Next-Generation “-omics” Approaches Reveal a Massive Alteration of Host RNA Metabolism during Bacteriophage Infection of Pseudomonas aeruginosa차세대 "-omics" 접근 방식으로 녹농균(Pseudomonas aeruginosa)의 박테리오파지 감염 동안 숙주 RNA 대사의 대규모 변경이 밝혀짐Research Article Published on 2016-07-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] alteration Analysis approaches Bacteria Bacterial bacterial strains bacteriophage bacteriophages block changes in characterized coding Complete Course Degradation demonstrated drastic early stage Escherichia coli expressed family Gene Expression generate highlight Host infecting Infection infection cycle infection cycles Interaction interfere involved knowledge lifecycle massive metabolic pathway metabolic pathways metabolism metabolomics molecular molecular mechanism molecular mechanisms multidrug resistant nucleotide opportunistic pathogen pathogen produced promote proportion Pseudomonas aeruginosa pyrimidine Regulation required RNA RNA-sequencing RNAs shown stimulate strain suggested therapeutic therapeutic potential therapy transcript transcriptomics treat Trigger triggers Viral viral replication Viral RNA viral RNAs virulent virulent phage virus viruses [DOI] 10.1371/journal.pgen.1006134 PMC 바로가기 [Article Type] Research Article
The Nuclear Immune Receptor RPS4 Is Required for RRS1 SLH1 -Dependent Constitutive Defense Activation in Arabidopsis thaliana핵 면역 수용체 RPS4는 Arabidopsis thaliana에서 RRS1 SLH1 -의존적 구성 방어 활성화에 필요합니다Research Article Published on 2014-10-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activate Activation Agrobacterium allele Amino acid analysis Arabidopsis Arabidopsis thaliana Bacterial C-terminal Cell complex conducted Defense disease DNA binding domain dominant downstream effector effectors ENCODE function Genes Genetic genetic screen growth hypotheses identify Immune receptor immune receptors immune responses Immunity inactive insertion leucine loss-of-function mutation loss-of-function mutations mammalian mechanism motif mutant mutants Mutation NLR NLRs nuclear nucleotide overlap pathogen performed plant plants Protein Pseudomona Pseudomonas R genes receptor Recognition recognize required rescued responses RRS1 secretion Signaling significantly temperature transcribed transcriptional transcriptional activation transcriptional change Trigger triggers type III wild type [DOI] 10.1371/journal.pgen.1004655 PMC 바로가기 [Article Type] Research Article
Gene Set Signature of Reversal Reaction Type I in Leprosy Patients나병 환자의 역전 반응 유형 I의 유전자 세트 서명Research Article Published on 2013-07-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major accurate Affect affected Analysis Anti-inflammation anti-inflammatory mediator anti-inflammatory mediators Antigen antigens arachidonic acid Author Blood conducted Critical cured defined Definition diagnosed Diagnosis different differential expression differentially regulated genes Endemic enrolled environmental factor environmental factors evaluated Factor functional Gene genes encoding Genetic genetic background genetic profile Genome healthy individual healthy individuals immune incidence increased risk Inflammatory response Innate immunity leprosy majority mediators metabolism Mycobacterium leprae nerve damage Pathogenesis Patient performed Predictive pro-inflammatory Prospective Study reaction reflect Regulation replicated retrospective Retrospective study reversal reversal reactions RNA sample RNA samples signature Stimulation subsequent subset Transcriptome Trigger triggers Type validation Validity Whole blood [DOI] 10.1371/journal.pgen.1003624 PMC 바로가기 [Article Type] Research Article
Principles of Carbon Catabolite Repression in the Rice Blast Fungus: Tps1, Nmr1-3, and a MATE–Family Pump Regulate Glucose Metabolism during Infection쌀 돌풍 곰팡이의 탄소 이화 작용 억제 원리: Tps1, Nmr1-3 및 MATE-Family 펌프가 감염 중 포도당 대사를 조절합니다Research Article Published on 2012-05-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abolishes disease addition Agrobacterium tumefacien Agrobacterium tumefaciens Analysis Author BLAST carbon Carbon catabolite repression carbon metabolism carbon sources Catabolite catabolite repression CCR cell wall cell wall–degrading enzymes component components described disease downstream effective expression filamentous fungi found functional fungal fungal pathogens fungi Genetic genetic regulation Glucose glucose metabolism Glucose-6-phosphate Host identify inactivation Infection infection process inhibitor involved less M. oryzae Magnaporthe MATE protein MATE–family protein Mdt1 mechanism mediators metabolism microbial Mutagenesis Nmr1 Nmr1-3 Nmr1-3 inhibitor proteins nutrient availability organism Pathogenesis pathogenic pathogenicity Pathogens pathway Perturbation physiological principle Protein pump regulate Regulation Regulatory regulatory pathway regulatory pathways repression respond Rice shown sporulation strain sugar target Tps1 transcription factor transcriptional transmembrane Trigger triggers understanding [DOI] 10.1371/journal.pgen.1002673 PMC 바로가기 [Article Type] Research Article
Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion CompetenceReview Published on 2012-04-122022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] activate angiotensin converting enzyme 2 antiviral therapies Carcinoembryonic antigen cathepsin cofactor competence coronavirus Coronavirus infection endocytosis Endosomes fusion highlight Interaction interactions membrane fusion other protease protease Proteins receptor response S protein S proteins spike Spike protein transmembrane protease transmembrane serine protease triggers TTSPs viral pathogenesis viral spike virus virus entry virus-cell membrane fusion [DOI] 10.3390/v4040557 PMC 바로가기 [Article Type] Review
MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic StressMK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다Research Article Published on 2011-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream [DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article