID-19 patients COVID-19 virus Data analysis Delay detect Device Efficacy globe identification Infection Intelligent framework Internet life-threatening management medical service network organized outbreak Patient platform quantification radio reduce Registered self Self organized mapping sensitivity Spread statistical supported Surveillance Symptoms Temporal Temporal analysis. virus [DOI] 10.1016/j.artmed.2022.102288 PMC 바로가기
Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso부르키나파소에서 하이드록시클로로퀸 또는 클로로퀸과 아지트로마이신 조합으로 치료한 COVID-19 입원 환자 및 외래 환자의 회복 시간, 악화 및 사망 평가Observational Study Published on 2022-05-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 95% CI adjusted aggravation assessment association Azithromycin Burkina Faso Chloroquine Chloroquine phosphate clearance death disease dose fatality Follow-up Hydroxychloroquine hydroxychloroquine plus azithromycin information Inpatient Inpatients lower risk multivariable no significant difference no significant differences observational study outcome Outpatient Patient patients with COVID-19 phosphate Poisson model provided receiving retrospective SRAS-CoV-2 statistical time Time to recovery treated Treatment viral clearance Virological with COVID-19 worsening [DOI] 10.1016/j.ijid.2022.02.034 PMC 바로가기 [Article Type] Observational Study