Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다Research Article Published on 2016-09-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast [DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article
The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase VariationPilin N-말단 도메인은 Pilus 단계 변이 동안 Neisseria gonorrhoeae 변환 능력을 유지합니다Research Article Published on 2016-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation Amino acid amino acids Antibiotic resistance antigenic variant antigenic variation Bacteria bacterium can not Cell cleavage cleavage site competence Critical Defense demonstrated DNA domain ELISA ELISAs exhibited fiber foreign DNA form function gene transfer genetic determinant genetic determinants gonococcal gonococcal infection gonorrhea horizontal gene Horizontal gene transfer human pathogen Immune escape Infection isolates killing lead locus maintain mechanism Microscopy morphology Mutagenesis Mutation N-terminal N-terminal domain N-terminus natural transformation Neisseria gonorrhoeae neutrophil nonsense mutation Nonsense mutations nucleotide occur pathogenic phase PilE pili pilin pilus producing Protein purification Recombination recombination event Release released required residue residues responsible retained sexually transmitted infection single nucleotide Spread strain Strains subunit the disease these cell These cells thought transfer transformation transmitted twitching Type Type IV pilus undetectable unique uptake variant while wild-type [DOI] 10.1371/journal.pgen.1006069 PMC 바로가기 [Article Type] Research Article
Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signalingReview Published on 2016-05-192022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] Antiviral antiviral cytokine Antiviral innate signaling appear coronavirus diarrhea enteric Enteric coronavirus epidemic diarrhea epithelial epithelial cell epithelial cells Evidence feature gastroenteritis Gut high mortality Host host innate immunity IFN IFN antagonist IFN-α/β IFN-λ immune evasion infect Infection innate immune Innate immunity interferon Interferon regulation intestinal intestinal epithelia intestinal epithelial cell maintain modulate modulation mucosal surface Neonatal nsp1 PEDV Porcine deltacoronavirus Porcine epidemic diarrhea virus Signaling small intestine TGEV These viruses turn Type Type III IFN type III interferon virus viruses watery [DOI] 10.1016/j.virusres.2016.05.015 PMC 바로가기 [Article Type] Review
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure심부전의 사망률과 관련된 염색체 5q22의 유전적 변이 발견Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting activate addition African allergic allergy applied approach assays association Asthma Blood Cell chemokine chemokines chromosome clinical trial clinical trials cytokine death dendritic cell dendritic cells determinant development DNA methylation ENhance enhancer region epigenomic Evidence evidence of expressing expression Factor failure Follow-up gene encode Genetic Genetic variant Genome-wide association studies Genome-wide association study genotyping heart heart failure HEK293 high mortality human cell human tissues identify increase increased risk independent induce inhibiting knockdown leads maintain Mast cells maturation Meta-analysis molecular Monocytes Mortality multiple tissues NHLH1 Patient performed polymorphism Population populations Positive selection predicted promote replicated reporter reporter gene responses risk allele subject T helper T-cell therapeutic Therapeutics Therapies transcription factor TSLP turn variant Whole blood [DOI] 10.1371/journal.pgen.1006034 PMC 바로가기 [Article Type] Research Article
Transposon Dysregulation Modulates dWnt4 Signaling to Control Germline Stem Cell Differentiation in Drosophila트랜스포존 조절 장애는 초파리에서 생식선 줄기 세포 분화를 제어하기 위해 dWnt4 신호를 조절합니다Research Article Published on 2016-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acts aging Cancer cancers Cell cell fate cell population cell types chromatin Control degenerative degenerative diseases differentiation differentiation defects disease downregulated Drosophila element elements encapsulation expression facilitate female Genetic Genome germline GSC independent insight lead Ligand Loss maintain mammary marker mechanism methyltransferase modulate multicellular multicellular organism mutants oogenesis organism Perspective progression promote Proteins regulate regulated repress required Signaling somatic cells STEM stem cell stem cells sustained therapeutic tissue tissues transposable elements transposon transposons upregulation virus while Wnt Wnt4 [DOI] 10.1371/journal.pgen.1005918 PMC 바로가기 [Article Type] Research Article
Replication and shedding of MERS-CoV in Jamaican fruit bats ( Artibeus jamaicensis )Article Published on 2016-02-222022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] bat cells cellular change Clinical sign Dipeptidyl peptidase 4 disease DPP4 Evidence expression Gene Expression highlight histopathological Hypothesis Infection inoculated intestinal tract intrinsic investigated investigation Jamaican fruit bat lung Lungs maintain MERS-CoV Middle East moderate receptor replicate replicated reservoir respiratory syndrome coronavirus spike glycoprotein Virus shedding zoonotic [DOI] 10.1038/srep21878 PMC 바로가기 [Article Type] Article
Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, open-label, non-inferiority trialHIV 감염의 장기 관리를 위한 프로테아제 억제제 단독 요법: 무작위, 대조, 공개, 비열등성 시험Articles Published on 2015-09-142022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 adverse event age Antiretroviral therapy ART baseline benefit block CD4 Cell Clinical management Clinical outcome clinical risk Combination combination treatment computer-generated Controlled darunavir defined drug drug resistance enrolled finding Frequency funding Genetic GRADE grade 3 HIV HIV infection inferiority inhibitor Intention intention to treat international standard Kaplan-Meier Kaplan-Meier analysis Lopinavir maintain management monotherapy non-inferiority non-inferiority margin non-inferiority trial number once daily Open-label parallel-group participant positive Pragmatic preserved Primary outcome Probability Protease inhibitor protease inhibitors public sector randomisation randomisation list randomised Randomly rebound Registered Ritonavir Serious Adverse Events shown Standard stratified suppressed the patient therapy toxic effects Treatment treatment failure Trial Viral Viral load virus [DOI] 10.1016/S2352-3018(15)00176-9 PMC 바로가기 [Article Type] Articles
Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant대식세포에서 칸디다 알비칸스의 소진화는 필라멘트가 아닌 돌연변이에서 필라멘트를 복원합니다Research Article Published on 2014-12-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Antifungal treatment approach avirulent C. albican C. albicans Candida Candida albican Candida albicans Cdk8 Cell cell wall clinical setting complex component Compound connection drug resistance ENCODE environmental cue environmental cues Evolution example exhibited fungi gene encoding growth hosts hyphae hyphal identify in vivo Incubation induce Infection leads Macrophage macrophages maintain mechanism mediator Mediator complex microbe microevolution microevolutionary microorganism microorganisms Missense mutation murine mutant Mutation nucleotide pathogenic pathogenicity phagocytosis regulatory network responsible selection pressure Signaling signaling pathway single nucleotide strain subject the macrophage phagosome These data took place Transcription transcription factor transcription factors transcription regulation transcriptional transcriptional regulation undergo virulence whole genome yeast [DOI] 10.1371/journal.pgen.1004824 PMC 바로가기 [Article Type] Research Article
Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone MachinesHsp40s는 Hsp104 및 Hsp90 단백질 샤페론 기계의 기능을 지정합니다Research Article Published on 2014-10-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activities activity alteration amplification Bacterial C-terminal C-terminal domain Cell cellular chaperone chaperones competing complement complex complexes component conformation cooperation domain explain function functional functions growth help Hsp70 increasingly Interaction less machine maintain microorganism microorganisms overexpressed overexpressing plant plants polymers promote Propagation PROTECT Protein Proteins PSI regulate Regulation Replication respond specific activities Stress Support thermotolerance underlie yeast [DOI] 10.1371/journal.pgen.1004720 PMC 바로가기 [Article Type] Research Article
Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 ComplexBeclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다Research Article Published on 2014-10-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability [DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article