Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication CycleAntiviral Agents Published on 2020-06-082022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, SARS, [키워드] 50% effective concentration acute respiratory syndrome antiparasitic drug Antiviral agents antiviral drug benefit binding Calu-3 Cell Cell culture coronavirus COVID-19 COVID-19 patients cycle drug Drug repurposing epithelial epithelial cell line human lung human serum impacted Infection inhibit inhibited log pandemic performed Plaque reduction assay Prevent primary human airway progression provide public health randomized clinical trials Registered Replication SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication step Suramin treat treated Vero E6 cell Viral load virus Wuhan, China [DOI] 10.1128/AAC.00900-20 PMC 바로가기 [Article Type] Antiviral Agents
Atypical Neurological Manifestations of COVID-19Neurology Published on 2020-06-082022-10-31 Journal: Cureus [Category] COVID-19, [키워드] added aerosol route clinical manifestation cns manifestations Complication coronavirus cough COVID-19 described diarrhea early diagnosis fatigue Fever identify knowledge manifestation nasal congestion nervous system neurological manifestation neurological signs and symptoms Novel coronavirus SARS-CoV-2 SARS-CoV-2 positive patients transmitted virus worldwide pandemic [DOI] 10.7759/cureus.8518 PMC 바로가기 [Article Type] Neurology
Managing anticoagulation in the COVID-19 era between lockdown and reopening phasesIM-Point of view Published on 2020-06-082022-10-30 Journal: Internal and Emergency Medicine [Category] Coronavirus, MERS, SARS, [키워드] activity Anticoagulant Anticoagulant treatment anticoagulation COVID-19 COVID-19 pandemic diffusion DOAC Federation Guidance highest Italian Italy lockdown managing non-infected offer Oral anticoagulants pandemic Patient Patient care patients Prevalence Prevent Surveillance total population virus Warfarin [DOI] 10.1007/s11739-020-02391-3 PMC 바로가기 [Article Type] IM-Point of view
Subcutaneous administration of interferon beta-1a for COVID-19: A non-controlled prospective trialArticle Published on 2020-06-072022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 임상, [키워드] administration Adverse drug reaction age Antiviral clearance clinical Clinical symptoms Combination coronavirus country COVID-19 death demographic dose Effect Epidemic evaluate Hospitalization Hydroxychloroquine imaging immunomodulatory effects include infected cells interferon Interferon beta-1a interferons management maturation New coronavirus Patient patients previous study Prospective trial protein synthesis Pulmonary infection recorded resolved Result Seven shown significant decrease Spread subcutaneous administration subcutaneously Support susceptible Symptom the patient therapeutic effect therapy Trial Trial registration viral replication virological clearance virus [DOI] 10.1016/j.intimp.2020.106688 PMC 바로가기 [Article Type] Article
The origin and underlying driving forces of the SARS-CoV-2 outbreakSARS-CoV-2 발병의 기원과 근본적인 원동력Research Published on 2020-06-072022-08-13 Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, SARS, [키워드] adaptive Analysis analyzed China collected concerning coronavirus Critical determine driving effective Effectiveness Epidemic Evolution excess Frequency genetic diversity had more Haplotype haplotypes hospital HPD Human humans impacted interior Intervention lockdown low frequency Mutation Mutational bias mutations network analysis nonsynonymous observation occurred ORF8 protein outbreak pandemic pangolin Population genetics Population size Positive selection Protein Receptor binding domain Relaxation reported required Result SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence sequence similarity social distancing Spike receptor binding domain Spread synonymous the SARS-CoV-2 Variation virus Wuhan [DOI] 10.1186/s12929-020-00665-8 PMC 바로가기 [Article Type] Research
Neutrophil to CD4+ lymphocyte ratio as a potential biomarker in predicting virus negative conversion time in COVID-19Article Published on 2020-06-062022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 바이오마커, [키워드] Accuracy Analysis AUC Biomarker calculated CD4+ Chest China Clinical outcome conducted contribute COVID-19 COVID-19 patients diagnostic disease Disease progression evaluate fatigue Fever incidence independent risk factor Inflammatory lymphocyte Lymphocyte subsets Multivariate analysis Negative conversion Negative conversion time neutrophil Neutrophil to CD4+ lymphocyte ratio NLR Novel coronavirus occurred Older Patient patients Pneumonia Predictive receiver operating characteristic Result ROC ROC analysis SARS-CoV-2 Spread virus were used Wuhan [DOI] 10.1016/j.intimp.2020.106683 PMC 바로가기 [Article Type] Article
Propagation, Inactivation, and Safety Testing of SARS-CoV-2Article Published on 2020-06-062022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Biosafety Level 3 causes Cellulose Chinese coronavirus COVID-19 deaths described DNA effective facilitated focus forming assay inactivation infected cell Infection Infectious virus multiple cell line neutral buffered formalin new virus Novel coronavirus pandemic performed Plaque assay Propagation Protein quantification Research responsible resulting RNA Safe Safety SARS-CoV-2 Testing the disease Trizol Virology virus virus infectivity widespread worldwide pandemic Wuhan [DOI] 10.3390/v12060622 PMC 바로가기 [Article Type] Article
Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in nonhospitalized COVID‐19 patientsCase Reports Published on 2020-06-052022-10-04 Journal: Journal of medical virology [Category] SARS, 치료기술, [키워드] alternative medicine Antibody test antibody test positive attenuate Combination COVID‐19 COVID‐19 patient COVID‐19 symptoms COVID‐19 derivative detection Diagnosis Disease progression effective exhibited genomic gold standard help implementation Infection lower respiratory system medical system pandemic Patient PCR test negative positive PCR test prolonged symptoms RT‐PCR SARS‐CoV‐2 survival Suspected Symptom Symptoms therapeutic effect Treatment treatment regimen virus Vitamin C were used [DOI] 10.1002/jmv.26064 PMC 바로가기 [Article Type] Case Reports
A Case of Critically Ill Infant of Coronavirus Disease 2019 With Persistent Reduction of T LymphocytesOriginal Studies Published on 2020-06-052022-10-28 Journal: The Pediatric Infectious Disease Journal [Category] COVID-19, SARS, [키워드] Acute kidney injury acute respiratory syndrome administration cause CD3+ CD4+ CD4+ T cell CD8+ T cell CD8+ T cells children Clinical characteristics clinical feature Contact content coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical Critical case critical cases Critically ill declined Digital effector memory Fever Follow-up Ill Infant information Injury laboratory data life-threatening lymphopenia mother nasopharyngeal nucleic acid test outbreak Pediatric case Pediatric patient persistent predict reduction reported Septic shock serum antibody severity T cells T-cell the disease transmission of SARS-CoV-2 Treatment unlikely virus was related were recorded with COVID-19 [DOI] 10.1097/INF.0000000000002720 PMC 바로가기 [Article Type] Original Studies
Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARSImmunology Published on 2020-06-052022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] absence ADE antibody antibody dependent enhancement (ADE) Antigen antigenic antigenic sin arise cause children Clinical course Clinical sign contrary convalescent sera coronavirus Coronavirus infection coronavirus strain Course COVID-19 cross-reactive cross-reactive antibody cross-reactivity Dependent described development ENhance enhancement expected Human IgG immune response immune system Infection infection with SARS-CoV-2 infections memory new virus original pandemic Patient patients progression protecting IgG Protective question Receptor binding protein related virus respiratory tract infection respond SARS-CoV-2 Sin Spike protein the SARS-CoV-2 treating COVID-19 patient viral clearance viral infections virus [DOI] 10.3389/fimmu.2020.01120 PMC 바로가기 [Article Type] Immunology