Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation글루코사민은 Crz1 핵 전위를 촉진하여 Cryptococcus neoformans에서 페로몬 독립적인 이형 전이를 자극합니다Research Article Published on 2017-09-122022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Antifungal antifungal therapy attenuate calcineurin caused Cell cellular response clinically complex component Cryptococcal cells cryptococcal meningitis cryptococcosis Cryptococcus Cryptococcus neoforman Cryptococcus neoformans cytoplasm demonstrated disease downstream effector effectors elicited fertile fungal Genetic genetic screen glucosamine glycerol Host Host immune response host immune responses hosts identity immune responses immune-stimulatory independent independent of Interaction isolate limitations majority mammalian MAPK Meningitis morphogenesis Morphological morphological change Morphotype nuclear translocation nucleus Pathogenesis pathway pheromone phosphatase promote promoted PROTECT raise recent reference strain responsible serotype shown signaling pathway stimulate stimulated strain Stress stress response subsequent suppressed switching transcription factor translocation Trigger undergo Vaccine Vaccine development virulence virulent yeast [DOI] 10.1371/journal.pgen.1006982 PMC 바로가기 [Article Type] Research Article
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa녹농균에 대한 방어를 위해서는 보존된 미토콘드리아 감시 경로가 필요합니다Research Article Published on 2017-06-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition Bacterial battery Caenorhabditis Caenorhabditis elegans Cell cellular structure conserved Critical cytological damage Defense defense mechanisms described Diseases dysfunction Effect elegan elegans element Ethanol expand exposure to family functions genetics Health heat homeostasis Host host defense human pathogen hypothermia hypoxia Imbalance immune responses include increasingly indicate Infection innate immune response Innate immunity Interaction intestinal kill leads liquid mammals mechanism mechanisms mitigate mitochondrial organelle organism Organisms overlap overlapping oxidative damage P . aeruginosa pathogen Pathogens pathway Physiology Prevent Protein Pseudomonas aeruginosa pyoverdine recognizing Regulation required respond response secreted selective shown Stress stress response Surveillance threat Toxicity transcriptomics unique upregulation variety virulence [DOI] 10.1371/journal.pgen.1006876 PMC 바로가기 [Article Type] Research Article
Evaluation of the Clinical and Microbiological Response to Salmonella Paratyphi A Infection in the First Paratyphoid Human Challenge Model살모넬라 파라티피 A 감염에 대한 임상 및 미생물학적 반응 평가: 첫 번째 파라티푸스 인간 도전 모델Article Published on 2017-04-152024-07-29 Journal: Clinical infectious diseases : an official publication of the Infectious [Category] 살모넬라증, [키워드] Enteric fever human challenge study immune responses paratyphoid infection Salmonella enterica Paratyphi A [DOI] 10.1093/cid/cix042 PMC 바로가기
Relationship between cell-mediated immunity to Varicella-Zoster virus and aging in subjects from the community-based Shozu Herpes Zoster studyArticle Published on 2017-02-012023-06-01 Journal: Journal of medical virology [Category] 두창, 수두, 홍역, [키워드] Cell-mediated immunity Epidemiology herpes zoster immune responses immunity/immunization Varicella-Zoster Virus virus classification [DOI] 10.1002/jmv.24629
Recombinant Adenoviruses Displaying Matrix 2 Ectodomain Epitopes on Their Fiber Proteins as Universal Influenza VaccinesArticle Published on 2017-01-182023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] Adenovirus HI loop immune responses M2e universal influenza vaccine [DOI] 10.1128/JVI.02462-16 PMC 바로가기
Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccinesArticle Published on 2016-11-222022-10-29 Journal: Nature Communications [Category] Coronavirus, [키워드] determine Du et al effective Efficacy elicit eliminated epitope evaluate host immune responses immune responses immunodominant life-threatening MERS coronavirus MERS-CoV Neutralizing non-neutralizing epitope probe significantly subunit Subunit vaccine the receptor-binding domain the vaccine transgenic mice Vaccine Vaccine design variant viruses [DOI] 10.1038/ncomms13473 PMC 바로가기 [Article Type] Article
Widespread Shortening of 3’ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection3' 번역되지 않은 영역의 광범위한 단축 및 증가된 엑손 포함은 감염에 대한 타고난 면역 반응의 진화적으로 보존된 특징입니다Research Article Published on 2016-09-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ UTR accompanied activated adaptive immune responses Bacteria Bacterial infection Bacterial infections cellular response Cellular responses change changes in characterized collected complementary conserved evade example ExoN expression Factor feature functional Gene Expression Gene regulation human macrophage human macrophages idea identify immune immune response immune responses Inclusion increase in Increased individuals Infection Innate innate immune response innate immune responses involved isoform less Listeria monocytogene Listeria monocytogenes Macrophage macrophages mechanism microRNA miRNAs mRNA non-human primates polyadenylation sites Post-infection pre-mRNA primates reduced Region regulate regulated Regulation repression response RNA Salmonella Typhimurium sequenced Sequencing shortening significantly Support tandem transcriptional response transcriptional responses upstream Usage UTRs Variation while whole blood sample [DOI] 10.1371/journal.pgen.1006338 PMC 바로가기 [Article Type] Research Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article
Vaccines for the prevention against the threat of MERS-CoVReview Published on 2016-04-062023-06-15 Journal: Expert review of vaccines [Category] MERS, [키워드] animal models immune responses MERS MERS-CoV neutralizing antibody protection Spike protein Vaccines [DOI] 10.1586/14760584.2016.1167603 PMC 바로가기 [Article Type] Review
Clinical development of RTS,S/AS malaria vaccine: a systematic review of clinical Phase I-III trialsArticle Published on 2015-12-312024-09-10 Journal: Future Microbiol [Category] 말라리아, [키워드] anti-CSP Anti-HBs AS01 AS02 geometric mean concentration immune responses RTS,S/AS vaccine efficacy. PMC 바로가기