Highly feasible immunoprotective multicistronic SARS-CoV-2 vaccine candidate blending novel eukaryotic expression and Salmonella bactofection
새로운 진핵생물 발현과 살모넬라 박토펙션을 혼합한 매우 실현 가능한 면역보호 멀티시스트론 SARS-CoV-2 백신 후보
Article
Published on
Journal: Journal of advanced research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,
Journal: Journal of advanced research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단,
[키워드] Analysis
anti-SARS-CoV-2 immune responses
Antibody titers
antigen-specific antibody
Antiviral
CD4
CD8
Cell-mediated immunity
Cellular immune response
co-expression
COVID-19
Cytometry
demonstrated
determine
develop
DNA
domain
effective
Efficacy
Efficiency
elicited
epitope
Epitopes
eukaryotic
expressing
expression
feasible
Flow
flow cytometry
Frame
fused
gene delivery
heptad repeat
highest
humoral
immune responses
immunized mice
immunofluorescence assay
immunogenicity
IMPROVE
in vivo
increase in
investigated
mechanism
membrane protein
mice
mRNA
Multicistronic expression
multivalent vaccine
neutralizing antibody titers
nsp13
offer
Open reading frame
pandemic
peptide
polarization
Protein
protein expression
raised
RBD
recall
Receptor-binding domain
recorded
RNA
robust
Safe
Salmonella
SARS-CoV-2
SARS-CoV-2 gene
SARS-CoV-2 genes
SARS-CoV-2 neutralizing antibody
SARS-CoV-2 protein
SARS-CoV-2 proteins
SARS-CoV-2 vaccine
SARS-CoV-2 variant
SARS-CoV-2 variants
sera
Spike protein
splenocyte
splenocytes
suggested
T cell
T cells
targets
Th1
Th1 response
Th2 immunity
the spike protein
the vaccine
Vaccine
vaccine candidate
vaccine construct
variant
variants
were used
western blot
Western blot analysis
[DOI] 10.1016/j.jare.2021.07.007 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.jare.2021.07.007 PMC 바로가기 [Article Type] Article