α-Hemolysin-Aided Oligomerization of the Spike Protein RBD Resulted in Improved Immunogenicity and Neutralization Against SARS-CoV-2 Variants스파이크 단백질 RBD의 α-헤몰리신 보조 올리고머화로 SARS-CoV-2 변이체에 대한 면역원성 및 중화가 개선됨Immunology Published on 2021-09-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Against alum alum adjuvant Antigen carrier protein Cellular immune response comparable confirmed COVID-19 case conformational conformational epitopes COVID-19 COVID-19 cases cross-protective demonstrated effective Epitopes immunization immunogenicity Improved increase in indicated kDa linear epitopes mHla-RBD molecular weight monomer neutralization activity Neutralizing activity Neutralizing antibodies neutralizing antibody oligomerization Protein pseudovirus Pseudovirus neutralization assay RBD RBD-specific antibodies RBD-specific antibody Safe SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants significantly increased specific antibodies Spike protein Subunit vaccine Th2 the RBD the Spike the spike protein Vaccine development Vaccines wild-type virus [DOI] 10.3389/fimmu.2021.757691 PMC 바로가기 [Article Type] Immunology
Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice조작된 SARS-CoV-2 수용체 결합 도메인은 효모의 제조 가능성과 마우스의 면역원성을 향상시킵니다.403 Published on 2021-09-212022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단, [키워드] ACE2 Antigen approved binding binding domain Candidates Cell country COVID-19 COVID-19 pandemic domain dose doses exhibit exhibited hamster hamsters high-affinity binding immune response immunogenicity IMPROVE Intervention limit manufacturability mice microbial MOST other diseases Pichia pastoris presentation Protein protein vaccine raise raised RBD Receptor-binding domain Recombinant protein recombinant proteins reduced reported Safe SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 variant sequence sequences Significance single dose Subunit vaccine subunit vaccines the RBD the receptor-binding domain the SARS-CoV-2 Vaccine vaccine candidate Vaccines variant Viral viral challenge viral entry virus VLP Volume weight loss Wuhan-Hu-1 yeast [DOI] 10.1073/pnas.2106845118 PMC 바로가기 [Article Type] 403
Plant-Based COVID-19 Vaccines: Current Status, Design, and Development Strategies of Candidate VaccinesReview Published on 2021-09-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Nicotiana benthamaiana affected approach candidate Candidates clinical trial clinical trials convalescent coronavirus coronavirus disease COVID-19 COVID-19 vaccine COVID-19 vaccine development CoVLP CoVLP vaccine current demonstrated development diagnosing Ebola effective Effective vaccines Efficacy effort encapsulate Gaucher Disease glycoengineering immunization infectious disease outbreak Interim monoclonal antibody Neutralizing antibody response outbreak pandemic plant-based vaccine plants plasma preclinical study Prevalence RBD Safe SARS-CoV-2 SARS-CoV-2 variant Spike protein Spread status Strategy Subunit vaccine the vaccine transmission rate VLP ZMapp [DOI] 10.3390/vaccines9090992 PMC 바로가기 [Article Type] Review
Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaquesCD40을 발현하는 세포에 대한 SARS-COV-2 수용체-결합 도메인을 표적으로하는 것은 회복기 원숭이의 감염에 대한 보호를 향상시킨다.Article Published on 2021-09-012022-08-31 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] adjuvant animal models antibody antigen-presenting cells approach approved B cells B1.351 boost CD40 Cell children convalescent Coverage cross-neutralize D614G domain expressing High-dose humanized IMPROVE individuals induce Infection injected long-term memory macaque Marlin memory mRNA vaccines Neutralizing antibodies neutralizing antibody NHPs non-human primate Phenotypes Preclinical research pregnant women Protein vaccines rapid increase RBD Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants significant level significantly single dose Spike protein Subunit vaccine subunit vaccines T and B cells targeting the receptor-binding domain the SARS-CoV-2 vaccination Vaccine Viral Viral antigen viral antigens viral infection Viral vector viral vector and mRNA vaccines virulent [DOI] 10.1038/s41467-021-25382-0 PMC 바로가기 [Article Type] Article
A review of combination adjuvants for malaria vaccines: a promising approach for vaccine developmentarticle Published on 2021-08-312024-09-01 Journal: International Journal for Parasitology [Category] 말라리아, [키워드] Adjuvant system Combination adjuvants immune response malaria Plasmodium Subunit vaccine [Article Type] article
COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective ImmunityArticle Published on 2021-08-272022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome adjuvant adjuvants agonist angiotensin-converting enzyme 2 antibody Cell Cell-mediated immunity Cellular immune response cellular immune responses Combination coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccine Critical Diseases domain effective Efficacy elicited ELISA assays ENhance ferret model Health humoral IFN-γ-producing T cell IFN-γ immune responses magnitude mucosal immunity NAb nasal neutralizing antibody producing promote protective immunity RBD resulting robust SARS-CoV-2 SARS-CoV-2 antigen stimulated subunit Subunit vaccine TLR agonist TLR agonists TLR3 Toll-like receptor Vaccine vaccine platform Viral load [DOI] 10.3390/vaccines9090957 PMC 바로가기 [Article Type] Article
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice다량체화된 SARS-CoV-2 수용체 결합 도메인(RBD)을 사용한 단일 용량 면역은 마우스에서 강화된 보호 반응을 유도합니다Research Letter Published on 2021-08-222022-09-12 Journal: Febs Letters [Category] MERS, 진단, [키워드] Analysis Antibody titre Antigen antigens Bacteria buffer caused complexes coronavirus COVID‐19 COVID‐19 defined demonstrated Dps elicited exclusion experiment expressed form health emergency highlight immunisation increase induce introduced lung mammalian cells mice Microscopy monomeric RBD neutralising antibody pandemic Particle PBS preparation Protective purified Quality control RBD Receptor binding domain SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 SDS spike Subunit vaccine triggered Vaccine viral clearance were expressed [DOI] 10.1002/1873-3468.14171 PMC 바로가기 [Article Type] Research Letter
Cell-Free Glycoengineering of the Recombinant SARS-CoV-2 Spike GlycoproteinBioengineering and Biotechnology Published on 2021-08-162022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] Antigen approach can be used Cell cell-free synthetic biology COVID- 19 E. coli Efficacy expressed expression generate glycan glycoengineering glycosylation Immunity IMPROVE In-vitro insect cells investigated mammalian N -glycosylation Particle Preclinical Testing Protein Protein subunit vaccines recombinant Recombinant protein Research SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike glycoprotein spike spike glycoprotein Subunit vaccine the SARS-CoV-2 the spike protein Trial Vaccine vaccine candidate vaccine candidates variant viral glycoprotein virus [DOI] 10.3389/fbioe.2021.699025 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunizationResearch Article Published on 2021-07-282022-10-28 Journal: Science Advances [Category] Coronavirus, SARS, [키워드] antibodies antibody approach Critical degrade driven by elicit elicited epitope epitope mapping Epitopes glycoprotein HIV immunization immunogen Influenza iterative Microscopy Neutralizing Neutralizing antibodies neutralizing antibody polyclonal prefusion conformation Protein protein subunit vaccine provide responses RSV SARS-CoV-2 subunit Subunit vaccine target trimer trimeric Vaccine Vaccine design variety viral surface virus while [DOI] 10.1126/sciadv.abh2791 PMC 바로가기 [Article Type] Research Article
Biomaterials and Oxygen Join Forces to Shape the Immune Response and Boost COVID‐19 Vaccines생체 재료 및 산소 결합 힘을 결합하여 면역 반응을 형성하고 Covid -19 백신을 향상시킵니다.Research Article Published on 2021-07-202022-08-31 Journal: Advanced Science [Category] SARS, 치료제, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive immune system antibody Antibody titer Antibody titers antigens approach Arm binding biomaterial boost coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 CpG Critical demonstrated Diseases dose effective effective vaccine Effective vaccines Effectiveness Emerging infectious diseases Engineering force generate GM‐CSF Health Health crisis immune response immune stimulation immunization immunized immunogenicity immunological immunomodulatory immunostimulation Infectious diseases injectable cryogel lack mice Neutralizing antibodies neutralizing antibody nucleocapsid offer overcome oxygen platform preclinical studies protective antibodies Protein Protein subunit vaccines RBD receptor‐binding domain reported required respiratory response resulting robust SARS‐CoV‐2 SARS‐CoV‐2 protein second dose severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccine shape Subunit vaccine subunit vaccines sustained Th1 Th2 Vaccine virus [DOI] 10.1002/advs.202100316 PMC 바로가기 [Article Type] Research Article