virion – Page 10 – Communicable Diseases Research

Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity

ACE2 및 NRP1 바이러스 수용체의 후성적 표적화는 SARS-CoV-2 감염성을 제한합니다

Research

Published on 2021-10-112022-09-10
Journal: Clinical Epigenetics [Category] MERS, SARS, 유전자 메커니즘, 치료제,

Improving human coronavirus OC43 (HCoV-OC43) research comparability in studies using HCoV-OC43 as a surrogate for SARS-CoV-2

Article

Published on 2021-10-092022-10-04
Journal: Journal of virological methods [Category] MERS, SARS, 치료기술, 치료제,

[키워드] accompany acute respiratory syndrome added African green monkey analyzed antibodies antibody concentration approach biosafety BSL-3 Cell cell line cells Colon cancer Combination common cold comparability complicate conducted coronavirus counter CPE Culture Cytopathic effect days post infection demonstrated described droplet fibroblast Flow virometry growth Growth Curve HCoV-OC43 human coronavirus human coronavirus OC43 human lung Improving Infection infectious dose investigated kidney less multiplicity of infection pandemic parameter Plaque assay produced quantification quantified reached reducing reproducibility required Research respiratory aerosol Respiratory system Sample SARS-CoV-2 Sartorius Seven Standardization target TCID these cell tissue transmitted Vero E6 Vero E6 cell virion virus particle Virus titration
[DOI] 10.1016/j.jviromet.2021.114317 PMC 바로가기 [Article Type] Article

SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathway

Original Article

Published on 2021-10-082022-10-30
Journal: MedComm [Category] COVID-19,

Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage Interactions

SARS-CoV-2-인간 대식세포 상호작용에 대한 타고난 면역 반응 정의

Immunology

Published on 2021-10-042022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation activity acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ARDS characterized chemokine component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dendritic cells dysregulation end-organ end-organ disease Evidence evidence of expression Host human monocyte human monocyte-derived macrophages IFN immune Infection Inflammation Inflammatory Innate innate immune innate immune response Interaction interferon investigated life-threatening coronavirus disease Macrophage macrophages malfunctions monocyte-macrophage Monocytes mononuclear phagocyte mononuclear phagocytes morbidities pro-inflammatory pro-inflammatory cytokine profile proteomic proteomics receptor respiratory respiratory distress Respiratory distress syndrome response robust SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus signaling pathways syndrome systemic inflammation the SARS-CoV-2 tissue damage transcriptomic transcriptomics type I interferon Viral viral infection viral replication virion virions while
[DOI] 10.3389/fimmu.2021.741502 PMC 바로가기 [Article Type] Immunology

Precursors of Viral Proteases as Distinct Drug Targets

Review

Published on 2021-10-022022-10-28
Journal: Viruses [Category] COVID-19, SARS,

Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation

강력한 C형 간염 바이러스 프로테아제 억제제인 Asunaprevir, SARS-CoV-2 전파 차단

Article

Published on 2021-09-302022-09-11
Journal: Molecules and cells [Category] SARS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity asunaprevir binding block blocked calu-3 cells candidate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytopathic effect cytopathic effects daclatasvir direct-acting antiviral Drug repurposing evaluated Health hepatitis C hepatitis C virus human lung human lung Calu-3 cells include infected cells inhibited inhibitor life cycle NS5A pandemic potent Propagation Protease inhibitor protein level protein levels RNA RNA polymerase inhibitor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 vaccine SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus significantly sofosbuvir therapeutic agent Treatment vaccination Vero E6 VERO E6 cells viral life cycle virion
[DOI] 10.14348/molcells.2021.0076 PMC 바로가기 [Article Type] Article

Development of the Inactivated QazCovid-in Vaccine: Protective Efficacy of the Vaccine in Syrian Hamsters

Microbiology

Published on 2021-09-272022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] aluminum antibody Antigen body temperature buffer candidate vaccine clinical symptom coronavirus disease COVID-19 Culture develop development dose Effectiveness filtration formaldehyde gel hamster hamsters homologous hydroxide inactivated Inactivated vaccine indicated Infection Kazakhstan log lung observation period Particles patients Pneumonia Protective protective efficacy purified QazCovid-in Registered replicative retained saline solution SARS-CoV-2 Stress survival Syrian hamsters TCID the SARS-CoV-2 virus the vaccine trials Vaccine Vero Cell viral replication virion virulent virus virus-neutralizing antibody was used were used
[DOI] 10.3389/fmicb.2021.720437 PMC 바로가기 [Article Type] Microbiology

SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1

SARS-COV-2 재조합 수용체 결합 도메인(RBD)은 SARS-CoV-2 및 SARS-CoV-1의 변이주에 대한 중화 항체를 유도합니다

Article

Published on 2021-09-242022-09-11
Journal: Vaccine [Category] MERS, SARS, 변종, 진단,

Analysing the impact of the two most common SARS-CoV-2 nucleocapsid protein variants on interactions with membrane protein in silico

Short Communications

Published on 2021-09-202022-10-30
Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19,

Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with Remdesivir

Article

Published on 2021-09-162022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] activity anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral drug biogenesis calpeptin calu-3 cells clinical study Combination coronavirus disease COVID-19 cysteine cytotoxicity demonstrated dose-dependent inhibition drug Effect EVs exhibited expression extracellular vesicle Extracellular vesicles half-maximal inhibitory concentration Health IC50 Impact infected cell inhibited inhibitor inhibitors monotherapy pandemic pathway proteinase release mechanism Remdesivir SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 viral replication screened Screening significantly small molecule inhibitor therapeutic efficacy validation Vero E6 cell VERO-E6 virion virus
[DOI] 10.3390/biomedicines9091230 PMC 바로가기 [Article Type] Article