Controlled Heat and Humidity-Based Treatment for the Reuse of Personal Protective Equipment: A Pragmatic Proof-of-Concept to Address the Mass Shortage of Surgical Masks and N95/FFP2 Respirators and to Prevent the SARS-CoV2 TransmissionMedicine Published on 2020-10-202022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] address Bacteria circumvent Controlled coronavirus COVID-19 Effect Evidence facemask feasibility FFP2/N95 filtration healthcare heat Heating Mask Masks mass N95/FFP2 respirator Oropharyngeal overcome pandemic Personal protective equipment recyclibility required resources Respirator respiratory viruses SARS-CoV2 SARS–CoV-2 surgical surgical face masks tested Treatment [DOI] 10.3389/fmed.2020.584036 PMC 바로가기 [Article Type] Medicine
Can Neuron Specific Enolase Be a Diagnostic Biomarker for Neuronal Injury in COVID-19?Neurology Published on 2020-10-192022-10-31 Journal: Cureus [Category] COVID-19, [키워드] accompanied acute respiratory syndrome Biomarker Brain Can cerebrospinal fluid China Clinical outcome coronavirus coronavirus disease COVID-19 COVID-19 patient CSF disease disorder elevated Encephalitis Encephalopathy hemorrhages include Infection Injury Intracerebral hemorrhage loss of taste mechanical ventilation Metastasis Mild Neuroinflammation Neurological symptom Neuron neuron specific enolase neuronal nse observation Patient patients Protein Respiratory system SARS-CoV-2 SARS-CoV2 serum stroke Symptom syndrome upper respiratory symptom while White blood cell with COVID-19 [DOI] 10.7759/cureus.11033 PMC 바로가기 [Article Type] Neurology
COVID-19 and Sick Leave: An Analysis of the Ibermutua Cohort of Over 1,651,305 Spanish Workers in the First Trimester of 2020Public Health Published on 2020-10-192022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] adjusted affected Analysis analyzed causes contagious Costs COVID-19 disease greater Health heterogeneous highest impacted incidence increase in over pandemic Patient regions respiratory diseases SARS-CoV2 Sex shown sick sick leave Spain Spanish stratified trimester women worker [DOI] 10.3389/fpubh.2020.580546 PMC 바로가기 [Article Type] Public Health
Molecular docking study of potential phytochemicals and their effects on the complex of SARS-CoV2 spike protein and human ACE2Article Published on 2020-10-192022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 protein affected Analysis analyzed angiotensin converting enzyme antiviral activity binding binding energy binding site cause Chinese competent complex Compound Computational chemistry conformational change coronavirus COVID-19 Effect effective emodin FIVE human ACE2 in silico indicate Infection medication modulate molecular molecular docking Molecular docking study natural Novel coronavirus patients plants Protein receptor receptor ACE2 Safe SARS-CoV2 selected small molecule Spike protein three-dimensional structure transmembrane protein treat Trial Virtual drug screening [DOI] 10.1038/s41598-020-74715-4 PMC 바로가기 [Article Type] Article
COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future ManagementPharmacology Published on 2020-10-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome alleviate alternative method antiviral treatments Candidates characterized coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 CoV COVID-19 current effective Epidemiology etiology Future inhibit life-threatening MERS-CoV Middle East Middle East respiratory syndrome Coronavirus Novel coronavirus pathogenesis of COVID-19 Potential public health Replication respiratory syndrome coronavirus SARS-CoV SARS-CoV2 severe acute respiratory syndrome coronavirus-2 specific treatment spread of COVID-19 Symptom therapeutic intervention therapeutic interventions threat Transmission Treatment virus WHO World Health Organization Wuhan, China [DOI] 10.3389/fphar.2020.563478 PMC 바로가기 [Article Type] Pharmacology
De novo design, retrosynthetic analysis and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2Research Article Published on 2020-10-152022-10-27 Journal: Biology open [Category] COVID-19, [키워드] De novo designing ACE2 Analysis angiotensin converting enzyme 2 Antiviral antiviral molecule Ascorbate bind binding caused complex COVID-19 disease de novo dependent on docking domain enzyme hACE2 high mortality human Angiotensin-converting enzyme Hybrid antiviral molecule Hydroxychloroquine Infection inhibit interact Interaction MDs molecular Molecular dynamics simulation morbidity outbreak Pathogenesis Protein RBD RBD-ACE2 recognize responsible Retrosynthetic analysis ribavirin SARS-CoV2 SARS-CoV2 spike glycoprotein SARS-like coronavirus spike spike glycoprotein Spike protein tested the receptor-binding domain variant virus were used [DOI] 10.1242/bio.054056 PMC 바로가기 [Article Type] Research Article
De novo design, retrosynthetic analysis and combinatorial synthesis of a hybrid antiviral (VTAR-01) to inhibit the interaction of SARS-CoV2 spike glycoprotein with human angiotensin-converting enzyme 2Research Article Published on 2020-10-152022-10-27 Journal: Biology open [Category] Coronavirus, COVID-19, Fulltext, [키워드] De novo designing ACE2 Analysis angiotensin converting enzyme 2 Antiviral antiviral molecule Ascorbate bind binding caused complex COVID-19 disease de novo dependent on docking domain enzyme hACE2 high mortality human Angiotensin-converting enzyme Hybrid antiviral molecule Hydroxychloroquine Infection inhibit interact Interaction MDs molecular Molecular dynamics simulation morbidity outbreak Pathogenesis Protein RBD RBD-ACE2 recognize responsible Retrosynthetic analysis ribavirin SARS-CoV2 SARS-CoV2 spike glycoprotein SARS-like coronavirus spike spike glycoprotein Spike protein tested the receptor-binding domain variant virus were used [DOI] 10.1242/bio.054056 PMC 바로가기 [Article Type] Research Article
Endothelial dysfunction in COVID-19: Current findings and therapeutic implicationsReview Article Published on 2020-10-142023-06-16 Journal: Atherosclerosis [Category] MERS, SARS, [키워드] coronavirus COVID-19 Endothelial dysfunction renin angiotensin system SARS-CoV2 statin [DOI] 10.1016/j.atherosclerosis.2020.10.014 PMC 바로가기 [Article Type] Review Article
Pharmacological insight into potential therapeutic agents for the deadly Covid-19 pandemicReview Published on 2020-10-132023-06-14 Journal: European journal of pharmacology [Category] MERS, SARS, [키워드] Convalescent plasma therapy and mesenchymal stem cell therapy coronavirus COVID-19 Drug repurposing SARS-CoV2 Vaccines [DOI] 10.1016/j.ejphar.2020.173643 PMC 바로가기 [Article Type] Review
COVID-19, Sistema Renina-Angiotensina, Enzima Conversora da Angiotensina 2 e Nicotina: Qual a Inter-Relação?Carta Científica Published on 2020-10-132022-10-28 Journal: Arquivos Brasileiros de Cardiologia [Category] Coronavirus, MERS, SARS, [키워드] Betacoronavirus, SARS-CoV2 Coronavirus/complicações COVID-19 SARS-CoV2 Syndrome Respiratory Acute [DOI] 10.36660/abc.20200653 PMC 바로가기 [Article Type] Carta Científica