DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4 + T-Cell Population StructureDNA 메틸화는 건강한 대조군과 알레르기 환자를 분리하고 변경된 CD4 + T-세포 집단 구조를 반영할 수 있습니다.Research Article Published on 2014-01-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] allergen allergic allergic rhinitis allergy alteration Altered approach assumed Author blood cell CD4 cells change changes in compared Control controls different disease DNA DNA methylation Epigenetic epigenomics etiology Evidence explain found Gene Expression gene expression profile Gene expression profiles healthy control healthy controls healthy individual healthy individuals heterogeneity highlight humans Illumina immune in vitro model individuals infectious agent infectious agents Inflammatory diseases life mechanism memory Methylation Microarrays molecular Patient PBMC PBMCs phenotype Population profile proportion proportions psoriasis purified SAR seasonal Seasonal allergic rhinitis Separate separation Stratification Structure subtype Support T cells T-cell T-cells White blood cell [DOI] 10.1371/journal.pgen.1004059 PMC 바로가기 [Article Type] Research Article
Measuring T cell receptor and T cell gene expression diversity in antigen-responsive human CD4+ T cells항원 반응성 인간 CD4+ T 세포에서 T 세포 수용체 및 T 세포 유전자 발현 다양성 측정journal-article Published on 2013-12-012024-07-30 Journal: Nursing Reports [Category] 파상풍, [키워드] Gene Expression Human T cell receptor T cells [DOI] 10.1016/j.jim.2013.11.003 [Article Type] journal-article
Dendritic Cell-Specific Delivery of Flt3L by Coronavirus Vectors Secures Induction of Therapeutic Antitumor ImmunityResearch Article Published on 2013-11-282022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antigen CD8 Combination compared coronavirus cytokine DC DCs delivery dendritic cell Efficacy epitope exhibited Express Host IL-15 IL-2 Immunity in vivo induce induction Ligand lymphocyte maturation microenvironment priming Prophylactic PROTECT provided T cell T cells therapeutic transduced Tumor tumor immunity tyrosine vaccination vector [DOI] 10.1371/journal.pone.0081442 PMC 바로가기 [Article Type] Research Article
TCR-Engineered T Cells Meet New Challenges to Treat Solid Tumors: Choice of Antigen, T Cell Fitness, and Sensitization of Tumor MilieuReview Article Published on 2013-11-082023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] antigens inhibitory micro-milieu solid tumors T cell avidity T cell co-stimulation T cells TCR affinity TCR transgenes [DOI] 10.3389/fimmu.2013.00363 PMC 바로가기 [Article Type] Review Article
MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitisResearch Article Published on 2013-10-242022-10-28 Journal: ASN NEURO [Category] Coronavirus, [키워드] accumulate BBB, blood brain barrier Blood brain barrier CD4 CD4 T cells CD8 Central nervous system chemokine CNS CNS, Central Nervous System coronavirus decrease disease severity EAE, experimental autoimmune encephalitis Encephalitis expression facilitate Glia glia limitans IFNγ, interferon γ IFNγ induce Infection Infectious virus Inflammatory response interferon γ limitans mAb, monoclonal antibody matrix metalloproteinase matrix metalloproteinases MHV, mouse hepatitis virus mice Migration MMP, matrix metalloproteinase neurotropic not affected Pathogenesis perivascular perivascular cuff PFA, paraformaldehyde recruitment reduced responsible suggested T cell T cell subset T cells TIMP-1 TIMP, tissue inhibitor of matrix metalloproteinases tissue damage Tissue Inhibitor virus WT, wild-type [DOI] 10.1042/AN20130033 PMC 바로가기 [Article Type] Research Article
Different Mechanisms of Inflammation Induced in Virus and Autoimmune-Mediated Models of Multiple Sclerosis in C57BL6 MiceResearch Article Published on 2013-08-282022-10-27 Journal: BioMed Research International [Category] Coronavirus, [키워드] accumulated Acute inflammation Autoimmune CD4 CD8 Central nervous system chronic disease CNS Course demonstrated Demyelination disease distribution glycoprotein Immunosuppression induce induced Inflammation Inflammatory Injury involved mechanism MHV MHV-A59 mice microglia Model MOG Multiple pathology patients promote responsible sclerosis significant difference T cell T cells the disease viral toxicity viral-induced [DOI] 10.1155/2013/589048 PMC 바로가기 [Article Type] Research Article
Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria뇌 미세혈관의 교차 제시는 실험적 뇌 말라리아의 특징입니다.Research Article Published on 2013-07-162024-08-13 Journal: EMBO Molecular Medicine [Category] 말라리아, [키워드] Brain cross-presentation malaria pathology T cells [DOI] 10.1002/emmm.201202273 PMC 바로가기 [Article Type] Research Article
Host and Microbial Factors in Regulation of T Cells in the IntestineReview Article Published on 2013-05-102023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] commensal bacteria dendritic cells FOXP3 intestine retinoic acid T cells Th17 [DOI] 10.3389/fimmu.2013.00141 PMC 바로가기 [Article Type] Review Article
Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases기능성 IL6R 358Ala 대립유전자는 전통적인 IL-6 수용체 신호 전달을 손상시키고 다양한 염증성 질환의 위험에 영향을 미칩니다Research Article Published on 2013-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 358Ala Abdominal aortic aneurysm affecting allele analyzed aortic aneurysm approach Arthritis Asp358Ala association Asthma Atrial fibrillation Author balance benefit Cambridge BioResource causal variant CD4+ T cell CD4+ T cells CHD Chronic diseases circulating cleavage clinical trial clinical trials common diseases complex complex diseases Concentration Control copy Coronary heart disease Critical cytokine diabete diabetes etiology Evidence expression functional Genetic genetic association Genetic variation heart disease human disease identify IL-6 IL-6 receptor IL-6 signaling IL-6R IL-6R signaling IL-6R signaling pathway IL6R Immune cell immune cells impairment implicated implication increase increase in independent Inflammatory Inflammatory responses influence interleukin interleukin-6 isoform mechanism membrane-bound molecular mechanism monocyte Monocytes mononuclear cell mononuclear cells Non-synonymous nucleotide Patient PBMCs Peripheral blood Peripheral blood mononuclear cells Phosphorylation polymorphism Population protein level protein levels RA reduce reduced reduction regulated Regulation rheumatoid arthritis risk rs2228145 Signaling sIL-6R single nucleotide Single nucleotide polymorphism soluble IL-6R Stat1 STAT3 Stimulation suggested surface expression surface receptor susceptibility T cells T1D therapeutic intervention therapy These data Transcription transcription factor transcription factors translate Treatment response Type 1 diabetes variant Variation Volunteer [DOI] 10.1371/journal.pgen.1003444 PMC 바로가기 [Article Type] Research Article
ImmunoChip Study Implicates Antigen Presentation to T Cells in NarcolepsyImmunoChip 연구는 기면증에서 T 세포에 대한 항원 제시를 의미합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Alpha Antigen presentation antigen processing Author Autoimmune autoimmune and inflammatory diseases autoimmune attack Autoimmune disease Cathepsin H chromosome chromosome 6 class compared Consensus Control controls CTSH deficiency disease pathogenesis disease risk encoded protein encoded proteins environmental exposure European Gene Genes genome-wide significance genotyped genotyping high-density genotyping platform HLA HLA class II HLA DQB1*06:02 Human human leukocyte antigen hypocretin cells ImmunoChip immunological synapse implicated in addition to individual inflammatory disease Inflammatory diseases Interaction leukocyte Ligand loci mechanism Narcolepsy narcolepsy-hypocretin deficiency OX40L pathophysiology pathway post-infectious autoimmune presentation progression recent selective significantly study variant Support susceptibility T cell T cell receptor T cell response T cells the disease TNFSF4 TNFSF4/OX40L tumor necrosis tumor necrosis factor unique variant variants while [DOI] 10.1371/journal.pgen.1003270 PMC 바로가기 [Article Type] Research Article