Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection: A ReviewReview Published on 2020-10-262023-06-16 Journal: The protein journal [Category] MERS, SARS, [키워드] angiotensin-converting enzyme 2 COVID-19 oxidative stress SARS SARS-CoV2 Spike protein [DOI] 10.1007/s10930-020-09935-8 PMC 바로가기 [Article Type] Review
Positive Selection of ORF1ab, ORF3a, and ORF8 Genes Drives the Early Evolutionary Trends of SARS-CoV-2 During the 2020 COVID-19 PandemicMicrobiology Published on 2020-10-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accessory protein Affect Analysis analyzed Antiviral characterized collected conserved country COVID-19 COVID-19 pandemic determine drive epistasis epistatic interaction Evidence Evolution evolutionary dynamics full-length SARS-CoV-2 genome genetic mechanism Genome groups Helicase highlight humans indicated non-structural protein observation ORF1ab ORF3a ORF8 pandemic Phylogenetic Positive selection public health residue Result SARS-CoV-2 SARS-CoV2 Selection sequence therapeutic trend Vaccines variant [DOI] 10.3389/fmicb.2020.550674 PMC 바로가기 [Article Type] Microbiology
Coronavirus Infection of the Central Nervous System: Animal Models in the Time of COVID-19Veterinary Science Published on 2020-10-232022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] animal animal coronavirus antiviral drug Central nervous system clinical trials CNS Coronaviral coronavirus Coronavirus infection COVID-19 COVID-19 patients difference direct infection Factor Feline infectious peritonitis (FIP) GS-441524 Host incidence increasingly Infection mechanism MERS-CoV Model Naturally nervous neurological pathology recent reflected Remdesivir SARS-CoV SARS-CoV-2 SARS-CoV2 similarity time Treatment Variation [DOI] 10.3389/fvets.2020.584673 PMC 바로가기 [Article Type] Veterinary Science
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19SOCS, 내재 독성 인자 및 COVID-19의 치료Review Published on 2020-10-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome antagonist antiviral peptide block caused Cell coronavirus COVID-19 COVID-19 pandemic cytokine signaling death Defense effective embryonic Factor Factors herpes simplex herpes simplex virus Herpes Simplex Virus 1 Host HSV-1 IFN IFNγ induce infections inflammatory disease Influenza influenza A influenza A virus inhibit inhibitor inhibitors inhibitory inhibitory activity interferon interferon gamma intrinsic JAK2 kinase kinases KIR leads mechanism mice Neonatal neonatal death Other palmitate pathogenic pathogenic virus penetration peptide phosphorylated Prevent Prophylactic required respiratory SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome shown SOCS1 SOCS3 Spike protein STAT STATs suppressor therapeutic transcription factor TYK2 type I tyrosine tyrosine kinase vaccinia virus Viral Viral virulence virulence virulence factors virus virus pathogenesis viruses [DOI] 10.3389/fimmu.2020.582102 PMC 바로가기 [Article Type] Review
Structural Characterization of N‐Linked Glycans in the Receptor Binding Domain of the SARS‐CoV‐2 Spike Protein and their Interactions with Human LectinsResearch Article Published on 2020-10-222022-10-28 Journal: Angewandte Chemie (International ed. in English) [Category] COVID-19, SARS, [키워드] 3D model affected analysed analyses Analysis characterization characterized complexes epitope evaluated Evidence experiment expressed glycan glycoprotein HEK293F cell Human identify infection process Interaction lectin molecular recognition NMR NMR spectroscopy organ Perspective Receptor binding domain reported responsible SARS-CoV2 SARS‐CoV‐2 SARS‐CoV‐2 spike SARS‑CoV2 spike glycoprotein Structure the RBD tissue [DOI] 10.1002/anie.202011015 PMC 바로가기 [Article Type] Research Article
“Early transfusion of convalescent plasma in older patients with COVID-19 to prevent disease progression: A structured summary of a study protocol for a randomised controlled trial”Letter Published on 2020-10-222022-10-29 Journal: Trials [Category] COVID-19, MERS, SARS, [키워드] 1:1 ABO accompany addition Adult patient adverse event age anti-SARS-CoV-2 antibody Antibody titer anticipated blood product Cardiopulmonary CCP CDC Comorbidities Comorbidity conducted convalescent plasma COVID-19 COVID-19 pneumonia patient criteria decrease Decreased defined disease dissemination dose elderly element eligible for inclusion hospital Identifier IgA increase Increased information investigator IRCCS Italy Length life-threatening Nasopharyngeal swab number objective older patient Open-label outcome paO2/fiO2 parallel group participant Patient performed phase plasma Pneumonia positive Prevent proceed progression protocol pulmonary disease randomised randomised controlled randomised controlled trial Randomized receive recipients recruitment refusal Registered risk SAE Sample size SARS-CoV2 secondary Secondary objective sequence severe pneumonia severity Sex Standard Standard therapy status Stratification Study protocol the patient therapy titre Total Trial two-tailed Viral load Viremia website WHO with COVID-19 worsening [DOI] 10.1186/s13063-020-04821-1 PMC 바로가기 [Article Type] Letter
Perspective: Reducing SARS-CoV2 Infectivity and Its Associated Immunopathology관점: SARS-CoV2 감염성 감소 및 관련 면역병리학Immunology Published on 2020-10-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료제, [키워드] antibody approach approaches consequence COVID-19 Hyperinflammatory immune immunoregulation Infection Infectivity Inflammation Inflammatory response initiated mediators microbe microbes mitigate nanobodies neutralize organelle outcome Patient reaction reduce referred to SARS-CoV2 sdAb selected Smaller subcellular therapy utility virus viruses [DOI] 10.3389/fimmu.2020.581076 PMC 바로가기 [Article Type] Immunology
Neurological manifestations in coronavirus disease 2019 (COVID-19) patients: a systematic review of literatureReview Published on 2020-10-212022-10-31 Journal: CNS Spectrums [Category] COVID-19, MERS, [키워드] Affect Analysis ARDS article available data cause CNS controlled trials Corona virus coronavirus disease COVID-19 COVID-19 patients COVID-19 severity database diagnosed with COVID-19 Dizziness eligibility excluded glial cell headache highest incidence induce Infection limitations manifestation neurological Neurological complication neurological manifestation neurological manifestations Neurological symptom Neuron nonrandomized objective observational study occur Participants Pathologies Patient patients Pediatric patient reported representing Result SARS-CoV2 Severe patient Symptom systematic literature search systematic review the disease virus was performed [DOI] 10.1017/S1092852920001935 PMC 바로가기 [Article Type] Review
Management of Pregnant Inflammatory Bowel Disease Patients During the COVID-19 PandemicArticle Published on 2020-10-212023-07-06 Journal: Journal of Crohn's & colitis [Category] SARS, [키워드] COVID-19 Inflammatory bowel disease Pregnancy SARS-CoV2 [DOI] 10.1093/ecco-jcc/jjaa125 PMC 바로가기
Clinical Trials for Inflammatory Bowel Disease: Global Guidance During the COVID-19 PandemicPractice Guideline Published on 2020-10-212023-07-06 Journal: Journal of Crohn's & colitis [Category] SARS, [키워드] clinical trials COVID-19 Crohn’s disease Inflammatory bowel disease SARS-CoV2 ulcerative colitis [DOI] 10.1093/ecco-jcc/jjaa119 PMC 바로가기 [Article Type] Practice Guideline