targeted therapy – Page 10 – Communicable Diseases Research

Analysis of COVID-19 on Diagnosis, Vaccine, Treatment, and Pathogenesis with Clinical Scenarios

Case Report

Published on 2021-05-192022-10-31
Journal: Clinics and Practice [Category] COVID-19,

Identify. Quantify. Predict. Why Immunologists Should Widely Use Molecular Imaging for Coronavirus Disease 2019

식별하다. 정량화. 예측하다. 면역학자들이 코로나바이러스 질병 2019에 대해 분자 영상을 널리 사용해야 하는 이유

Review

Published on 2021-05-132022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

Does systemic anti-tumor therapy increase COVID-19 risk in patients with cancer?

Original Articles

Published on 2021-05-072022-10-29
Journal: Journal of Oncology Pharmacy Practice [Category] COVID-19, SARS,

[키워드] Affect age anticancer antineoplastic agents Cancer cancer patient cancer treatment Chemotherapy COVID COVID-19 COVID-19 infected patient COVID-19 infection COVID-19 pandemic demographic characteristics determine diagnosis of cancer disease Factor hospital Hospitalization Immunotherapy infected patient infection rate lung cancer male material metastatic stage morbidity and mortality non-infected parameter Patient patients patients treated Patients with cancer Prognosis receiving Result risk statistically significant targeted therapy the median the patient Therapies therapy Treatment were infected with COVID-19
[DOI] 10.1177/10781552211015762 PMC 바로가기 [Article Type] Original Articles

Evidence of a putative glycosaminoglycan binding site on the glycosylated SARS-CoV-2 spike protein N-terminal domain

Research Article

Published on 2021-05-042022-10-31
Journal: Computational and Structural Biotechnology Journal [Category] COVID-19,

[키워드] Abstract ACE2 African angiotensin-converting enzyme-2 assist bind binding binding site bioinformatics Cell coronavirus Cosolvent MD simulations COVID-19 docking study evidence of favor furin cleavage site glycosylated glycosylation heparan sulfate heparin identify include infect initial interact MD simulation Molecular dynamics simulation mutated Mutation N-terminal domain novel NTD performed Protein RBD receptor reported residue SARS-CoV-2 SARS-CoV-2 spike protein South Spike protein spike trimer Spread Strains structures subsequent supported targeted therapy the receptor-binding domain the spike protein virus
[DOI] 10.1016/j.csbj.2021.05.002 PMC 바로가기 [Article Type] Research Article

Biological responses to COVID-19: Insights from physiological and blood biomarker profiles

COVID-19에 대한 생물학적 반응: 생리학적 및 혈액 바이오마커 프로필에서 얻은 통찰력

Article

Published on 2021-05-012022-08-31
Journal: Current research in translational medicine [Category] MERS, SARS, 바이오마커,

[키워드] accompanied Admission adverse outcomes Analysis baseline best Biological biological response biological responses Biomarker Biomarkers Blood C-reactive protein Characteristics class Classes collected Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 Course COVID-19 CRP death declined elevated empirical evidence Evidence except for exhibited FIVE heterogeneous highest hospitalised Hyperinflammatory Hyperinflammatory response Implications Inflammation Inflammatory Inflammatory response insight intensive care kidney Kidney injury laboratory-confirmed Laboratory-confirmed COVID-19 Latent latent profile analysis lowest male measure median age mortality rate mortality risk neutrophil neutrophil counts older patients pathophysiology Patient performed physiological Platelet Platelet count profile provide provided renal renal failure response retrospective cohort study rising SARS-CoV-2 severe COVID-19 Spectrum targeted therapy therapeutic understanding unique was performed white cell
[DOI] 10.1016/j.retram.2021.103276 PMC 바로가기 [Article Type] Article

Identification of Distinct Immunophenotypes in Critically Ill Coronavirus Disease 2019 Patients

중환자 코로나바이러스 질환 2019 환자에서 뚜렷한 면역표현형 식별

Article

Published on 2021-05-012022-08-31
Journal: Chest [Category] MERS, SARS, 바이오마커,

[키워드] Activation Acute respiratory failure cause CD4+ CD8+ clinical trial Cluster Clustering complement Complement activation conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical Critical care Critically ill critically ill COVID-19 patients cytokine cytokine level cytokine release elevated eligibility endothelial enrolled evaluated exaggerated inflammatory response exhibiting favor feature France group heterogeneous Hierarchical hierarchical clustering Hypogammaglobulinemia ICU ICU admission identification IL-1β IL-6 IL-8 Ill immunodeficiency immunologically immunology immunophenotype Infection Inflammation inflammatory reaction lung damage marker mediators moderate multi-organ dysfunction Necrosis outcomes Patient patient identification patients phenotype predominant principal components principal components analysis Profiling Prospective Study respiratory Respiratory failure response to therapies SARS-CoV-2 SARS-COV-2 infection SC5b-9 Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 severe COVID-19 severity shown single-center targeted therapy therapeutic therapy Trajectories tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variability variable
[DOI] 10.1016/j.chest.2020.11.049 PMC 바로가기 [Article Type] Article

Giloy Ghanvati ( Tinospora cordifolia (Willd.) Hook. f. and Thomson) Reversed SARS-CoV-2 Viral Spike-Protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish

Pharmacology

Published on 2021-04-192022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] A549 artificial ventilation ayurved Ayurveda caused changes in comparable correlated cough disease disease phenotype distress dosage epithelial cell feature Fever giloy ghanvati granulocyte healthcare Hook human lung humanized Immune cell induced Infection infiltration inflamation Inflammation lack Macrophage Model phenotype pro-inflammatory renal tissue reported respiratory reversed SARS-CoV-2 SARS–CoV–2 spike-protein swim bladder symptomatic systemic damage targeted therapy the disease the SARS-CoV-2 therapy tinopsora cordifolia Traditional Treatment treatment group viral disease were given xenotranplantation zebrafish
[DOI] 10.3389/fphar.2021.635510 PMC 바로가기 [Article Type] Pharmacology

GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals

GSK-3β는 MIA-PaCa-2 췌장암 세포와 MCF-7 유방암 세포의 화학요법 약물, 표적 치료제 및 영양소에 대한 민감성을 조절할 수 있다.

Article

Published on 2021-04-062024-08-08
Journal: Cells [Category] 말라리아,

[키워드] BCl2 Breast cancer chemotherapeutic drugs GSK-3β KRAS nutraceuticals PDAC targeted therapy β-catenin
[DOI] 10.3390/cells10040816 PMC 바로가기 [Article Type] Article

Primary Immune Regulatory Disorders and Targeted Therapies

Review

Published on 2021-03-252024-09-02
Journal: Turkish Journal of Hematology [Category] 대상포진,

[키워드] Autoimmunity immune dysregulation lymphoproliferation precision medicine primary immune deficiencies targeted therapy
[DOI] 10.4274/tjh.galenos.2021.2020.0724 PMC 바로가기 [Article Type] Review

Inferring microenvironmental regulation of gene expression from single-cell RNA sequencing data using scMLnet with an application to COVID-19

코로나19에 적용한 scMLnet을 사용하여 단일 세포 RNA 시퀀싱 데이터에서 유전자 발현의 미세 환경 조절 추론

Article

Published on 2021-03-222022-09-11
Journal: Briefings in Bioinformatics [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 expression activated addition anti-cytokine therapies anti-cytokine therapy applied approach Cell cellular cellular microenvironment correlated COVID-19 COVID-19 infection COVID-19 patient COVID-19 severity cytokine Cytokines dataset EGF expression of SARS-CoV-2 Extracellular facilitate functional Gene Expression gene regulatory network human lung cell human lung cells IFN-γ Infection Inflammatory cytokine Inflammatory cytokines Intercellular communication mechanism methodology microenvironment multilayer network predicted provided receptor ACE2 Regulation reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor scMLnet scRNA-seq sequencing data Signaling signaling pathway significantly Single-cell RNA sequencing single-cell RNA-seq Single-cell RNA-sequencing targeted therapy TNF-α
[DOI] 10.1093/bib/bbaa327 PMC 바로가기 [Article Type] Article