1 H, 13 C, and 15 N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10Article Published on 2020-11-072022-10-27 Journal: Biomolecular Nmr Assignments [Category] COVID-19, [키워드] backbone Coronavirus-2 COVID19-NMR drugs element ENCODE function genomic in viral innate immune system Interaction International involved Ligand methyltransferase molecular component NMR non-structural protein nsp14 Nsps PROTECT Protein Proteins Replication replication-transcription complex RNA RNA genome RNA-dependent RNA polymerase RTC SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA Solution NMR-spectroscopy structural proteins Structure subgenomic RNAs transcriptional variety Via viral envelope viral life cycle Viral RNA virus [DOI] 10.1007/s12104-020-09984-1 PMC 바로가기 [Article Type] Article
1 H, 13 C, and 15 N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10Article Published on 2020-11-072022-10-27 Journal: Biomolecular Nmr Assignments [Category] Coronavirus, COVID-19, SARS, [키워드] backbone Coronavirus-2 COVID19-NMR drugs element ENCODE function genomic in viral innate immune system Interaction International involved Ligand methyltransferase molecular component NMR non-structural protein nsp14 Nsps PROTECT Protein Proteins Replication replication-transcription complex RNA RNA genome RNA-dependent RNA polymerase RTC SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA Solution NMR-spectroscopy structural proteins Structure subgenomic RNAs transcriptional variety Via viral envelope viral life cycle Viral RNA virus [DOI] 10.1007/s12104-020-09984-1 PMC 바로가기 [Article Type] Article
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitroArticle Published on 2020-11-042022-10-04 Journal: Cell Discovery [Category] 신약개발, 치료제, [키워드] abrogate Actin approved drug assist bind Cell cell entry characterized COVID-19 Cytopathic effect disrupt drug endocytosis entry pathway facilitate generate genetics glycobiology heparan sulfate in vitro inhibit inhibitor involved mechanism promote reveal SARS Coronavirus SARS-CoV-2 screened spike sunitinib viral entry viral life cycle viral particle [DOI] 10.1038/s41421-020-00222-5 PMC 바로가기 [Article Type] Article
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein functionBioinformatics Published on 2020-10-162022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory disease addition Affect changed changes in Characteristics COVID-19 Critical detect effort Evolution gene encoding genes encoding Genetic genetic code Genome genomes highlight highlighting Host humans identify in viral independent indicate innate immune system molecular Mutation nonsynonymous Novel coronavirus Perspective positive Positive selection Protein Region Result RNA molecules RNA stability SARS-CoV-2 spike synonymous target Test the SARS-CoV-2 genome Transcription translation unique viral life cycle [DOI] 10.7717/peerj.10234 PMC 바로가기 [Article Type] Bioinformatics
Protease Inhibitory Effect of Natural Polyphenolic Compounds on SARS-CoV-2: An In Silico StudyArticle Published on 2020-10-102022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] analyzed anti-protease activity antiviral activity Area AutoDock binding binding affinity caused Compound compounds death drug drug-drug interaction drugs Effect expected Health help host protein in-silico In-vitro Mechanics MM-PBSA molecular docking molecular dynamic simulation MPro natural pandemic parameter performed pharmacokinetic polyphenols post-translational modification predict predicted Preliminary data priming protease reported SARS-CoV-2 SARS-CoV-2 Mpro SARS-CoV-2 virus selected similarity surface target these compound TMPRSS2 TMPRSS2 protein Toxicity viral life cycle Viral protein viral spike protein [DOI] 10.3390/molecules25204604 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and the Possible Role of Raf/MEK/ERK Pathway in Viral Survival: Is This a Potential Therapeutic Strategy for COVID-19?Review Published on 2020-10-022023-07-02 Journal: Pharmacology [Category] SARS, [키워드] COVID-19 Raf/MEK/ERK signaling RNA viruses viral life cycle viral survival [DOI] 10.1159/000511280 PMC 바로가기 [Article Type] Review
Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19Article Published on 2020-10-012022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 임상, 치료법, 치료제, [키워드] absence antiviral activity cardiac disease cardiovascular disease Cell Biology Chloroquine Comorbidity Concentration coronavirus Coronaviruses COVID-19 digoxin Diseases drug Drug discovery effective exacerbated FDA half-maximal inhibitory concentration heart disease hpi hypertension immunology inhibited Microbiology mortality rate pandemic Patient patients with COVID-19 post entry Post-infection Remdesivir SARS-COV-2 infection SARS-CoV-2 replication therapeutic agents therapeutic effect Therapeutic treatment Treatment treatment for COVID-19 viral life cycle virus titer [DOI] 10.1038/s41598-020-72879-7 PMC 바로가기 [Article Type] Article
Coronavirus in human diseases: Mechanisms and advances in clinical treatmentReview Published on 2020-10-012022-10-30 Journal: MedComm [Category] COVID-19, [키워드] 3CLpro accessory protein acute respiratory syndrome Antiviral agents antiviral drug association Cell Clinical treatment clinical treatments coronavirus COVID‐19 COVID‐19 CoVs current disease effective Helicase highlight Human human coronaviruses human diseases infections mechanism MERS Middle East Mild pathogen PLPro Protein provide RdRP RNA virus S protein SARS SARS‐CoV‐2 signaling pathway strain syndrome target therapeutic option Therapeutic strategies Treatment treatment strategy upper respiratory viral life cycle virus [DOI] 10.1002/mco2.26 PMC 바로가기 [Article Type] Review
Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review바이러스 수명 주기의 진입 후 단계를 대상으로 하는 잠재적인 Anti-SARS-CoV-2 치료제: 종합 검토Review Published on 2020-09-262022-09-10 Journal: Viruses [Category] SARS, 비임상, [키워드] (RdRp breath chemical structures clinical investigation clinical trial clinical trials clinically Comprehensive coronavirus coronavirus disease COVID-19 decrease described Dexamethasone dihydroorotate dehydrogenase early stage Effect effective EIDD-2801 facilitate Favipiravir Health care Health care system health care systems identify include Infection life life cycle limit M pro main protease mechanism molecular monoclonal antibodies mortality rate pandemic Papain-like protease pharmaceutical companies polypeptides Potential presenting Prevent protease RdRP Remdesivir Research review RNA-dependent RNA polymerase SARS-CoV-2 scientist severity of COVID-19 Small molecules Stage Structure target Therapeutics Treatment Viral viral infection viral life cycle Viral protein Viral proteins Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.3390/v12101092 PMC 바로가기 [Article Type] Review
Assessment of proton-coupled conformational dynamics of SARS and MERS coronavirus papain-like proteases: Implication for designing broad-spectrum antiviral inhibitorsARTICLES Published on 2020-09-212022-10-30 Journal: The Journal of Chemical Physics [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antiviral drug antiviral inhibitor assessment assist calculated catalytic caused computation conformational coronavirus CoV cysteine cysteine protease drug target Evidence flexible GPU Hypothesis inhibitor lack MERS coronavirus MERS-CoV Middle East modulate molecular Outbreaks pandemic Papain-like protease physiological plasticity PLPro Prevent protonation state residue respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 Simulation starting point structure-based design Support supported viral life cycle [DOI] 10.1063/5.0020458 PMC 바로가기 [Article Type] ARTICLES