A Dual Role for SOX10 in the Maintenance of the Postnatal Melanocyte Lineage and the Differentiation of Melanocyte Stem Cell Progenitors출생 후 멜라닌 세포 계통의 유지와 멜라닌 세포 줄기 세포 전구체의 분화에서 SOX10의 이중 역할Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adult stem cells appear Author cause Cell cell fate cell type Critical differentiation downregulated downstream driving embryogenesis exacerbate examined Express expression Factor growth hair hair follicle haploinsufficiency idea in vivo increased expression leads Lineage maintain maintenance mechanism Melanocyte melanocytes melanogenesis MITF mitigate Mouse models negative regulation observation overexpression pigment portion precursor Premature prevented progenitor raise regulated Regulation Regulatory role Sox10 STEM stem cell stem cells survival sustained target Transcription transcription factor transcription factors [DOI] 10.1371/journal.pgen.1003644 PMC 바로가기 [Article Type] Research Article
Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses통합 "Omics" 접근 방식으로 세균 스트레스 반응의 동적 및 조절 기능 발견Research Article Published on 2013-06-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] (transcriptome adaptation adaptive mechanism adaptive mechanisms addition alternative approach approach assigned Author Bacteria cellular stress responses change choice complex conditions determine different dynamic Effect elevated temperature event events example exhibited expression expression level expression pattern expressome Factor Factors feature found fraction Frequency Gene Genes Genome help in addition to include initiated integration maintain mass spectrometry Microarrays mRNA mRNA level mRNA levels mRNAs Occurrence open reading frames operon organism oxygen phototrophic polar polysome Population post-transcriptional level Protein Proteins proteome provided quantification quorum regulated Regulation Regulatory reported required response RNA-Seq RpoE singlet oxygen Stress stress condition stress conditions stress response stress responses survival transcriptional activation transcriptional level transcriptional regulator transcriptional regulators Transcriptome translation translational was used [DOI] 10.1371/journal.pgen.1003576 PMC 바로가기 [Article Type] Research Article
Differentiated phenotypes of primary murine alveolar epithelial cells and their susceptibility to infection by respiratory virusesArticle Published on 2013-04-292022-11-01 Journal: Virus research [Category] Coronavirus, 신종인플루엔자, [키워드] activating alveolar cell alveolar epithelial cell alveolar epithelial cells ATII Cell cell type cells contribute coronavirus correlated Critical Culture cytokine cytokine expression cytokine response Cytokines determine determined different disease severity epithelial cell exhibited Express expression Factor H1N1 Host IAV identify IL-1β immune responses in vitro model in vivo increased expression Infected Infection influenza A influenza A virus lung Lungs maintain Mouse-adapted SARS-coronavirus mouse-adapted SARS-CoV mRNA murine murine coronavirus murine model Pathogenesis pathology phenotype quantified respiratory viral infection respiratory virus respiratory viruses response robust SARS-CoV severe spread to susceptibility susceptible target type I Type I pneumocyte Type II pneumocyte v2163 viral infection viral infections viral pathogenesis virus viruses while [DOI] 10.1016/j.virusres.2013.04.008 PMC 바로가기 [Article Type] Article
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6 , a Gene Identified through Mining the DPH1 – DPH5 Interaction Network효모에서 디프타마이드 생합성의 아미드화 단계에는 DPH1 - DPH5 상호작용 네트워크 마이닝을 통해 확인된 유전자인 DPH6이 필요합니다Research Article Published on 2013-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate Accuracy adenine adenine nucleotide ADP Affect agent amidase Amino acid approach association ATP Author bind Biosynthesis biosynthetic biosynthetic pathway candidate candidate gene Cell cell growth characterized check Complete completion component components Corynebacterium diphtheriae defined Diphthamide dissociation domain DPH1 Dph5 Dph6 Dph7 eEF2 elongation factor embryogenesis enzyme evade expected failure Final form found generate Genes Genetic genetic interaction genomic growth histidine Identified identify inactivation indicated inhibitor inhibitors initial Interaction involved Like maintain mass spectrometry mice molecular mutant name network nucleotide observation pathogen pathway produced promote Protein protein synthesis Proteins Regulatory required residue response Saccharomyces cerevisiae step target trait translation translational upregulated [DOI] 10.1371/journal.pgen.1003334 PMC 바로가기 [Article Type] Research Article
Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it?Review Published on 2012-05-152022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive Against antigenic arterivirus, porcine reproductive and respiratory syndrome virus CD25 CD28 CD4 CD8 Cell cells chronic inflammation Coronaviral coronavirus cytokine described develop disease Express expression form hallmark homeostasis host response IL-10 Immune homeostasis immune response immune tolerance induction Infection interleukin 2 lactate dehydrogenase lactate dehydrogenase-elevating virus maintain mean mouse hepatitis virus natural Other Pathogenesis PROTECT receptor Regulatory Regulatory T cell reproductive responsible subset syndrome T cell T cell subset T helper TGF-β the disease transcription factor Type viral persistence virus [DOI] 10.3390/v4050833 PMC 바로가기 [Article Type] Review
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus InhibitorsResearch Article Published on 2011-10-272022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation acute respiratory syndrome anti-infective drug Antiviral antiviral target approach Author automated Bacteria binding blocked common cold viruses CoV CoV-229E CoVs cyclophilin cyclosporin A Cytokine dysregulation demonstrated derivative different drug element Epidemics Factor FKBP1A FKBP1B fungi Host host cell host protein Human identification identify Immune cell include induce Infection Infectious Bronchitis Virus inhibited inhibitor Interaction interaction partner interleukin 2 involved led to maintain metabolism modulate Neurological disease non-structural protein nsp1 organism outbreak overlap parasites pathogen Pathogenesis pathway PPIA PPIB PPIG PPIH Protein Replication SARS-CoV severe SARS suggested Systems biology target targets tested Vaccine Viral protein virus virus virus replication Virus-host interaction viruses [DOI] 10.1371/journal.ppat.1002331 PMC 바로가기 [Article Type] Research Article
Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) InfectionResearch Article Published on 2011-07-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activate anti-IFN-γ anti-TNF-α Author blockade cascades CD4 CD8 cells characteristic co-expressed Coagulation Combination Control damaged demonstrated described determined exhibited expression Fgl2 FH fibrinogen Fluorescence fulminant viral hepatitis functional hepatocellular IFN-γ immunopathological immunopathological damage Immunotherapy in vivo Infection inhibitory receptor initiate injection investigated led to limit liver Liver damage Lymph node lymph nodes mAb Macrophage maintain mechanism mice Mortality mortality rate mRNA multiple organs murine hepatitis virus Necrosis NK cell occurred organ Pathogenesis peripheral tolerance produced promote Protein Quantitative reduced related RT-PCR sensitive Signaling significantly higher spleen T cells tissue tissue damage tissue lesion tissue lesions TNF-α Transcription was determined wild type wild-type [DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article
A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal VaccinationResearch Article Published on 2009-01-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Antigen Chinese dissemination doses Efficacy experiments generate genomic location Head-to-head comparison implication Inducing inoculated intramuscular intranasal Level maintain mice mucosal neutralizing antibody novel offer Prevent protective immune response response S gene SARS-CoV SARS-CoV neutralizing antibody spike glycoprotein Superior Tian vaccination Vaccine vaccine candidate vaccinia variant vector Viral transmission Viral vector was used wild-type [DOI] 10.1371/journal.pone.0004180 PMC 바로가기 [Article Type] Research Article
What Internet Services Would Patients Like From Hospitals During an Epidemic? Lessons From the SARS Outbreak in TorontoOriginal Paper Published on 2005-08-032022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome affected age Analysis Care clinics communicable diseases, emerging conducted Descriptive statistics determine emergency situation English Epidemic expressed Health health condition health information Health Service help hospital identify IMPROVE infectious Infectious disease information information services international health Internet Laboratory lesson Like logistic regression model maintain mean Most patient objective organization outbreak pandemic Patient predictor professional promote provided public health Questionnaires Regression responsible restrict Result searched selected service Severe acute respiratory syndrome Toronto unique Web were used World wide web [DOI] 10.2196/jmir.7.4.e46 PMC 바로가기 [Article Type] Original Paper