Gene Variants Related to Cardiovascular and Pulmonary Diseases May Correlate with Severe Outcome of COVID-19심혈관 및 폐 질환과 관련된 유전자 변이가 COVID-19의 심각한 결과와 관련될 수 있음Article Published on 2022-08-042022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Analysis association cardiovascular cardiovascular diseases Cohort collected correlated COVID-19 COVID-19 patients CVD DRC1 Genetic Genetic variant genetic variants GWAS HADHA identified variant INDEL individual introns nucleotide outcome Poland polymorphism Protective pulmonary pulmonary disease pulmonary diseases risk Risk factors single nucleotide Single nucleotide polymorphism SNP SNPs subset variant variants was performed was used WGS whole-genome sequencing [DOI] 10.3390/ijms23158696 PMC 바로가기 [Article Type] Article
Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds단쇄 및 쌍쇄 4차 암모늄 화합물에 의한 항생제 내성의 분자 메커니즘Article Published on 2022-08-012022-09-11 Journal: The Science of the total environment [Category] 유전자 메커니즘, [키워드] accelerated Ammonium Antibiotic resistance Antibiotics BAC benzalkonium Benzalkonium chloride Cell chloride Compound Concentration contributed COVID-19 pandemic DDAC Didecyldimethylammonium Didecyldimethylammonium chloride E. coli Evolution exposure to faster FIVE inhibitory inhibitory concentration K-12 mechanism minimum molecular mechanism Multidrug resistance Mutagenesis Mutation outbreak outer membrane phenotypic Protein rifampicin risk RNA polymerase sensitivity Sequencing significantly Usage whole-genome sequencing [DOI] 10.1016/j.scitotenv.2022.155090 PMC 바로가기 [Article Type] Article
Repeated transmission of SARS-CoV-2 in an overcrowded Irish emergency department elucidated by whole-genome sequencing전체 게놈 시퀀싱으로 밝혀진 과밀 아일랜드 응급실에서 SARS-CoV-2의 반복 전파Article Published on 2022-08-012022-09-11 Journal: The Journal of hospital infection [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis assigned B.1.1.7 B.1.1.7 lineage bioinformatics Chain Reaction Cluster Community complex consensus genome Contact tracing COVID COVID-19 COVID-19 pandemic defined demonstrated effort emergency department epidemiologically Genomic epidemiology hospital Hospital overcrowding hospital ward Infection infections Limerick Local maximum-likelihood nasopharyngeal swabs occurred outbreak Outbreak investigation Oxford pangolin Patient Phylogenetic tree polymerase chain polymerase chain reaction Prevent Prevention and control protocol resulting reverse transcriptase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sequence Sequencing Single nucleotide polymorphism SNPs surveillance testing threshold transcriptase Transmission transmission of SARS-CoV-2 university Viral RNA viral RNA extracted Viral transmission was performed WGS whole-genome sequencing [DOI] 10.1016/j.jhin.2022.04.015 PMC 바로가기 [Article Type] Article
Confirming Multiplex RT-qPCR Use in COVID-19 with Next-Generation Sequencing: Strategies for Epidemiological Advantage차세대 시퀀싱으로 COVID-19에서 다중 RT-qPCR 사용 확인: 역학적 이점을 위한 전략Article Published on 2022-07-302022-09-11 Journal: Global health, epidemiology and genomics [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis analyzed characteristic complex Concordance COVID-19 Critical epidemiological exceptional Lineage Mutation mutations Next-generation sequencing NGS offer pandemic positive qPCR assays Rapid RT-qPCR RT-qPCR assay RT-qPCR assays SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants screened Spike protein Strategy synergy technique Transmission Transmission dynamics variant variants variants of concern VoC WHO whole-genome whole-genome sequencing [DOI] 10.1155/2022/2270965 PMC 바로가기 [Article Type] Article
Evaluation of EPISEQ SARS-CoV-2 and a Fully Integrated Application to Identify SARS-CoV-2 Variants from Several Next-Generation Sequencing ApproachesEPISEQ SARS-CoV-2 평가 및 여러 차세대 시퀀싱 접근 방식에서 SARS-CoV-2 변이체 식별을 위한 완전 통합 애플리케이션Article Published on 2022-07-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis application approach bioinformatics clade Concordance consensus sequence coronavirus Coverage effort Genome genome assembly genomic Genomic surveillance handling Laboratory Lineage Mutation mutation screening Next-generation sequencing Nextstrain Nextstrain clade NGS pango lineage platform reagents reference genome SARS-CoV-2 SARS-CoV-2 mutation Sequencing sequencing protocol severe acute respiratory syndrome Coronavirus spike mutation Support Surveillance variant variant identification. variety whole-genome sequencing [DOI] 10.3390/v14081674 PMC 바로가기 [Article Type] Article
Post-vaccination antibody evaluation for nosocomial SARS-CoV-2 delta variant breakthrough infection병원 내 SARS-CoV-2 델타 변이형 돌발성 감염에 대한 백신 접종 후 항체 평가Observational Study Published on 2022-07-252022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-S IgG Anti-spike anti-spike antibody antibody Asymptomatic B.1.617.2 BNT162b2 booster vaccination Breakthrough infection Care Casirivimab characterized collected coronavirus Course Delta variants diagnosed Diagnosis eight estimation geometric mean geometric mean titer GMT hospital Humoral immunity IgG Imdevimab Infection Inpatient LAMP Loop-mediated isothermal amplification lowest measurement Mild mild to moderate mild to moderate severity moderate monoclonal antibody mRNA vaccination nosocomial observational study outbreak public health quantified RBD protein remained respiratory retrospective risk RT-PCR SARS-CoV-2 SARS-CoV-2 delta SARS-COV-2 infection SARS-CoV-2 vaccination Sequencing serological serum sample serum samples Seven severe acute respiratory syndrome Coronavirus severity therapy Treatment uninfected vaccination variant virus viruses was done whole-genome sequencing [DOI] 10.1371/journal.pone.0272056 PMC 바로가기 [Article Type] Observational Study
COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme고충실도 CRISPR-Cas12 효소를 사용한 COVID-19 변이체 탐지Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis Assay validation circulating variant clinical sample clinical samples Concordance COVID-19 COVID-19 patient COVID-19 patients CRISPR CRISPR-Cas12 detection DETECTR Diagnostic method enzyme Enzymes faster followed by Genome sequencing guide RNAs identify infection control isothermal amplification L452R Laboratory test Laboratory tests LAMP Loop-mediated isothermal amplification Mutation mutations N501Y nucleotide omicron Patient polymorphism public health real-time RT-PCR RNAs SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing single nucleotide Single nucleotide polymorphism SNP Surveillance target the SARS-CoV-2 Treatment treatment of COVID-19 patients utility variant variants Viral mutations viral mutations. whole-genome sequencing [DOI] 10.1128/jcm.00261-22 PMC 바로가기 [Article Type] Article
Multifaceted Assessment of Wastewater-Based Epidemiology for SARS-CoV-2 in Selected Urban Communities in Davao City, Philippines: A Pilot Study필리핀 다바오 시의 일부 도시 커뮤니티에서 SARS-CoV-2에 대한 폐수 기반 역학의 다면 평가: 파일럿 연구Article Published on 2022-07-192022-09-11 Journal: International Journal of Environmental Research an [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed anthropogenic assessment attack rate city clinically collected Community complementary Concentration condition correlated country COVID-19 COVID-19 transmission cycle Cycle threshold values detect dissolved oxygen e genes Epidemiology exploratory extraction Factors fecal flow rate highlight lack Mutation NaCl nine over oxygen parameter Philippines physico-chemical properties plant platform polymorphism precipitation method provide provided public health public health surveillance RdRP reported risk of COVID-19 RNA RT-PCR salinity Sample SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 RNA Sequencing single-nucleotide SNPs subset Surface water Surveillance susceptible temperature the SARS-CoV-2 threshold value Transmission Treatment urban wastewater Wastewater-based epidemiology water Water Temperature Weekly WGS whole genome Whole genome sequencing whole-genome sequencing [DOI] 10.3390/ijerph19148789 PMC 바로가기 [Article Type] Article
Real-time allelic assays of SARS-CoV-2 variants to enhance sewage surveillance하수 감시를 강화하기 위한 SARS-CoV-2 변이체의 실시간 대립유전자 분석Article Published on 2022-07-152022-09-11 Journal: Water research [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] allele Allele-specific RT-qPCR allelic Alpha Analysis Beta Beta variant clinically Community sewage Concordance COVID-19 patient cross-reactivity Delta delta variant diagnosed discharged eight ENhance Gamma genotypes Hong Kong integration Lambda offer omicron Omicron variant outbreak provided qPCR quarantine real-time RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity sequence sewage Sewage surveillance specificity Surveillance variant variants Viral RNA whole-genome sequencing [DOI] 10.1016/j.watres.2022.118686 PMC 바로가기 [Article Type] Article
Detecting lineage-defining mutations in SARS-CoV-2 using colorimetric RT-LAMP without probes or additional primers프로브 또는 추가 프라이머 없이 비색 RT-LAMP를 사용하여 SARS-CoV-2에서 계통 정의 돌연변이 검출Article Published on 2022-07-072022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] advance alternatives approach caused concern country demonstrated develop epidemic wave Gamma Genetic variant help identify immune increasingly isothermal amplification lineages Loop-mediated isothermal amplification molecular monitoring Mutation nucleic acid nucleic acid amplification pandemic of COVID-19 primer probe proof proof of concept reaction RNA samples RT-LAMP SARS-CoV-2 SARS-CoV-2 RNA sensitivity sequencing coverage specificity sustained swab sample swab samples tested Transcription vaccination variant variants VoC whole-genome sequencing [DOI] 10.1038/s41598-022-15368-3 PMC 바로가기 [Article Type] Article