A Journey From SARS-CoV-2 to COVID-19 and Beyond: A Comprehensive Insight of Epidemiology, Diagnosis, Pathogenesis, and Overview of the Progress into Its Therapeutic ManagementPharmacology Published on 2021-02-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV acute respiratory illness acute respiratory syndrome addition affected age Antiviral approval approved Azithromycin cause China clinical trial Comprehensive conducted contagious coronavirus coronavirus disease country COVID-19 death Dexamethasone disease healthy Hydroxychloroquine immunosuppressed patients Inhaled insight medical condition nitric oxide oxygen pandemic pregnant women preventive measure Progress reduce Remdesivir SARS-CoV-2 significantly specific treatment Spread the disease the vaccine Transmission Treatment Trial Vaccine Vaccines Ventilated WHO Wuhan [DOI] 10.3389/fphar.2021.576448 PMC 바로가기 [Article Type] Pharmacology
Helicopter transport of critical care COVID-19 patients in the Netherlands: protection against COVID-19 exposure-a challenge to critical care retrieval personnel in a novel operationObservational Study Published on 2021-02-262022-10-04 Journal: Scandinavian Journal of Trauma, Resuscitation and [Category] MERS, 임상, [키워드] aeromedical applied asked blood sample calculate contagious Contagious patients COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptoms Critical care Emergency Environment Evidence examined exceeded exposure feasible Helicopter Helicopter emergency medical service HEMS IgG IgG antibody Initially initiated intensive care MONITOR Netherlands occupational outbreak Patient performed Personal protective equipment Personnel protection equipment Pneumonia positive PPE reported Result Retrieval personnel retrospective Safe SARS-CoV-2 serology testing service Support tested the patient Transport transported Ventilated were used [DOI] 10.1186/s13049-021-00845-x PMC 바로가기 [Article Type] Observational Study
Intracerebral Hemorrhage in COVID-19 Patients with Pulmonary Failure: A Propensity Score-Matched Registry StudyObservational Study Published on 2021-02-232022-10-04 Journal: Neurocritical care [Category] MERS, 임상, [키워드] acute respiratory distress age antiplatelet ARDS ARDS patients bleeding Case report cause conducted confounders COVID-19 COVID-19 group COVID-19 patient COVID-19 patients exhibited extracorporeal membrane oxygenation group hemorrhage ICH ICU in both group Intracerebral hemorrhage male no statistical difference non-COVID-19 group Older Patient patients with ARDS patients with moderate PCR-positive SARS-CoV-2 Propensity score pulmonary registry required Result retrospective risk SARS-CoV-2 severe ARDS significantly more single-center study SOFA score statistically supplementary material survival syndrome systemic anticoagulation therapeutic anticoagulation therapy thrombosis Ventilated VV-ECMO was performed [DOI] 10.1007/s12028-021-01202-7 PMC 바로가기 [Article Type] Observational Study
Efficacy and safety of systematic corticosteroids among severe COVID-19 patients: a systematic review and meta-analysis of randomized controlled trials중증 코로나19 환자를 대상으로 한 전신 코르티코스테로이드의 효능 및 안전성: 무작위 대조 시험에 대한 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-02-212022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, MERS, 임상, [키워드] 95% confidence interval all-cause mortality Analysis applied approach assessment benefit calculate certainty CIs Controlled controlled trials coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 therapy death development Disease progression Enrollment evaluate evaluated Evidence excluded extracorporeal membrane oxygenation Follow-up ICU identify Immunotherapy incidence Infectious diseases intubation Meta-analysis not increased Occurrence outcome Patient Primary outcome progression random-effects model Randomized controlled trial Randomized controlled trials RCT RCTs recovery RECOVERY trial required Result risk risk ratio searched secondary Secondary outcomes sequential analysis Serious Adverse Event Serious Adverse Events severe coronavirus disease severe COVID-19 severe COVID-19 patients subjects suggested survival systematic corticosteroid systematic review transfer Trial trial sequential analysis Ventilated Ventilation [DOI] 10.1038/s41392-021-00521-7 PMC 바로가기 [Article Type] Meta-Analysis
Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation기계적 환기가 필요한 환자에서 나이가 들수록 안지오텐신 전환 효소 2(ACE2) 발현이 증가합니다.Research Article Published on 2021-02-162022-09-10 Journal: PLoS ONE [Category] MERS, 유전자 메커니즘, [키워드] ACE2 ACE2 distribution ACE2 expression ACE2 protein ACE2 receptor acute hypoxic respiratory failure advanced age Affect affecting age AHRF alveolar damage Alveolar macrophages Alveolar Type II AT2 Cell cells cellularity change Cohort collected contribute Critical Diffuse alveolar damage enzyme Examining expression feature histologic hospital Host human lung hypoxic respiratory failure IHC immunohistochemistry increase individuals Infection investigated Lower respiratory tract lower respiratory tract infection lung macrophages mechanical ventilation Mortality normalized on mechanical ventilation parameter Patient phenotypic potential mechanism profile protein expression reactive receiving respiratory Respiratory failure RNA RNA sequencing data SARS-CoV-2 selected specimen tissues Type II pneumocyte type II pneumocytes upregulated Ventilated Ventilation [DOI] 10.1371/journal.pone.0247060 PMC 바로가기 [Article Type] Research Article
Multistate Modeling of COVID-19 Patients Using a Large Multicentric Prospective Cohort of Critically Ill PatientsArticle Published on 2021-02-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress disease Admission analyzed approach Corticosteroid COVID-19 COVID-19 patient COVID-19 patients Critically ill database dependent on drug Effect evaluate evaluated extracorporeal membrane oxygenation French hazard ratio ICU ICU admission Ill include intensive care intensive unit care intubation Invasive mechanical ventilation modeling Mortality non-invasive ventilation outcome Patient predicted Probability Prognostic factors Prospective risk survival syndrome Tocilizumab Ventilated Ventilation [DOI] 10.3390/jcm10030544 PMC 바로가기 [Article Type] Article
Mobility Patterns During COVID-19 Travel Restrictions in Nairobi Urban Informal Settlements: Who Is Leaving Home and WhyArticle Published on 2021-02-022022-10-30 Journal: Journal of Urban Health : Bulletin of the New York [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval adjusted conducted contributing to COVID-19 COVID-19 infection COVID-19 mitigation measures Critical decrease employment Factor female FIVE higher risk home increase individual less lockdown maintain majority Mask Masks measure men Mobility multinomial regression novel coronavirus disease pattern Prevent PROTECT reduced reported restriction resulting Spread step Travel urban Ventilated women worker [DOI] 10.1007/s11524-020-00507-w PMC 바로가기 [Article Type] Article
Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort studyObservational Study Published on 2021-02-012022-10-04 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, MERS, 임상, [키워드] 28-day mortality age applied arterial pH center Clinical outcome Combination Compliance complications country COVID-19 died driving eligible Gender help Hospital stay hypothese hypoxaemia ICU ICUs intensive care unit Interpretation invasive ventilation invasively ventilated patient IQR lung-protective ventilation management median Mortality multicentre National Netherlands Observational cohort study outbreak outcome parameter Patient patients patients with COVID-19 PEEP Positive end-expiratory pressure predicted Primary outcome prone positioning Registered Respiratory system retrospective sample size calculation secondary Treatment Trial university variable Ventilated Ventilation ventilator ventilator-free day Volume with COVID-19 [DOI] 10.1016/S2213-2600(20)30459-8 PMC 바로가기 [Article Type] Observational Study
Evaluation of patient characteristics, management and outcomes for COVID-19 at district hospitals in the Western Cape, South Africa: descriptive observational studyObservational Study Published on 2021-01-262022-10-04 Journal: BMJ Open [Category] 임상, [키워드] 95% CI ACCIDENT & age assessment Asthma Cape Care Characteristics Chronic kidney disease chronic obstructive Clinical management clinical outcomes clinical picture Comorbidities Comorbidity comparable COVID-19 cross-sectional demographics discharged home disease District emergency medicine Factor females HIV hospital hospitals hypertension increased mortality Increasing Intubated IQR Laboratory Lung disease majority male management median Mild moderate Mortality MOST Most patient outcome oxygen Patient patients with COVID-19 Physicians positive presenting symptoms primary care pulmonary pulmonary disease reported respiratory infections risk factor Rural health secondary outcome significantly Source South South Africa supported Test tested transferred treated Treatment Tuberculosis type 2 diabete Ventilated [DOI] 10.1136/bmjopen-2020-047016 PMC 바로가기 [Article Type] Observational Study
Evolution of spray and aerosol from respiratory releases: theoretical estimates for insight on viral transmission1006 Published on 2021-01-202022-10-29 Journal: Proceedings. Mathematical, Physical, and Engineering Sciences [Category] COVID-19, [키워드] absence affected change controls cough COVID-19 defined distribution dose droplet estimate Evolution Infection infection risk initial viral load performed physical distancing Quantitative Release required respiratory releases resulting SARS-CoV-2 viral load significantly Ventilated Ventilation Viral transmission [DOI] 10.1098/rspa.2020.0584 PMC 바로가기 [Article Type] 1006