Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016Report Published on 2021-04-052022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, [키워드] Abstract addition Affect amino acid change antibody Antibody binding antibody cocktail antibody escape antigenic evolution B.1.351 B.1.429 bamlanivimab binding circulating Combination Complete coronavirus disease COVID-19 deep mutational scanning E484K Effect Efficacy effort epitope Evolution highlight identify individual Interpretation L452R Lineage LY-CoV555 Map monoclonal antibody Mutation P.1 Prophylaxis RBD SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 mutation SARS-CoV-2 RBD spike receptor-binding domain the SARS-CoV-2 therapeutic Therapeutic antibody variants of concern Variation [DOI] 10.1016/j.xcrm.2021.100255 PMC 바로가기 [Article Type] Report
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice Research Published on 2021-03-252022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 angiotensin-converting enzyme 2 antibodies antibody antibody cocktail approach approaches bind binding cellular receptor detectable disease Donor effective epitope escape mutant feasible IgG independent Lung inflammation mice monoclonal antibodies neutralize parental Prevent PROTECT RBD SARS-COV-2 infection SARS-CoV-2 variant Spike protein suppresse the RBD the receptor-binding domain the SARS-CoV-2 variants of concern viral escape virus wild-type SARS-CoV-2 [DOI] 10.1038/s41586-021-03461-y [Article Type] Research
SARS-CoV-2 N501Y Introductions and Transmissions in Switzerland from Beginning of October 2020 to February 2021—Implementation of Swiss-Wide Diagnostic Screening and Whole Genome SequencingArticle Published on 2021-03-252022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Amplicon sequencing analysed B.1.1.7 B.1.351 Brazil Community COVID-19 described diagnostic epidemiological event Genome implementation Lineage Molecular epidemiology multiple laboratories Mutation N501Y P.1 PCR Phylogenetic analysis positive protocol public health rapid increase recommendation reported researchers SARS-CoV-2 Screening Sequencing South Africa Spread subsequent Surveillance Switzerland the SARS-CoV-2 variant variants of concern VOCs WGS whole genome [DOI] 10.3390/microorganisms9040677 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants reveal features critical for replication in primary human cellsSARS-CoV-2 변이체는 1차 인간 세포에서 복제에 중요한 기능을 나타냅니다Research Article Published on 2021-03-242022-08-13 Journal: PLoS Biology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus BEpCs bronchial epithelial cell causative agent change characterization characterized circulation clade contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 pandemic Critical D614G variant deaths Deletion determine effort epithelial cells European exhibited experiments expressing feature furin furin cleavage site Genetic variant highlight human population human respiratory cell human SARS-CoV-2 Infection isolate kinetic MONITOR NSP2 ORF3a pandemic Patient Phenotypes primary differentiated human bronchial epithelial cells primary human cell primary human cells primary human respiratory cells Q57H Replication representing respiratory SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants selected sequence Sequencing sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike D614G variant Spread Substitution substitutions T85I the Spike Transmission variant variants of concern Vero-CCL81 Vero-CCL81 cell Vero-CCL81 cells Viral virus virus replication virus stocks while [DOI] 10.1371/journal.pbio.3001006 PMC 바로가기 [Article Type] Research Article
Updated rapid risk assessment from ECDC on the risk related to the spread of new SARS-CoV-2 variants of concern in the EU/EEA – first updateEU/EEA에서 우려되는 새로운 SARS-CoV-2 변종 확산과 관련된 위험에 대한 ECDC의 신속한 위험 평가 업데이트 – 첫 번째 업데이트Miscellaneous Published on 2021-01-212022-09-10 Journal: Eurosurveillance [Category] Fulltext, MERS, 변종, [키워드] ECDC new SARS-CoV-2 risk Spread variants of concern [DOI] 10.2807/1560-7917.ES.2021.26.3.2101211 PMC 바로가기 [Article Type] Miscellaneous
Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoVSARS-CoV-2 및 SARS-CoV 모두에 대해 교차 중화 활성을 갖는 인간 단일클론 항체인 MW06의 특성화Article Published on 2021-01-012022-09-11 Journal: mAbs [Category] 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition ADE alignment angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 antibody antibody-based therapy Antibody-dependent enhancement antibody-dependent enhancement (ADE) assays authorization B.1.1.7 B.1.351 B.1.617.1 bind caused characterization clinical trial cocktail complex conserved coronavirus coronavirus strains COVID-19 cross-neutralization activity cross-reactive demonstrated disrupt Effect effective effective interventions Emergency use epitope global pandemic Human monoclonal antibody in vitro assays Interaction Intervention mAb mAbs monoclonal antibody mutations neutralization neutralization activity neutralization. neutralizing monoclonal antibodies P.1 Phase 2 Potential Prevent Prophylactic provide RBD receptors recognize respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-related coronavirus severe acute respiratory syndrome Coronavirus spike receptor-binding domain Strains therapeutic efficacy Treatment treatment of COVID-19 variant variants variants of concern widespread [DOI] 10.1080/19420862.2021.1953683 PMC 바로가기 [Article Type] Article