Structural Comparison of the SARS CoV 2 Spike Protein Relative to Other Human-Infecting CoronavirusesMedicine Published on 2021-01-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] approach C-terminal domain (CTD) Cluster Contact CoV CoV spike protein CoV spike proteins CoVs generate HCoV 229E HKU1 Host Human Infection Lineage MERS Model modeling N-terminal domain (NTD) NL63 OC43 Other pandemic pattern performed Phylogenetic Protein relative RMSD RNA virus S1 domain S1-NTD SARS coronavirus 2 (SARS2) SARS CoV SARS1 SARS2 selected Seven similarity spike spike glycoprotein Spike protein viral pathogenesis viral surface virulence whole protein [DOI] 10.3389/fmed.2020.594439 PMC 바로가기 [Article Type] Medicine
Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic miceArticle Published on 2021-01-112022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] Activation antiviral cytokine bat bat coronavirus bats Brain Cell cell entry chemokines co-immunoprecipitation coronavirus CoV Cytometry cytopathic effects DDP4 DPP4 Evidence Flow Human human coronavirus in vitro infect inflammatory change intranasal Isolation lung mice overcome Proinflammatory cytokine receptor replicate self-limiting disease target cell Transmission Tylonycteris viral pathogenesis Viral reservoirs virus while [DOI] 10.1038/s41467-020-20458-9 PMC 바로가기 [Article Type] Article
H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infectionH2V: SARS-CoV-2, SARS-CoV, MERS-CoV 감염에 반응하는 인간 유전자 및 단백질 데이터베이스Database Published on 2021-01-072022-09-01 Journal: BMC Bioinformatics [Category] 유전자 메커니즘, 진단, [키워드] accelerate Analysis Antiviral antiviral agent approved article caused cellular and molecular cellular pathway cellular pathways collected confirmed case coronavirus Coronavirus infection Coronavirus infections country CoV infection COVID-19 pandemic database death develop Economy expected Gene highly pathogenic human body human gene human genes identify Impact impair Infection information measure MERS MERS-CoV MERS-CoV infection molecular Novel coronavirus powerful tool Protein proteomic provide public health respond response Result SARS-CoV SARS-CoV-2 Society targets these viruses transcriptomic Treatment Vaccine Viral viral infection viral infections viral pathogenesis viruses WHO [DOI] 10.1186/s12859-020-03935-2 PMC 바로가기 [Article Type] Database
H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infectionDatabase Published on 2021-01-072022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] accelerate Analysis Antiviral approved article caused cellular and molecular cellular pathway collected confirmed case coronavirus Coronavirus infection country COVID-19 pandemic database death develop expected Gene highly pathogenic human gene identify Impact impair Infection information measure MERS-CoV MERS-CoV infection molecular Novel coronavirus powerful tool Protein proteomic provide public health respond response Result SARS-CoV SARS-CoV-2 targets transcriptomic Treatment Vaccine viral infection viral pathogenesis viruses WHO [DOI] 10.1186/s12859-020-03935-2 PMC 바로가기 [Article Type] Database
H2V: a database of human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infectionDatabase Published on 2021-01-072022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, COVID-19, Fulltext, MERS, [키워드] accelerate Analysis Antiviral approved article caused cellular and molecular cellular pathway collected confirmed case coronavirus Coronavirus infection country COVID-19 pandemic database death develop expected Gene highly pathogenic human gene identify Impact impair Infection information measure MERS-CoV MERS-CoV infection molecular Novel coronavirus powerful tool Protein proteomic provide public health respond response Result SARS-CoV SARS-CoV-2 targets transcriptomic Treatment Vaccine viral infection viral pathogenesis viruses WHO [DOI] 10.1186/s12859-020-03935-2 PMC 바로가기 [Article Type] Database
Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2COVID-19 환자의 비인두 샘플 전사체 및 다른 SARS-CoV-2 감염 모델과의 비교 분석은 SARS-CoV-2에 대한 이질적인 숙주 반응을 보여줍니다Comparative Study Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 변종, 유전자 메커니즘, [키워드] ACE2 Analysis Antigen presentation Apoptosis Atf3 CCL2 CCL4 CCR1 COVID-19 COVID-19 patient CXCL2 cytokine cytokine signaling disparate DPP4 effective enrichment analysis exhibited expressed expression feature Functional enrichment analyses GATA6 Genome variations genomic HDAC2 Host host response Host transcriptional response host transcriptome hypoxia IFN IL1A IL6 immune immune response immune system incorporation induction of apoptosis Innate immunity integrin Integrins interferon Invasion isolates ITGA2B ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAE ITGAV ITGB3 ITGB7 lung Lung injury Lungs Missense mutation nasopharyngeal cells nasopharyngeal sample Nasopharyngeal samples NFAT non-structural protein overexpression Pathogenesis patients progression protease reported response Result SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection TCF12 transcription factor transcription factors Transcriptome upregulation Viral viral pathogenesis Viral protein Viral proteins virus [DOI] 10.1186/s12967-020-02695-0 PMC 바로가기 [Article Type] Comparative Study
The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 InfectionArticle Published on 2021-01-022022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, [키워드] ACE2 Brain cell type circulatory system Clinical diagnosis COVID-19 COVID-19 patient develop digestive system enzyme II evaluate Evidence fallopian tube gall bladder help high expression level Human intestine investigated kidney Lungs multiple organ dysfunction nervous system organ other organ other organs patients Profiling proliferation promote provide receptor protein reproductive Respiratory system risk SARS-CoV-2 SARS-COV-2 infection scRNA-seq scRNA-seq data Single-cell RNA sequencing small intestine susceptibility susceptible susceptible organs syndrome TMPRSS2 TMPRSS2 expression TMPRSS2 expression level Transmission Treatment urinary system viral infection viral pathogenesis virus [DOI] 10.3390/ijerph18010284 PMC 바로가기 [Article Type] Article
Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza VirusReview Published on 2020-12-242022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, SARS, [키워드] candidate caused complementary Compound country Critical derivative flavonol flavonols genome structure Government include Infection Influenza Influenza virus medicinal plants Mutation National natural outbreak pandemic plant quercetin quercetin derivatives Respiratory disease respiratory manifestation SASRS-COV-2 shown standard medications Symptom targets tested therapeutic effect therapy treatable Treatment viral pathogenesis [DOI] 10.3390/biom11010010 PMC 바로가기 [Article Type] Review
Loss of orf3b in the circulating SARS-CoV-2 strainsResearch Article Published on 2020-12-242022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] addition Alter amino acids analysed Analysis Betacoronavirus cause caused circulating Complete Continuous country COVID-19 pandemic D614G D614G substitution death ENhance Evolution France full-length functional Genome help human infection Laboratory Loss loss of function nine Non-synonymous notable ORF3a ORF3b prevalent Protein Q57H reached SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 strain SARS-CoV-2 strains Saudi Arabia South Korea stop codon Substitution the interferon Transmissibility Transmission USA viral adaptation viral genome viral pathogenesis viral strain virulence virus [DOI] 10.1080/22221751.2020.1852892 PMC 바로가기 [Article Type] Research Article
Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and UpdateCardiovascular Medicine Published on 2020-12-232022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 25-hydroxyvitamin D acute respiratory disease Affect ambient association benefit Blood cardiometabolic cardiovascular disease collected coronavirus disease Coronavirus-2 COVID-19 diabete dose Effect effective Evidence Factors High dose Immunity Impact individual infection with SARS-CoV-2 Inflammation lack less LIGHT Measures mechanism modulate morbidity and mortality Mortality narrative nitric oxide obesity outcomes pandemic physical activity Potential potential benefit protective mechanisms Radiation reducing Research researcher review Safe SARS-CoV-2 seeking severity sun exposure ultraviolet ultraviolet light UV light vaccination viral pathogenesis Vitamin D Vitamin D supplementation [DOI] 10.3389/fcvm.2020.616527 PMC 바로가기 [Article Type] Cardiovascular Medicine